B cells and cancer: To B or not to B?
Journal
The Journal of experimental medicine
ISSN: 1540-9538
Titre abrégé: J Exp Med
Pays: United States
ID NLM: 2985109R
Informations de publication
Date de publication:
04 01 2021
04 01 2021
Historique:
received:
19
07
2020
revised:
02
09
2020
accepted:
17
09
2020
entrez:
18
2
2021
pubmed:
19
2
2021
medline:
31
8
2021
Statut:
ppublish
Résumé
Whereas T cells have been considered the major immune cells of the tumor microenvironment able to induce tumor regression and control cancer clinical outcome, a burst of recent publications pointed to the fact that B cells may also play a prominent role. Activated in germinal centers of tertiary lymphoid structures, B cells can directly present tumor-associated antigens to T cells or produce antibodies that increase antigen presentation to T cells or kill tumor cells, resulting in a beneficial clinical impact. Immune complexes can also increase inflammation, angiogenesis, and immunosuppression via macrophage and complement activation, resulting in deleterious impact.
Identifiants
pubmed: 33601413
pii: 211614
doi: 10.1084/jem.20200851
pmc: PMC7754675
pii:
doi:
Substances chimiques
Antigens, Neoplasm
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2020 Fridman et al.
Déclaration de conflit d'intérêts
Disclosures: T.W.-W. Chen reported personal fees from Novartis, Roche, Eli Lilly, Daiichi Sankyio, and Eisai outside the submitted work. No other disclosures were reported.
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