Magnitude and Kinetics of T Cell and Antibody Responses During H1N1pdm09 Infection in Inbred Babraham Pigs and Outbred Pigs.
Animals
Antibodies, Viral
/ blood
B-Lymphocytes
/ immunology
Cytokines
/ metabolism
Disease Models, Animal
Histocompatibility Antigens Class I
/ genetics
Host-Pathogen Interactions
Inbreeding
Influenza A Virus, H1N1 Subtype
/ immunology
Kinetics
Orthomyxoviridae Infections
/ blood
Receptors, Antigen, T-Cell, alpha-beta
/ metabolism
Receptors, Antigen, T-Cell, gamma-delta
/ metabolism
Species Specificity
Sus scrofa
T-Lymphocyte Subsets
/ immunology
Viral Load
Virus Shedding
Ab
H1N1pdm09
T cell
gamma delta cells
influenza
lung
pig
swine
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
10
09
2020
accepted:
15
12
2020
entrez:
19
2
2021
pubmed:
20
2
2021
medline:
22
6
2021
Statut:
epublish
Résumé
We have used the pig, a large natural host animal for influenza with many physiological similarities to humans, to characterize αβ, γδ T cell and antibody (Ab) immune responses to the 2009 pandemic H1N1 virus infection. We evaluated the kinetic of virus infection and associated response in inbred Babraham pigs with identical MHC (Swine Leucocyte Antigen) and compared them to commercial outbred animals. High level of nasal virus shedding continued up to days 4 to 5 post infection followed by a steep decline and clearance of virus by day 9. Adaptive T cell and Ab responses were detectable from days 5 to 6 post infection reaching a peak at 9 to 14 days. γδ T cells produced cytokines
Identifiants
pubmed: 33603740
doi: 10.3389/fimmu.2020.604913
pmc: PMC7884753
doi:
Substances chimiques
Antibodies, Viral
0
Cytokines
0
Histocompatibility Antigens Class I
0
Receptors, Antigen, T-Cell, alpha-beta
0
Receptors, Antigen, T-Cell, gamma-delta
0
swine leukocyte antigen
0
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
604913Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/I/00007036
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/I/00007039
Pays : United Kingdom
Organisme : Medical Research Council
ID : G1100085
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/L001330/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/I/00007031
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/I/00007038
Pays : United Kingdom
Informations de copyright
Copyright © 2021 Edmans, McNee, Porter, Vatzia, Paudyal, Martini, Gubbins, Francis, Harley, Thomas, Burt, Morgan, Fuller, Sewell, Charleston, Bailey and Tchilian.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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