The impact of DAA-mediated HCV eradication on CD4


Journal

Journal of viral hepatitis
ISSN: 1365-2893
Titre abrégé: J Viral Hepat
Pays: England
ID NLM: 9435672

Informations de publication

Date de publication:
05 2021
Historique:
received: 27 12 2020
accepted: 31 01 2021
pubmed: 19 2 2021
medline: 2 10 2021
entrez: 18 2 2021
Statut: ppublish

Résumé

HCV infection has been hypothesized as a contributor of poor CD4

Identifiants

pubmed: 33600068
doi: 10.1111/jvh.13488
doi:

Substances chimiques

Antiviral Agents 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

779-786

Investigateurs

M Andreoni (M)
A Castagna (A)
F Castelli (F)
R Cauda (R)
G Di Perri (G)
M Galli (M)
R Iardino (R)
G Ippolito (G)
A Lazzarin (A)
G C Marchetti (GC)
G Rezza (G)
F von Shloesser (F)
P Viale (P)
A Castagna (A)
E Girardi (E)
S Lo Caputo (S)
F Maggiolo (F)
C F Perno (CF)
F Bai (F)
S Bonora (S)
M Borderi (M)
A Calcagno (A)
M R Capobianchi (MR)
A Castagna (A)
S Cicalini (S)
A Cingolani (A)
P Cinque (P)
A Di Biagio (A)
R Gagliardini (R)
E Girardi (E)
N Gianotti (N)
G Guaraldi (G)
M Lichtner (M)
A Lai (A)
G Madeddu (G)
F Maggiolo (F)
G Marchetti (G)
E Merlini (E)
S Nozza (S)
C F Perno (CF)
S Piconi (S)
C Pinnetti (C)
R Rossotti (R)
S Rusconi (S)
M M Santoro (MM)
L Sarmati (L)
V Spagnuolo (V)
V Svicher (V)
I Fanti (I)
L Galli (L)
A Rodano' (A)
M Macchia (M)
A Tavelli (A)
A Bove (A)
A Camposeragna (A)
M Errico (M)
M Manfredini (M)
A Perziano (A)
V Calvino (V)
F Carletti (F)
S Carrara (S)
A Di Caro (A)
S Graziano (S)
F Petroni (F)
G Prota (G)
S Truffa (S)
A Giacometti (A)
A Costantini (A)
V Barocci (V)
G Angarano (G)
L Monno (L)
E Milano (E)
F Maggiolo (F)
C Suardi (C)
P Viale (P)
V Donati (V)
G Verucchi (G)
F Castelnuovo (F)
C Minardi (C)
B Menzaghi (B)
C Abeli (C)
L Chessa (L)
F Pes (F)
B Cacopardo (B)
B Celesia (B)
J Vecchiet (J)
K Falasca (K)
A Pan (A)
S Lorenzotti (S)
L Sighinolfi (L)
D Segala (D)
P Blanc (P)
F Vichi (F)
G Cassola (G)
M Bassetti (M)
A Alessandrini (A)
N Bobbio (N)
G Mazzarello (G)
M Lichtner (M)
L Fondaco (L)
P Bonfanti (P)
C Molteni (C)
A Chiodera (A)
P Milini (P)
G Nunnari (G)
G Pellicanò (G)
M Galli (M)
A Lazzarin (A)
G Rizzardini (G)
A Castagna (A)
E S Cannizzo (ES)
M C Moioli (MC)
R Piolini (R)
D Bernacchia (D)
A Poli (A)
C Tincati (C)
C Puzzolante (C)
C Migliorino (C)
V Sangiovanni (V)
G Borgia (G)
V Esposito (V)
G Di Flumeri (G)
I Gentile (I)
V Rizzo (V)
A M Cattelan (AM)
S Marinello (S)
A Cascio (A)
M Trizzino (M)
D Francisci (D)
E Schiaroli (E)
G Parruti (G)
F Sozio (F)
C Lazzaretti (C)
R Corsini (R)
M Andreoni (M)
R Cauda (R)
A Cristaudo (A)
V Vullo (V)
R Acinapura (R)
S Lamonica (S)
M Capozzi (M)
A Mondi (A)
A Cingolani (A)
M Rivano Capparuccia (M)
G Iaiani (G)
A Latini (A)
G Onnelli (G)
M M Plazzi (MM)
G De Girolamo (G)
A Vergori (A)
M Cecchetto (M)
F Viviani (F)
G Madeddu (G)
A De Vito (A)
B Rossetti (B)
A Franco (A)
R Fontana Del Vecchio (R)
C Di Giuli (C)
P Caramello (P)
G Di Perri (G)
S Bonora (S)
G C Orofino (GC)
M Sciandra (M)
A Londero (A)
V Manfrin (V)
G Battagin (G)
G Starnini (G)
A Ialungo (A)

Informations de copyright

© 2021 John Wiley & Sons Ltd.

Références

Boulougoura A, Sereti I. HIV infection and immune activation: the role of coinfections. Curr Opin HIV AIDS. 2016;11(2):191-200.
Hodowanec AC, Lee RD, Brady KE, et al. A matched cross-sectional study of the association between circulating tissue factor activity, immune activation and advanced liver fibrosis in hepatitis C infection. BMC Infect Dis. 2015;15:190.
Márquez M, Romero-Cores P, Montes-Oca M, et al. Immune activation response in chronic HIV-infected patients: influence of Hepatitis C virus coinfection. PLoS One. 2015;10(3):e0119568.
Gonzalez VD, Falconer K, Blom KG, et al. High levels of chronic immune activation in the T-cell compartments of patients coinfected with hepatitis C virus and human immunodeficiency virus type 1 and on highly active antiretroviral therapy are reverted by alpha interferon and ribavirin treatment. J Virol. 2009;83(21):11407-11411.
Sajadi MM, Pulijala R, Redfield RR, Talwani R. Chronic immune activation and decreased CD4 cell counts associated with hepatitis C infection in HIV-1 natural viral suppressors. AIDS. 2012;26(15):1879-1884.
Hodowanec AC, Brady KE, Gao W, et al. Characterization of CD4+ T-cell immune activation and interleukin 10 levels among HIV, hepatitis C virus, and HIV/HCV-coinfected patients. J Acquir Immune Defic Syndr. 2013;64(3):232-240.
Paiardini M, Müller-Trutwin M. HIV-associated chronic immune activation. Immunol Rev. 2013;254(1):78-101.
Gazzola L, Tincati C, Bellistrì GM, d’Arminio MA, Marchetti G. The absence of CD4+ T cell count recovery despite receipt of virologically suppressive highly active antiretroviral therapy: clinical risk, immunological gaps, and therapeutic options. Clin Infect Dis. 2009;48(3):328-337.
Kushner LE, Wendelboe AM, Lazzeroni LC, et al. Immune biomarker differences and changes comparing HCV mono-infected, HIV/HCV co-infected, and HCV spontaneously cleared patients. PLoS One. 2013;8(4):e60387.
Chew KW, Hua L, Bhattacharya D, et al. The effect of hepatitis C virologic clearance on cardiovascular disease biomarkers in human immunodeficiency virus/hepatitis C virus coinfection. Open Forum Infect Dis. 2014;1(3):ofu104.
López-Cortés LF, Trujillo-Rodríguez M, Báez-Palomo A, et al. Eradication of Hepatitis C Virus (HCV) Reduces Immune Activation, Microbial Translocation, and the HIV DNA Level in HIV/HCV-Coinfected Patients. J Infect Dis. 2018;218(4):624-632.
Emmanuel B, El-Kamary SS, Magder LS, et al. Immunological recovery in T-cell activation after sustained virologic response among HIV positive and HIV negative chronic Hepatitis C patients. Hepatol Int. 2019;13(3):270-276.
Shmagel KV, Korolevskaya LB, Saidakova EV, et al. HCV coinfection of the HIV-infected patients with discordant CD4+ T-cell response to antiretroviral therapy leads to intense systemic inflammation. Dokl Biol Sci. 2017;477(1):244-247.
Maria AD, Cossarizza A. CD4saurus Rex & HIVelociraptor vs. development of clinically useful immunological markers: a Jurassic tale of frozen evolution. J Transl Med. 2011;9:93.
Meissner EG, Kohli A, Higgins J, et al. Rapid changes in peripheral lymphocyte concentrations during interferon-free treatment of chronic hepatitis C virus infection. Hepatol Commun. 2017;1(7):586-594.
Orr C, Aartun J, Masur H, Kottilil S, Meissner EG. Characterization of changes in intrahepatic immune cell populations during HCV treatment with sofosbuvir and ribavirin. J Viral Hepat. 2019;26(3):323-328.
Tam RC, Pai B, Bard J, et al. Ribavirin polarizes human T cell responses towards a Type 1 cytokine profile. J Hepatol. 1999;30(3):376-382.
Powers CN, Peavy DL, Knight V. Selective inhibition of functional lymphocyte subpopulations by ribavirin. Antimicrob Agents Chemother. 1982;22(1):108-114.
EASL Recommendations on Treatment of Hepatitis C 2016. J Hepatol. 2017;66(1):153-194.
Martín J, Navas S, Quiroga JA, Pardo M, Carreño V. Effects of the ribavirin-interferon alpha combination on cultured peripheral blood mononuclear cells from chronic hepatitis C patients. Cytokine. 1998;10(8):635-644.

Auteurs

Alessandra Bandera (A)

Infectious Disease Unit, Department of Internal Medicine, Fondazione IRCCS Ca, Granda, Ospedale Maggiore Policlinico, Milan, Italy.
Department of Pathophysiology and Transplantation, University of Milano, Milan, Italy.

Patrizia Lorenzini (P)

HIV/AIDS Clinical Department, National Institute for Infectious Diseases "Lazzaro Spallanzani", Rome, Italy.

Lucia Taramasso (L)

Infectious Disease Unit, Department of Internal Medicine, Fondazione IRCCS Ca, Granda, Ospedale Maggiore Policlinico, Milan, Italy.
Infectious Diseases Clinic, IRCCS Policlinico San Martino Hospital, Genoa, Italy.

Alessandro Cozzi-Lepri (A)

Centre for Clinical Research, Epidemiology, Modelling and Evaluation (CREME), Institute for Global Health UCL, London, UK.

Giuseppe Lapadula (G)

Division of Infectious Diseases, Department of Internal Medicine, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy.

Cristina Mussini (C)

Infectious Disease Clinic, University of Modena and Reggio Emilia, Modena, Italy.

Annalisa Saracino (A)

Institute of Infectious Disease, University of Bari, Bari, Italy.

Francesca Ceccherini-Silberstein (F)

Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.

Massimo Puoti (M)

Department of Infectious Diseases, Grande Ospedale Metropolitano Niguarda, Milan, Italy.

Eugenia Quiros-Roldan (E)

Infectious Diseases, Spedali Civili Hospital, Brescia, Italy.

Francesca Montagnani (F)

Hospital Department of Specialized and Internal Medicine, University Division of Infectious Diseases, Siena, Italy.

Andrea Antinori (A)

HIV/AIDS Clinical Department, National Institute for Infectious Diseases "Lazzaro Spallanzani", Rome, Italy.

A d'Arminio Monforte (A)

Department of Health Sciences, Clinic of Infectious and Tropical Diseases, ASST Santi Paolo e Carlo, University of Milan, Milan, Italy.

Andrea Gori (A)

Infectious Disease Unit, Department of Internal Medicine, Fondazione IRCCS Ca, Granda, Ospedale Maggiore Policlinico, Milan, Italy.
Department of Pathophysiology and Transplantation, University of Milano, Milan, Italy.

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