Kallikrein-1 Blockade Inhibits Aortic Expansion in a Mouse Model and Reduces Prostaglandin E2 Secretion From Human Aortic Aneurysm Explants.
aneurysm
cyclooxygenase‐2
kallikrein‐1
prostaglandin E2
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
pubmed:
19
2
2021
medline:
15
10
2021
entrez:
18
2
2021
Statut:
ppublish
Résumé
Background Abdominal aortic aneurysm (AAA) is an important cause of mortality in older adults. The kinin B2 receptor agonist, bradykinin, has been implicated in AAA pathogenesis through promoting inflammation. Bradykinin is generated from high- and low-molecular-weight kininogen by the serine protease kallikrein-1. The aims of this study were first to examine the effect of neutralizing kallikrein-1 on AAA development in a mouse model and second to test how blocking kallikrein-1 affected cyclooxygenase-2 and prostaglandin E
Identifiants
pubmed: 33599139
doi: 10.1161/JAHA.120.019372
pmc: PMC8174241
doi:
Substances chimiques
Tissue Kallikreins
EC 3.4.21.35
Dinoprostone
K7Q1JQR04M
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e019372Références
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