Exercise triggers CAPN1-mediated AIF truncation, inducing myocyte cell death in arrhythmogenic cardiomyopathy.

Animals Apoptosis Inducing Factor / metabolism Calpain / metabolism Cardiomyopathies / metabolism Cell Death Mice Mitochondria / metabolism Myocytes, Cardiac / metabolism Physical Conditioning, Animal

Journal

Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086

Informations de publication

Date de publication:
17 02 2021
Historique:
received: 02 10 2020
accepted: 27 01 2021
entrez: 18 2 2021
pubmed: 19 2 2021
medline: 13 7 2021
Statut: ppublish

Résumé

Myocyte death occurs in many inherited and acquired cardiomyopathies, including arrhythmogenic cardiomyopathy (ACM), a genetic heart disease plagued by the prevalence of sudden cardiac death. Individuals with ACM and harboring pathogenic desmosomal variants, such as desmoglein-2 (

Identifiants

DOI: 10.1126/scitranslmed.abf0891 PMID: 33597260 PMC: PMC8936193
pubmed: 33597260
pii: 13/581/eabf0891
doi: 10.1126/scitranslmed.abf0891
pmc: PMC8936193
mid: NIHMS1781583
pii:
doi:

Substances chimiques

Apoptosis Inducing Factor 0
Calpain EC 3.4.22.-
Capn1 protein, mouse EC 3.4.22.52

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL134821
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL138475
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG058527
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD086026
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL137259
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL136918
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL063030
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL156947
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Références

Cell. 2004 Jun 11;117(6):773-86
pubmed: 15186778
Biochem J. 2018 Jul 31;475(14):2377-2393
pubmed: 29891613
PLoS One. 2008 Sep 15;3(9):e3208
pubmed: 18791645
EMBO J. 2002 Apr 2;21(7):1695-703
pubmed: 11927553
J Am Coll Cardiol. 2013 Oct 1;62(14):1290-1297
pubmed: 23871885
J Biol Chem. 2005 Jun 10;280(23):22070-80
pubmed: 15817486
Circ Res. 2008 Mar 28;102(6):720-8
pubmed: 18258859
Mol Cell Biol. 2005 Dec;25(23):10261-72
pubmed: 16287843
J Clin Invest. 2003 Nov;112(9):1395-406
pubmed: 14597765
J Clin Invest. 2006 Jul;116(7):2012-21
pubmed: 16823493
J Physiol. 2014 Nov 1;592(21):4613-26
pubmed: 25260630
Mol Med. 2008 Jul-Aug;14(7-8):476-84
pubmed: 18431461
J Am Soc Echocardiogr. 2005 Sep;18(9):982-90
pubmed: 16153531
J Biol Chem. 2014 Dec 5;289(49):33984-98
pubmed: 25336645
Cardiovasc Res. 2006 May 1;70(2):191-9
pubmed: 16497286
J Biol Chem. 1998 May 22;273(21):13331-8
pubmed: 9582380
Biochem Biophys Res Commun. 2011 Dec 2;415(4):533-8
pubmed: 22057010
Circ Res. 2014 Jan 31;114(3):454-68
pubmed: 24276085
Nature. 2005 Mar 31;434(7033):652-8
pubmed: 15800626
Circulation. 1996 Mar 1;93(5):841-2
pubmed: 8598070
Eur J Pharmacol. 2008 Jul 7;588(2-3):239-43
pubmed: 18502415
Elife. 2014 Apr 24;3:e02164
pubmed: 24843018
Oncogene. 2004 Feb 26;23(8):1514-21
pubmed: 14716299
Am J Physiol Heart Circ Physiol. 2009 Nov;297(5):H1744-51
pubmed: 19734364
Hum Gene Ther. 2001 Nov 20;12(17):2051-63
pubmed: 11747596
Physiol Rev. 2003 Jul;83(3):731-801
pubmed: 12843408
Physiol Rev. 2008 Oct;88(4):1243-76
pubmed: 18923182
Antioxid Redox Signal. 2011 Jun 15;14(12):2545-79
pubmed: 20868295
J Neurochem. 2002 Jul;82(1):181-91
pubmed: 12091479
Nat Struct Biol. 2002 Apr;9(4):239-41
pubmed: 11914728
Cell Death Differ. 2005 Nov;12(11):1445-8
pubmed: 15933737
Biochimie. 2002 Feb-Mar;84(2-3):215-22
pubmed: 12022952
J Biol Chem. 2005 Feb 25;280(8):6447-54
pubmed: 15590628
JCI Insight. 2016 Apr 21;1(5):
pubmed: 27170944
Bioessays. 1997 Nov;19(11):1011-8
pubmed: 9394623
J Mol Cell Cardiol. 2010 Aug;49(2):271-9
pubmed: 20211186
Front Neurosci. 2018 Feb 06;12:44
pubmed: 29467609
Mol Med Rep. 2013 Sep;8(3):780-6
pubmed: 23877755
Nature. 2013 Feb 7;494(7435):105-10
pubmed: 23354045
Nat Cell Biol. 2001 Sep;3(9):839-43
pubmed: 11533664
Circulation. 2019 Oct 29;140(18):1491-1505
pubmed: 31533459
J Mol Cell Cardiol. 1998 Mar;30(3):495-507
pubmed: 9515027
Oncogene. 2007 Apr 26;26(19):2717-26
pubmed: 17130844
J Biol Chem. 2011 Sep 23;286(38):33669-77
pubmed: 21832082
Annu Rev Pathol. 2011;6:299-321
pubmed: 21073337
J Physiol. 2013 Jul 15;591(14):3471-86
pubmed: 23613536
Circ Res. 2011 Apr 15;108(8):1017-36
pubmed: 21493924
Arch Biochem Biophys. 2007 Sep 1;465(1):148-56
pubmed: 17570336
Circulation. 2009 Mar 3;119(8):1085-92
pubmed: 19221222
J Clin Invest. 2007 Sep;117(9):2431-44
pubmed: 17694179
Nat Struct Biol. 2002 Sep;9(9):680-4
pubmed: 12198487
Biochem Biophys Res Commun. 1996 Dec 4;229(1):193-7
pubmed: 8954105
Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18314-9
pubmed: 17116881
J Neurochem. 2009 Jul;110(2):687-96
pubmed: 19457082
J Am Heart Assoc. 2018 Jun 16;7(12):
pubmed: 29909402
Europace. 2010 Jun;12(6):861-8
pubmed: 20400443
Br J Pharmacol. 2006 Dec;149(7):829-37
pubmed: 17031386
Circulation. 2009 Jan 27;119(3):480-6
pubmed: 19171871
Neth Heart J. 2017 Mar;25(3):157-169
pubmed: 28102477
N Engl J Med. 1996 Oct 17;335(16):1190-6
pubmed: 8815941
Cell Rep. 2017 Jan 10;18(2):571-582
pubmed: 28076798
Cell Death Dis. 2014 Jan 16;5:e993
pubmed: 24434516
Am J Physiol Endocrinol Metab. 2006 Jun;290(6):E1172-9
pubmed: 16403773
Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):2979-84
pubmed: 9501201
EBioMedicine. 2018 Apr;30:29-37
pubmed: 29605508
Free Radic Biol Med. 2015 Oct;87:326-35
pubmed: 26159509
J Exp Med. 2000 Oct 2;192(7):1001-14
pubmed: 11015441
Oncogene. 2003 Oct 2;22(43):6669-78
pubmed: 14555980
FASEB J. 2000 Apr;14(5):729-39
pubmed: 10744629
J Physiol. 1995 Jul 1;486 ( Pt 1):1-13
pubmed: 7562625
J Neurochem. 1990 Aug;55(2):698-707
pubmed: 2164576
Nature. 1999 Feb 4;397(6718):441-6
pubmed: 9989411
Am J Hum Genet. 2010 Apr 9;86(4):639-49
pubmed: 20362274
Nat Clin Pract Cardiovasc Med. 2008 May;5(5):258-67
pubmed: 18382419
Biotech Histochem. 2008 Jun;83(3-4):153-9
pubmed: 18846451
Annu Rev Pathol. 2017 Jan 24;12:103-130
pubmed: 27959630
J Biol Chem. 1999 May 14;274(20):14046-52
pubmed: 10318818
Mol Metab. 2020 Oct;40:101027
pubmed: 32480041
Eur Heart J. 2011 Aug;32(15):1846-53
pubmed: 21398641
Am J Med Sci. 2000 Nov;320(5):310-9
pubmed: 11093683
Cardiovasc Res. 2012 Oct 1;96(1):23-31
pubmed: 22787134
J Exp Med. 2007 Aug 6;204(8):1741-8
pubmed: 17635954
Oncotarget. 2016 Nov 22;7(47):76479-76495
pubmed: 27835610
FEBS J. 2006 May;273(10):2077-99
pubmed: 16649987
Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H314-26
pubmed: 18487434
J Clin Invest. 2003 May;111(10):1497-504
pubmed: 12750399
Biochim Biophys Acta. 2012 Jan;1824(1):224-36
pubmed: 21864727
Arch Biochem Biophys. 2001 Nov 1;395(1):1-13
pubmed: 11673859
Circ Res. 2007 Apr 13;100(7):1071-8
pubmed: 17332428
J Am Heart Assoc. 2014 Dec;3(6):e001471
pubmed: 25516436
Cardiovasc Pathol. 2010 May-Jun;19(3):166-70
pubmed: 20051321
Circ Cardiovasc Genet. 2015 Jun;8(3):437-46
pubmed: 25820315
Neuropharmacology. 2020 Jul;171:108088
pubmed: 32277944
Circulation. 2006 Mar 7;113(9):1171-9
pubmed: 16505173
J Biol Chem. 2007 Aug 3;282(31):22406-13
pubmed: 17569662
Circulation. 2006 Apr 11;113(14):1779-86
pubmed: 16585391
Diabetes. 2016 Jan;65(1):255-68
pubmed: 26470784
Front Physiol. 2018 May 23;9:571
pubmed: 29875683
Cell Metab. 2016 Feb 9;23(2):254-63
pubmed: 26777689
Mol Med. 2003 May-Aug;9(5-8):143-53
pubmed: 14571322
Free Radic Biol Med. 2010 Mar 15;48(6):791-7
pubmed: 20043986
J Clin Invest. 2004 Jun;113(11):1535-49
pubmed: 15173880
Circulation. 2014 Mar 11;129(10):1092-103
pubmed: 24352520
Mitochondrion. 2015 Sep;24:64-76
pubmed: 26190566
J Atheroscler Thromb. 2013;20(3):228-37
pubmed: 23171729

Auteurs

Stephen P Chelko (SP)

Department of Biomedical Sciences, Florida State University, Tallahassee, FL 32306, USA. stephen.chelko@med.fsu.edu npaoloc1@jhmi.edu.
Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
ORCID: 0000-0003-1675-5945

Gizem Keceli (G)

Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
ORCID: 0000-0002-9562-7994

Andrea Carpi (A)

Department of Biomedical Sciences, University of Padova, Padova 35122, Italy.

Nunzianna Doti (N)

Institute of Biostructures and Bioimaging, CNR, Naples 80134, Italy.
ORCID: 0000-0003-2952-6658

Jacopo Agrimi (J)

Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.

Angeliki Asimaki (A)

Molecular and Clinical Sciences Research Institute, St. George's, University of London, London WC1E 6BS, UK.
ORCID: 0000-0001-9886-6870

Carlos Bueno Beti (CB)

Molecular and Clinical Sciences Research Institute, St. George's, University of London, London WC1E 6BS, UK.

Matthew Miyamoto (M)

Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
ORCID: 0000-0002-2140-6769

Nuria Amat-Codina (N)

Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.

Djahida Bedja (D)

Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Australian School of Advanced Medicine, Macquarie University, Sydney, NSW 2109, Australia.
ORCID: 0000-0003-1716-6835

An-Chi Wei (AC)

Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
ORCID: 0000-0001-7927-1636

Brittney Murray (B)

Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
ORCID: 0000-0001-7870-8584

Crystal Tichnell (C)

Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.

Chulan Kwon (C)

Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.

Hugh Calkins (H)

Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.

Cynthia A James (CA)

Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
ORCID: 0000-0001-8040-4600

Brian O'Rourke (B)

Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
ORCID: 0000-0002-5548-4853

Marc K Halushka (MK)

Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
ORCID: 0000-0002-7112-7389

Edon Melloni (E)

Department of Medicine, University of Genova, Genova 16126, Italy.

Jeffrey E Saffitz (JE)

Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 20115, USA.
ORCID: 0000-0001-8568-9457

Daniel P Judge (DP)

Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Medical University of South Carolina, Charleston, SC 29425, USA.
ORCID: 0000-0002-3407-0248

Menotti Ruvo (M)

Institute of Biostructures and Bioimaging, CNR, Naples 80134, Italy.
ORCID: 0000-0001-5997-756X

Richard N Kitsis (RN)

Departments of Medicine and Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
ORCID: 0000-0003-1395-9694

Peter Andersen (P)

Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
ORCID: 0000-0003-3971-0467

Fabio Di Lisa (F)

Department of Biomedical Sciences, University of Padova, Padova 35122, Italy.

Nazareno Paolocci (N)

Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA. stephen.chelko@med.fsu.edu npaoloc1@jhmi.edu.
Department of Biomedical Sciences, University of Padova, Padova 35122, Italy.
ORCID: 0000-0001-7011-997X

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Exercise triggers CAPN1-mediated AIF...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › Protéines liant le poly-adp-ribose › Facteur inducteur d'apoptose › Exercise triggers CAPN1-mediated AIF...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Endopeptidases › Cysteine endopeptidases › Calpain › Exercise triggers CAPN1-mediated AIF...
questionsmedicales.fr › Maladies cardiovasculaires › Cardiopathies › Cardiomyopathies › Exercise triggers CAPN1-mediated AIF...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Exercise triggers CAPN1-mediated AIF...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Exercise triggers CAPN1-mediated AIF...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Exercise triggers CAPN1-mediated AIF...
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes cardiaques › Exercise triggers CAPN1-mediated AIF...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Mouvement › Activité motrice › Conditionnement physique d'animal › Exercise triggers CAPN1-mediated AIF...