KPT-330 Prevents Aortic Valve Calcification via a Novel C/EBPβ Signaling Pathway.

Animals Aortic Valve / pathology Aortic Valve Stenosis / drug therapy Axin Protein / metabolism CCAAT-Binding Factor Calcinosis / drug therapy Drug Repositioning Hydrazines / therapeutic use Karyopherins / antagonists & inhibitors Klotho Proteins Mice Receptors, Cytoplasmic and Nuclear / antagonists & inhibitors Triazoles / therapeutic use Wnt Signaling Pathway Exportin 1 Protein
heart valves mass spectrometry signal transduction transcription factors valve disease

Journal

Circulation research
ISSN: 1524-4571
Titre abrégé: Circ Res
Pays: United States
ID NLM: 0047103

Informations de publication

Date de publication:
30 04 2021
Historique:
pubmed: 20 2 2021
medline: 7 1 2022
entrez: 19 2 2021
Statut: ppublish

Résumé

[Figure: see text].

Identifiants

DOI: 10.1161/CIRCRESAHA.120.318503 PMID: 33601919 PMC: PMC8085092
pubmed: 33601919
doi: 10.1161/CIRCRESAHA.120.318503
pmc: PMC8085092
mid: NIHMS1675999
doi:

Substances chimiques

Axin Protein 0
Axin1 protein, mouse 0
CCAAT-Binding Factor 0
Hydrazines 0
Karyopherins 0
Klb protein, mouse 0
Receptors, Cytoplasmic and Nuclear 0
Triazoles 0
selinexor 31TZ62FO8F
Klotho Proteins EC 3.2.1.31

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1300-1316

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL132801
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL142685
Pays : United States

Commentaires et corrections

Type : CommentIn

Références

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Auteurs

Punashi Dutta (P)

Department of Pediatrics, Medical College of Wisconsin, Milwaukee (P.D., K.M.K., K.T., J.L.).
Pediatric Cardiology, The Herma Heart Institute, Children's Wisconsin, Milwaukee (P.D., K.M.K., K.T., J.L.).

Karthik M Kodigepalli (KM)

Department of Pediatrics, Medical College of Wisconsin, Milwaukee (P.D., K.M.K., K.T., J.L.).
Pediatric Cardiology, The Herma Heart Institute, Children's Wisconsin, Milwaukee (P.D., K.M.K., K.T., J.L.).

Stephanie LaHaye (S)

The Institute for Genomic Medicine at Nationwide Children's Hospital, Columbus, OH (S.L.).

J Will Thompson (JW)

Pharmacology and Cancer Biology, Duke University, Durham, NC (J.W.T., S.R.).

Sarah Rains (S)

Pharmacology and Cancer Biology, Duke University, Durham, NC (J.W.T., S.R.).
Duke Proteomics and Metabolomics Shared Resource, Durham, NC (S.R.).

Casey Nagel (C)

Ocean Ridge Biosciences, Deerfield Beach, FL (C.N.).

Kaitlyn Thatcher (K)

Department of Pediatrics, Medical College of Wisconsin, Milwaukee (P.D., K.M.K., K.T., J.L.).
Pediatric Cardiology, The Herma Heart Institute, Children's Wisconsin, Milwaukee (P.D., K.M.K., K.T., J.L.).

Robert B Hinton (RB)

Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center, OH (R.B.H.).

Joy Lincoln (J)

Department of Pediatrics, Medical College of Wisconsin, Milwaukee (P.D., K.M.K., K.T., J.L.).
Pediatric Cardiology, The Herma Heart Institute, Children's Wisconsin, Milwaukee (P.D., K.M.K., K.T., J.L.).

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › KPT-330 Prevents Aortic Valve Calcification...
questionsmedicales.fr › Système cardiovasculaire › Coeur › Valves cardiaques › Valve aortique › KPT-330 Prevents Aortic Valve Calcification...
questionsmedicales.fr › Maladies cardiovasculaires › Cardiopathies › Obstacle à l'éjection ventriculaire › Sténose aortique › KPT-330 Prevents Aortic Valve Calcification...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Complexe de signalisation de l'axine › Axine › KPT-330 Prevents Aortic Valve Calcification...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique et à glissière à leucines › Protéines liant les séquences stimulatrices de type CCAAT › Facteur de liaison à la séquence CCAAT › KPT-330 Prevents Aortic Valve Calcification...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles du métabolisme du calcium › Calcinose › KPT-330 Prevents Aortic Valve Calcification...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Repositionnement des médicaments › KPT-330 Prevents Aortic Valve Calcification...
questionsmedicales.fr › Composés chimiques organiques › Hydrazines › KPT-330 Prevents Aortic Valve Calcification...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › Caryophérines › KPT-330 Prevents Aortic Valve Calcification...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur facteur croissance › Récepteur facteur croissance fibroblaste › Protéines Klotho › KPT-330 Prevents Aortic Valve Calcification...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › KPT-330 Prevents Aortic Valve Calcification...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › KPT-330 Prevents Aortic Valve Calcification...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Triazoles › KPT-330 Prevents Aortic Valve Calcification...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Voie de signalisation Wnt › KPT-330 Prevents Aortic Valve Calcification...