In vivo monoclonal antibody efficacy against SARS-CoV-2 variant strains.
Angiotensin-Converting Enzyme 2
/ genetics
Animals
Antibodies, Monoclonal
/ immunology
Antibodies, Neutralizing
/ immunology
Antibodies, Viral
/ immunology
COVID-19
/ genetics
Chlorocebus aethiops
Female
Humans
Male
Mesocricetus
/ immunology
Mice
Mice, Transgenic
Neutralization Tests
Post-Exposure Prophylaxis
Pre-Exposure Prophylaxis
SARS-CoV-2
/ drug effects
Serine Endopeptidases
/ genetics
Spike Glycoprotein, Coronavirus
/ genetics
Vero Cells
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
21
04
2021
accepted:
11
06
2021
pubmed:
22
6
2021
medline:
11
8
2021
entrez:
21
6
2021
Statut:
ppublish
Résumé
Rapidly emerging SARS-CoV-2 variants jeopardize antibody-based countermeasures. Although cell culture experiments have demonstrated a loss of potency of several anti-spike neutralizing antibodies against variant strains of SARS-CoV-2
Identifiants
pubmed: 34153975
doi: 10.1038/s41586-021-03720-y
pii: 10.1038/s41586-021-03720-y
pmc: PMC8349859
mid: NIHMS1718835
doi:
Substances chimiques
Antibodies, Monoclonal
0
Antibodies, Neutralizing
0
Antibodies, Viral
0
Spike Glycoprotein, Coronavirus
0
spike protein, SARS-CoV-2
0
ACE2 protein, human
EC 3.4.17.23
Angiotensin-Converting Enzyme 2
EC 3.4.17.23
Serine Endopeptidases
EC 3.4.21.-
HPN protein, human
EC 3.4.21.106
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
103-108Subventions
Organisme : NIAID NIH HHS
ID : 75N93019C00074
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI095202
Pays : United States
Organisme : NIAID NIH HHS
ID : HHSN272201400008C
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI157155
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI141990
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI151810
Pays : United States
Organisme : NIAID NIH HHS
ID : HHSN272201400006C
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007163
Pays : United States
Organisme : NIAID NIH HHS
ID : F30 AI152327
Pays : United States
Organisme : NIAID NIH HHS
ID : 75N93019C00051
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI118938
Pays : United States
Commentaires et corrections
Type : UpdateOf
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Nature Limited.
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