NfL levels predominantly increase at disease onset in MOG-Abs-associated disorders.

Autoantibodies Humans Myelin-Oligodendrocyte Glycoprotein
MOG MOGAD Myelitis Neurofilament light chain levels NfL Optic neuritis

Journal

Multiple sclerosis and related disorders
ISSN: 2211-0356
Titre abrégé: Mult Scler Relat Disord
Pays: Netherlands
ID NLM: 101580247

Informations de publication

Date de publication:
May 2021
Historique:
received: 09 11 2020
revised: 02 02 2021
accepted: 04 02 2021
pubmed: 19 2 2021
medline: 15 5 2021
entrez: 18 2 2021
Statut: ppublish

Résumé

The unpredictable course and uncertain impact of relapses make treatment strategies of anti-myelin oligodendrocyte glycoprotein antibodies associated disorders (MOGAD) challenging. We analysed neurofilament light chain levels (NfL) in onset and follow-up sera of 18 patients with MOGAD to clarify the timing of axonal damage. In comparison with disease onset values (median 8.9 pg/mL, range 1.8-97), NfL levels remained stable or decreased in most follow-up measurements (n=52, median 6.7 pg/mL, range 0.2-207), including those measured on relapses. The predominant axonal damage occurs during onset, which could be the main driving factor of final disability, with subsequent relevant clinical and therapeutic implications.

Identifiants

DOI: 10.1016/j.msard.2021.102833 PMID: 33601213
pubmed: 33601213
pii: S2211-0348(21)00099-7
doi: 10.1016/j.msard.2021.102833
pii:
doi:

Substances chimiques

Autoantibodies 0
Myelin-Oligodendrocyte Glycoprotein 0

Types de publication

Letter

Langues

eng

Sous-ensembles de citation

IM

Pagination

102833

Informations de copyright

Copyright © 2021 Elsevier B.V. All rights reserved.

Auteurs

Sara Mariotto (S)

Section of Neurology, Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy. Electronic address: sara.mariotto@gmail.com.

Matteo Gastaldi (M)

Laboratory of Neuroimmunology, IRCCS, National Neurological Insitute C. Mondino Foundation, Pavia, Italy.

Luisa Grazian (L)

Pediatric Unit, ULSS 2 Marca Trevigiana, Ca' Foncello Hospital, Treviso, Italy.

Chiara Mancinelli (C)

Multiple Sclerosis Center, ASST - Spedali Civili of Brescia, Montichiari, Brescia, Italy.

Ruggero Capra (R)

Multiple Sclerosis Center, ASST - Spedali Civili of Brescia, Montichiari, Brescia, Italy.

Romain Marignier (R)

Service de Neurologie, Sclérose en Plaques, Pathologies de la Myéline et Neuro-inflammation, and Centre de Référence des Maladies Inflammatoires Rares du Cerveau et de la Moelle, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon, France.

Daniela Alberti (D)

Section of Neurology, Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.

Serena Zanzoni (S)

Centro Piattaforme Tecnologiche, University of Verona, Italy.

Kathrin Schanda (K)

Clinical Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.

Diego Franciotta (D)

Laboratory of Neuroimmunology, IRCCS, National Neurological Insitute C. Mondino Foundation, Pavia, Italy.

Francesca Calabria (F)

Neurology Unit, AOUI Verona, Verona, Italy.

Salvatore Monaco (S)

Section of Neurology, Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.

Markus Reindl (M)

Clinical Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.

Sergio Ferrari (S)

Section of Neurology, Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.

Alberto Gajofatto (A)

Section of Neurology, Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Autoanticorps › NfL levels predominantly increase at disease...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › NfL levels predominantly increase at disease...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Autoantigènes › Glycoprotéine MOG › NfL levels predominantly increase at disease...