Non-canonical roles of canonical telomere binding proteins in cancers.
Cell Cycle Proteins
/ genetics
Dyskeratosis Congenita
/ genetics
Humans
Neoplasms
/ metabolism
Nuclear Proteins
/ genetics
Promoter Regions, Genetic
Ribonucleoproteins, Small Nucleolar
/ genetics
Telomerase
/ genetics
Telomere
/ metabolism
Telomere-Binding Proteins
/ chemistry
rap1 GTP-Binding Proteins
/ genetics
Cancer
Shelterin
TERT
Telomerase
Telomere
Journal
Cellular and molecular life sciences : CMLS
ISSN: 1420-9071
Titre abrégé: Cell Mol Life Sci
Pays: Switzerland
ID NLM: 9705402
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
received:
05
08
2020
accepted:
29
01
2021
revised:
28
12
2020
pubmed:
19
2
2021
medline:
10
6
2021
entrez:
18
2
2021
Statut:
ppublish
Résumé
Reactivation of telomerase is a major hallmark observed in 90% of all cancers. Yet paradoxically, enhanced telomerase activity does not correlate with telomere length and cancers often possess short telomeres; suggestive of supplementary non-canonical roles that telomerase might play in the development of cancer. Moreover, studies have shown that aberrant expression of shelterin proteins coupled with their release from shortening telomeres can further promote cancer by mechanisms independent of their telomeric role. While targeting telomerase activity appears to be an attractive therapeutic option, this approach has failed in clinical trials due to undesirable cytotoxic effects on stem cells. To circumvent this concern, an alternative strategy could be to target the molecules involved in the non-canonical functions of telomeric proteins. In this review, we will focus on emerging evidence that has demonstrated the non-canonical roles of telomeric proteins and their impact on tumorigenesis. Furthermore, we aim to address current knowledge gaps in telomeric protein functions and propose future research approaches that can be undertaken to achieve this.
Identifiants
pubmed: 33599797
doi: 10.1007/s00018-021-03783-0
pii: 10.1007/s00018-021-03783-0
pmc: PMC8164586
doi:
Substances chimiques
Cell Cycle Proteins
0
DKC1 protein, human
0
GAR1 protein, human
0
Nuclear Proteins
0
Ribonucleoproteins, Small Nucleolar
0
Telomere-Binding Proteins
0
Telomerase
EC 2.7.7.49
rap1 GTP-Binding Proteins
EC 3.6.5.2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
4235-4257Subventions
Organisme : National Medical Research Council (SG)
ID : OFYIRG/18MAY-0008
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