Smell and taste disorders in COVID-19: From pathogenesis to clinical features and outcomes.
Ageusia
Anosmia
COVID-19
Journal
Neuroscience letters
ISSN: 1872-7972
Titre abrégé: Neurosci Lett
Pays: Ireland
ID NLM: 7600130
Informations de publication
Date de publication:
23 03 2021
23 03 2021
Historique:
received:
15
10
2020
revised:
10
01
2021
accepted:
18
01
2021
pubmed:
19
2
2021
medline:
17
3
2021
entrez:
18
2
2021
Statut:
ppublish
Résumé
Patients with COVID-19 often complain of smell and taste disorders (STD). STD emerge early in the course of the disease, seem to be more common in SARS-CoV-2 infection than in other upper respiratory tract infections, and could in some cases persist for long after resolution of respiratory symptoms. Current evidence suggests that STD probably result from a loss of function of olfactory sensory neurons and taste buds, mainly caused by infection, inflammation, and subsequent dysfunction of supporting non-neuronal cells in the mucosa. However, the possible occurrence of other mechanisms leading to chemosensory dysfunction has also been hypothesized, and contrasting data have been reported regarding the direct infection of sensory neurons by SARS-CoV-2. In this mini-review, we summarize the currently available literature on pathogenesis, clinical manifestations, diagnosis, and outcomes of STD in COVID-19 and discuss possible future directions of research on this topic.
Identifiants
pubmed: 33600902
pii: S0304-3940(21)00072-0
doi: 10.1016/j.neulet.2021.135694
pmc: PMC7883672
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
135694Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.
Références
Clin Infect Dis. 2020 Jul 28;71(15):889-890
pubmed: 32215618
Eur J Neurol. 2020 Nov;27(11):2318-2321
pubmed: 32677329
JAMA Otolaryngol Head Neck Surg. 2021 Mar 1;147(3):271-279
pubmed: 33410887
Cell Host Microbe. 2020 Jul 8;28(1):124-133.e4
pubmed: 32485164
ACS Pharmacol Transl Sci. 2020 Jul 23;3(4):749-758
pubmed: 32821883
Clin Infect Dis. 2021 Jul 15;73(2):e503-e512
pubmed: 32667973
Eur Arch Otorhinolaryngol. 2020 Aug;277(8):2389-2390
pubmed: 32328771
N Engl J Med. 2021 Feb 4;384(5):481-483
pubmed: 33378608
Nat Rev Neurosci. 2006 Nov;7(11):890-901
pubmed: 17053812
Arch Otolaryngol Head Neck Surg. 2007 Apr;133(4):331-6
pubmed: 17438246
Chem Senses. 2014 Mar;39(3):185-94
pubmed: 24429163
Lancet Infect Dis. 2020 Dec;20(12):1401-1408
pubmed: 32758438
Curr Allergy Asthma Rep. 2004 May;4(3):230-6
pubmed: 15056406
Head Neck. 2020 Jun;42(6):1252-1258
pubmed: 32342566
N Engl J Med. 2020 Feb 20;382(8):727-733
pubmed: 31978945
J Allergy Clin Immunol. 2021 Jan;147(1):107-111
pubmed: 32920092
J Otolaryngol Head Neck Surg. 2020 May 4;49(1):26
pubmed: 32366299
JAMA Otolaryngol Head Neck Surg. 2020 Aug 1;146(8):729-732
pubmed: 32614442
Eur Respir J. 2020 Sep 24;56(3):
pubmed: 32817004
JAMA Neurol. 2020 Aug 1;77(8):1028-1029
pubmed: 32469400
J Virol. 2008 Aug;82(15):7264-75
pubmed: 18495771
Chem Senses. 2006 Jul;31(6):595-8
pubmed: 16754696
Neurology. 2020 Dec 8;95(23):e3145-e3152
pubmed: 32917809
Int Forum Allergy Rhinol. 2020 Aug;10(8):944-950
pubmed: 32301284
Chem Senses. 2020 Oct 9;45(7):609-622
pubmed: 32564071
Nat Neurosci. 2021 Feb;24(2):168-175
pubmed: 33257876
Chem Senses. 2006 May;31(4):379-91
pubmed: 16527871
Laryngoscope. 2018 Jan;128(1):10-15
pubmed: 28556265
Laryngoscope. 2014 Apr;124(4):826-31
pubmed: 23929687
Otolaryngol Head Neck Surg. 2021 Mar;164(3):512-518
pubmed: 32867582
Int J Infect Dis. 2020 Nov;100:117-122
pubmed: 32771635
Eur J Neurol. 2020 Sep;27(9):1738-1741
pubmed: 32320508
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
Adv Otorhinolaryngol. 2006;63:125-132
pubmed: 16733337
Otolaryngol Head Neck Surg. 2020 Jul;163(1):114-120
pubmed: 32423357
Arch Otolaryngol Head Neck Surg. 2005 Nov;131(11):977-81
pubmed: 16301369
Lancet Infect Dis. 2020 Sep;20(9):1014-1015
pubmed: 32304632
Nat Med. 2020 Jul;26(7):1037-1040
pubmed: 32393804
Rhinology. 2020 Dec 1;58(6):623-625
pubmed: 32812014
Sci Adv. 2020 Jul 31;6(31):
pubmed: 32937591
Clin Microbiol Infect. 2020 Oct;26(10):1426-1427
pubmed: 32447049
Otolaryngol Clin North Am. 2004 Dec;37(6):1159-66
pubmed: 15563908
Otolaryngol Head Neck Surg. 2020 Jul;163(1):132-134
pubmed: 32340555
Acad Radiol. 2020 Jun;27(6):892-893
pubmed: 32295727
Neuron. 2020 Jul 22;107(2):219-233
pubmed: 32640192
J Neurol. 2021 May;268(5):1570-1572
pubmed: 32767117
Mayo Clin Proc. 2020 Aug;95(8):1621-1631
pubmed: 32753137
Nature. 2020 Sep;585(7824):268-272
pubmed: 32396922
Arch Neurol. 2003 Apr;60(4):545-9
pubmed: 12707068
Chem Senses. 2020 Dec 5;45(9):865-874
pubmed: 33245136
Cell. 2020 Apr 16;181(2):271-280.e8
pubmed: 32142651
Arch Otolaryngol Head Neck Surg. 2009 Oct;135(10):1000-4
pubmed: 19841338
Int J Oral Sci. 2020 Feb 24;12(1):8
pubmed: 32094336
Int Forum Allergy Rhinol. 2020 Jul;10(7):821-831
pubmed: 32329222
PLoS One. 2021 Sep 24;16(9):e0256998
pubmed: 34559820
Rhinol Suppl. 2017 Mar;54(26):1-30
pubmed: 29528615
JAMA Otolaryngol Head Neck Surg. 2020 Jul 1;146(7):674-675
pubmed: 32267483
Clin Anat. 2014 Jan;27(1):54-60
pubmed: 24272785
Clin Otolaryngol. 2020 Nov;45(6):914-922
pubmed: 32741085
Chem Senses. 2020 May 14;:
pubmed: 32407464