Clarithromycin impairs tissue-resident memory and Th17 responses to macrolide-resistant Streptococcus pneumoniae infections.
Anti-Bacterial Agents
/ pharmacology
Clarithromycin
/ pharmacology
Drug Resistance, Bacterial
Host-Pathogen Interactions
/ immunology
Humans
Immunologic Memory
/ drug effects
Lymphocyte Activation
/ drug effects
MAP Kinase Signaling System
Macrolides
/ pharmacology
Memory T Cells
/ drug effects
Pneumococcal Infections
/ drug therapy
Streptococcus pneumoniae
/ drug effects
Th17 Cells
/ drug effects
Anti-microbial resistance
Clarithromycin
Macrolide antibiotics
Streptococcus pneumoniae
Th17 cells
Tissue-resident memory T cells
Journal
Journal of molecular medicine (Berlin, Germany)
ISSN: 1432-1440
Titre abrégé: J Mol Med (Berl)
Pays: Germany
ID NLM: 9504370
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
05
06
2020
accepted:
12
01
2021
revised:
17
12
2020
pubmed:
18
2
2021
medline:
19
1
2022
entrez:
17
2
2021
Statut:
ppublish
Résumé
The increasing prevalence of antimicrobial resistance in pathogens is a growing public health concern, with the potential to compromise the success of infectious disease treatments in the future. Particularly, the number of infections by macrolide antibiotics-resistant Streptococcus pneumoniae is increasing. We show here that Clarithromycin impairs both the frequencies and number of interleukin (IL)-17 producing T helper (Th) 17 cells within the lungs of mice infected with a macrolide-resistant S. pneumoniae serotype 15A strain. Subsequently, the tissue-resident memory CD4
Identifiants
pubmed: 33595670
doi: 10.1007/s00109-021-02039-5
pii: 10.1007/s00109-021-02039-5
pmc: PMC8164591
doi:
Substances chimiques
Anti-Bacterial Agents
0
Macrolides
0
Clarithromycin
H1250JIK0A
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
817-829Références
Antimicrob Agents Chemother. 1996 Jan;40(1):75-9
pubmed: 8787883
Mucosal Immunol. 2014 May;7(3):501-10
pubmed: 24064670
Eur Respir J. 1994 Jul;7(7):1275-80
pubmed: 7925906
Am J Respir Crit Care Med. 2019 Oct 1;200(7):e45-e67
pubmed: 31573350
J Antimicrob Chemother. 2005 Jan;55(1):10-21
pubmed: 15590715
J Antimicrob Chemother. 2008 Mar;61(3):554-60
pubmed: 18230686
Curr Biol. 2015 Oct 5;25(19):R911-21
pubmed: 26439354
Am J Physiol Lung Cell Mol Physiol. 2006 Jan;290(1):L75-85
pubmed: 16085674
Front Immunol. 2018 Mar 13;9:302
pubmed: 29593707
J Chemother. 1997 Feb;9(1):23-31
pubmed: 9106014
Pharm Res. 2019 Feb 7;36(3):48
pubmed: 30734107
J Antimicrob Chemother. 2007 Jun;59(6):1096-101
pubmed: 17412724
BMC Infect Dis. 2015 May 05;15:207
pubmed: 25940580
Respir Res. 2010 Jun 30;11:90
pubmed: 20591166
Eur Respir J. 2006 May;27(5):1020-5
pubmed: 16455827
Cell Rep. 2012 Apr 19;1(4):360-73
pubmed: 22832227
J Immunol. 2017 Jul 1;199(1):233-243
pubmed: 28533445
Infect Immun. 1997 Jan;65(1):257-60
pubmed: 8975920
EMBO Rep. 2018 Aug;19(8):
pubmed: 29895711
J Antimicrob Chemother. 2011 Oct;66(10):2323-9
pubmed: 21791441
J Immunol. 2011 Dec 1;187(11):5510-4
pubmed: 22058417
J Immunol. 2020 May 1;204(9):2429-2438
pubmed: 32213566
J Biol Chem. 2010 Jul 16;285(29):22328-37
pubmed: 20463015
Cell Death Dis. 2018 Jan 18;9(2):29
pubmed: 29348439
Immunity. 2021 Jan 12;54(1):68-83.e6
pubmed: 33238133
Biochim Biophys Acta. 1973 Dec 7;331(2):264-75
pubmed: 4272715
Lancet Infect Dis. 2020 Jan;20(1):60-79
pubmed: 31678026
Sci Rep. 2014 Dec 11;4:7438
pubmed: 25500904
Front Cell Infect Microbiol. 2016 Sep 21;6:98
pubmed: 27709102
Thorax. 2006 Oct;61(10):895-902
pubmed: 16809416
J Am Board Fam Med. 2012 Jul-Aug;25(4):442-59
pubmed: 22773713
Lancet. 2009 Sep 12;374(9693):893-902
pubmed: 19748398
Mol Cell Biol. 2004 Apr;24(8):3112-24
pubmed: 15060135
Clin Exp Immunol. 2011 Dec;166(3):385-92
pubmed: 22059997
Front Immunol. 2018 Jul 30;9:1764
pubmed: 30105030
Mucosal Immunol. 2018 Jan;11(1):220-235
pubmed: 28513594
PLoS Pathog. 2008 Sep 19;4(9):e1000159
pubmed: 18802458
PLoS One. 2010 Nov 10;5(11):e15425
pubmed: 21085672
Respirology. 2012 May;17(4):727-34
pubmed: 22404374
Mediators Inflamm. 2012;2012:584262
pubmed: 22778497
Lancet. 2012 Aug 18;380(9842):660-7
pubmed: 22901887
Int J Antimicrob Agents. 2001 Nov;18(5):419-25
pubmed: 11711255
Euro Surveill. 2016 Dec 15;21(50):
pubmed: 28006650
Cell Mol Life Sci. 2016 Dec;73(23):4397-4413
pubmed: 27342992
Am J Respir Crit Care Med. 1998 Jun;157(6 Pt 1):1829-32
pubmed: 9620913
Mucosal Immunol. 2016 Sep;9(5):1288-302
pubmed: 26627460
Mucosal Immunol. 2015 May;8(3):627-39
pubmed: 25354319
Curr Opin Immunol. 2019 Aug;59:101-108
pubmed: 31265968