Loop extrusion as a mechanism for formation of DNA damage repair foci.
Cell Cycle Proteins
/ metabolism
Cell Line
Chromosomal Proteins, Non-Histone
/ metabolism
DNA
/ chemistry
DNA Breaks, Double-Stranded
DNA Repair
Genome
/ genetics
Histones
/ metabolism
Humans
Nucleic Acid Conformation
Nucleosomes
/ chemistry
Phosphorylation
Saccharomyces cerevisiae
/ cytology
Saccharomyces cerevisiae Proteins
/ metabolism
Tumor Suppressor p53-Binding Protein 1
/ metabolism
Cohesins
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
07
02
2020
accepted:
06
01
2021
pubmed:
19
2
2021
medline:
9
11
2021
entrez:
18
2
2021
Statut:
ppublish
Résumé
The repair of DNA double-strand breaks (DSBs) is essential for safeguarding genome integrity. When a DSB forms, the PI3K-related ATM kinase rapidly triggers the establishment of megabase-sized, chromatin domains decorated with phosphorylated histone H2AX (γH2AX), which act as seeds for the formation of DNA-damage response foci
Identifiants
pubmed: 33597753
doi: 10.1038/s41586-021-03193-z
pii: 10.1038/s41586-021-03193-z
pmc: PMC7116834
mid: EMS114641
doi:
Substances chimiques
Cell Cycle Proteins
0
Chromosomal Proteins, Non-Histone
0
H2AX protein, human
0
Histones
0
Nucleosomes
0
Saccharomyces cerevisiae Proteins
0
Tumor Suppressor p53-Binding Protein 1
0
gammaH2AX protein, S cerevisiae
0
DNA
9007-49-2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
660-665Subventions
Organisme : European Research Council
ID : 647344
Pays : International
Organisme : NIGMS NIH HHS
ID : R35 GM127029
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007122
Pays : United States
Commentaires et corrections
Type : CommentIn
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