Orexins (hypocretins): The intersection between homeostatic and hedonic feeding.
feeding
food reward
food-seeking
hypocretins
orexins
reward
Journal
Journal of neurochemistry
ISSN: 1471-4159
Titre abrégé: J Neurochem
Pays: England
ID NLM: 2985190R
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
revised:
11
02
2021
received:
24
12
2020
accepted:
15
02
2021
pubmed:
21
2
2021
medline:
25
8
2021
entrez:
20
2
2021
Statut:
ppublish
Résumé
Orexins are hypothalamic neuropeptides originally discovered to play a role in the regulation of feeding behaviour. The broad connections of orexin neurons to mesocorticolimbic circuitry suggest they may play a role in mediating reward-related behaviour beyond homeostatic feeding. Here, we review the role of orexin in a variety of eating-related behaviour, with a focus on reward and motivation, and the neural circuits driving these effects. One emerging finding is the involvement of orexins in hedonic and appetitive behaviour towards palatable food, in addition to their role in homeostatic feeding. This review discusses the brain circuitry and possible mechanisms underlying the role of orexins in these behaviours. Overall, there is a marked bias in the literature towards studies involving male subjects. As such, future work needs to be done to involve female subjects. In summary, orexins play an important role in driving motivation for high salient rewards such as highly palatable food and may serve as the intersection between homeostatic and hedonic feeding.
Substances chimiques
Orexin Receptors
0
Orexins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1473-1494Informations de copyright
© 2021 International Society for Neurochemistry.
Références
Akimoto-Takano, S., Sakurai, C., Kanai, S., Hosoya, H., Ohta, M., & Miyasaka, K. (2005). Differences in the appetite-stimulating effect of orexin, neuropeptide Y and ghrelin among young, adult and old rats. Neuroendocrinology, 82, 256-263. https://doi.org/10.1159/000092754
Akiyama, M., Yuasa, T., Hayasaka, N., Horikawa, K., Sakurai, T., & Shibata, S. (2004). Reduced food anticipatory activity in genetically orexin (hypocretin) neuron-ablated mice. The European Journal of Neuroscience, 20, 3054-3062. https://doi.org/10.1111/j.1460-9568.2004.03749.x
Alcaraz-Iborra, M., Carvajal, F., Lerma-Cabrera, J. M., Valor, L. M., & Cubero, I. (2014). Binge-like consumption of caloric and non-caloric palatable substances in ad libitum-fed C57BL/6J mice: Pharmacological and molecular evidence of orexin involvement. Behavioural Brain Research, 272, 93-99. https://doi.org/10.1016/j.bbr.2014.06.049
Alvarez-Crespo, M., Martinez-Sanchez, N., Ruiz-Pino, F., Garcia-Lavandeira, M., Alvarez, C. V., Tena-Sempere, M., Nogueiras, R., Dieguez, C., & Lopez, M. (2013). The orexigenic effect of Orexin-A revisited: Dependence of an intact growth hormone axis. Endocrinology, 154, 3589-3598. https://doi.org/10.1210/en.2013-1251
Anderson, R. I., Becker, H. C., Adams, B. L., Jesudason, C. D., & Rorick-Kehn, L. M. (2014). Orexin-1 and orexin-2 receptor antagonists reduce ethanol self-administration in high-drinking rodent models. Frontiers in Neuroscience, 8, 33., https://doi.org/10.3389/fnins.2014.00033
Arksey, H., & O'Malley, L. (2005). Scoping studies: Towards a methodological framework. International Journal of Social Research Methodology, 8, 19-32. https://doi.org/10.1080/1364557032000119616
Asakawa, A., Inui, A., Inui, T., Katsuura, G., Fujino, M. A., & Kasuga, M. (2002). Orexin reverses cholecystokinin-induced reduction in feeding. Diabetes, Obesity & Metabolism, 4, 399-401. https://doi.org/10.1046/j.1463-1326.2002.00234.x
Baird, J. P., Choe, A., Loveland, J. L., Beck, J., Mahoney, C. E., Lord, J. S., & Grigg, L. A. (2009). Orexin-A hyperphagia: Hindbrain participation in consummatory feeding responses. Endocrinology, 150, 1202-1216. https://doi.org/10.1210/en.2008-0293
Barson, J. R. (2018). Orexin/hypocretin and dysregulated eating: Promotion of foraging behavior. Brain Research, 1731, 145915.
Barson, J. R., Ho, H. T., & Leibowitz, S. F. (2015). Anterior thalamic paraventricular nucleus is involved in intermittent access ethanol drinking: Role of orexin receptor 2. Addiction Biology, 20, 469-481. https://doi.org/10.1111/adb.12139
Barson, J. R., Poon, K., Ho, H. T., Alam, M. I., Sanzalone, L., & Leibowitz, S. F. (2017). Substance P in the anterior thalamic paraventricular nucleus: Promotion of ethanol drinking in response to orexin from the hypothalamus. Addiction Biology, 22, 58-69. https://doi.org/10.1111/adb.12288
Benoit, S. C., Clegg, D. J., Woods, S. C., & Seeley, R. J. (2005). The role of previous exposure in the appetitive and consummatory effects of orexigenic neuropeptides. Peptides, 26, 751-757. https://doi.org/10.1016/j.peptides.2004.12.012
Berridge, K. C. (2009). 'Liking' and 'wanting' food rewards: Brain substrates and roles in eating disorders. Physiology & Behavior, 97, 537-550.
Borgland, S. L., Chang, S.-J., Bowers, M. S., Thompson, J. L., Vittoz, N., Floresco, S. B., Chou, J., Chen, B. T., & Bonci, A. (2009). Orexin A/hypocretin-1 selectively promotes motivation for positive reinforcers. Journal of Neuroscience, 29, 11215-11225. https://doi.org/10.1523/JNEUROSCI.6096-08.2009
Borgland, S. L., Taha, S. A., Sarti, F., Fields, H. L., & Bonci, A. (2006). Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine. Neuron, 49, 589-601. https://doi.org/10.1016/j.neuron.2006.01.016
Briski, K. P., & Sylvester, P. W. (2001). Hypothalamic Orexin-A-immunpositive neurons express Fos in response to central glucopenia. NeuroReport, 12, 531-534. https://doi.org/10.1097/00001756-200103050-00020
Brown, R. M., Khoo, S. Y., & Lawrence, A. J. (2013). Central orexin (hypocretin) 2 receptor antagonism reduces ethanol self-administration, but not cue-conditioned ethanol-seeking, in ethanol-preferring rats. The International Journal of Neuropsychopharmacology, 16, 2067-2079. https://doi.org/10.1017/S1461145713000333
Buczek, L., Migliaccio, J., & Petrovich, G. D. (2020). Hedonic eating: Sex differences and characterization of orexin activation and signaling. Neuroscience, 436, 34-45. https://doi.org/10.1016/j.neuroscience.2020.04.008
Bulbul, M., Tan, R., Gemici, B., Ozdem, S., Ustunel, I., Acar, N., & Izgut-Uysal, V. N. (2010). Endogenous Orexin-A modulates gastric motility by peripheral mechanisms in rats. Peptides, 31, 1099-1108. https://doi.org/10.1016/j.peptides.2010.03.007
Burdakov, D., Gerasimenko, O., & Verkhratsky, A. (2005). Physiological changes in glucose differentially modulate the excitability of hypothalamic melanin-concentrating hormone and orexin neurons in situ. Journal of Neuroscience, 25, 2429-2433.
Cai, X. J., Denis, R., Vernon, R. G., Clapham, J. C., Wilson, S., Arch, J. R. S., & Williams, G. (2001). Food restriction selectively increases hypothalamic orexin-B levels in lactating rats. Regulatory Peptides, 97, 163-168. https://doi.org/10.1016/S0167-0115(00)00209-3
Cai, X. J., Evans, M. L., Lister, C. A., Leslie, R. A., Arch, J. R. S., Wilson, S., & Williams, G. (2001). Hypoglycemia activates orexin neurons and selectively increases hypothalamic orexin-B levels - Responses inhibited by feeding and possibly mediated by the nucleus of the solitary tract. Diabetes, 50, 105-112. https://doi.org/10.2337/diabetes.50.1.105
Cai, X. J., Widdowson, P. S., Harrold, J., Wilson, S., Buckingham, R. E., Arch, J. R., Tadayyon, M., Clapham, J. C., Wilding, J., & Williams, G. (1999). Hypothalamic orexin expression - modulation by blood glucose and feeding. Diabetes, 48, 2132-2137. https://doi.org/10.2337/diabetes.48.11.2132
Calvez, J., Lenglos, C., de Avila, C., Guevremont, G., & Timofeeva, E. (2015). Differential effects of central administration of relaxin-3 on food intake and hypothalamic neuropeptides in male and female rats. Genes, Brain, and Behavior, 14, 550-563. https://doi.org/10.1111/gbb.12236
Cason, A. M., & Aston-Jones, G. (2013a). Attenuation of saccharin-seeking in rats by orexin/hypocretin receptor 1 antagonist. Psychopharmacology (Berl), 228, 499-507. https://doi.org/10.1007/s00213-013-3051-7
Cason, A. M., & Aston-Jones, G. (2013b). Role of orexin/hypocretin in conditioned sucrose-seeking in rats. Psychopharmacology (Berl), 226, 155-165. https://doi.org/10.1007/s00213-012-2902-y
Cason, A. M., & Aston-Jones, G. (2014). Role of orexin/hypocretin in conditioned sucrose-seeking in female rats. Neuropharmacology, 86, 97-102. https://doi.org/10.1016/j.neuropharm.2014.07.007
Castro, D. C., Terry, R. A., & Berridge, K. C. (2016). Orexin in rostral hotspot of nucleus accumbens enhances sucrose 'Liking' and intake but scopolamine in caudal shell shifts 'Liking' toward 'Disgust' and 'Fear'. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology, 41, 2101-2111. https://doi.org/10.1038/npp.2016.10
Choi, D. L., Davis, J. F., Fitzgerald, M. E., & Benoit, S. C. (2010). The role of Orexin-A in food motivation, reward-based feeding behavior and food-induced neuronal activation in rats. Neuroscience, 167, 11-20. https://doi.org/10.1016/j.neuroscience.2010.02.002
Choi, D. L., Davis, J. F., Magrisso, I. J., Fitzgerald, M. E., Lipton, J. W., & Benoit, S. C. (2012). Orexin signaling in the paraventricular thalamic nucleus modulates mesolimbic dopamine and hedonic feeding in the rat. Neuroscience, 210, 243-248. https://doi.org/10.1016/j.neuroscience.2012.02.036
Clegg, D. J., Air, E. L., Woods, S. C., & Seeley, R. J. (2002). Eating elicited by Orexin-A, but not melanin-concentrating hormone, is opioid mediated. Endocrinology, 143, 2995-3000. https://doi.org/10.1210/endo.143.8.8977
Cole, S., Keefer, S. E., Anderson, L. C., & Petrovich, G. D. (2020). Medial prefrontal cortex neural plasticity, orexin receptor 1 signaling, and connectivity with the lateral hypothalamus are necessary in cue-potentiated feeding. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 40, 1744-1755. https://doi.org/10.1523/JNEUROSCI.1803-19.2020
Cole, S., Mayer, H. S., & Petrovich, G. D. (2015). Orexin/hypocretin-1 receptor antagonism selectively reduces cue-induced feeding in sated rats and recruits medial prefrontal cortex and thalamus. Scientific Reports, 5, 11, https://doi.org/10.1038/srep16143
Crespo, I., Gomez de Heras, R., Rodriguez de Fonseca, F., & Navarro, M. (2008). Pretreatment with subeffective doses of Rimonabant attenuates orexigenic actions of orexin A-hypocretin 1. Neuropharmacology, 54, 219-225. https://doi.org/10.1016/j.neuropharm.2007.05.027
de Lecea, L., Kilduff, T. S., Peyron, C., Gao, X.-B., Foye, P. E., Danielson, P. E., Fukuhara, C., Battenberg, E. L. F., Gautvik, V. T., Bartlett, F. S., Frankel, W. N., van den Pol, A. N., Bloom, F. E., Gautvik, K. M., & Sutcliffe, J. G. (1998). The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity. Proceedings of the National Academy of Sciences of the United States of America, 95, 322-327. https://doi.org/10.1073/pnas.95.1.322
Dhuria, S. V., Fine, J. M., Bingham, D., Svitak, A. L., Burns, R. B., Baillargeon, A. M., Panter, S. S., Kazi, A. N., Frey, W. H., & Hanson, L. R. (2016). Food consumption and activity levels increase in rats following intranasal Hypocretin-1. Neuroscience Letters, 627, 155-159. https://doi.org/10.1016/j.neulet.2016.05.053
Doane, D. F., Lawson, M. A., Meade, J. R., Kotz, C. M., & Beverly, J. L. (2007). Orexin-induced feeding requires NMDA receptor activation in the perifornical region of the lateral hypothalamus. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 293, R1022-1026. https://doi.org/10.1152/ajpregu.00282.2007
Dube, M. G., Kalra, S. P., & Kalra, P. S. (1999). Food intake elicited by central administration of orexins/hypocretins: Identification of hypothalamic sites of action. Brain Research, 842, 473-477.
Edwards, C. M. B., Abusnana, S., Sunter, D., Murphy, K. G., Ghatel, M. A., & Bloom, S. R. (1999). The effect of the orexins on food intake: Comparison with neuropeptide Y, melanin-concentrating hormone and galanin. Journal of Endocrinology, 160, R7-R12. https://doi.org/10.1677/joe.0.160r007
Espana, R. A., Plahn, S., & Berridge, C. W. (2002). Circadian-dependent and circadian-independent behavioral actions of hypocretin/orexin. Brain Research, 943, 224-236. https://doi.org/10.1016/S0006-8993(02)02653-7
Farr, S. A., Banks, W. A., Kumar, V. B., & Morley, J. E. (2005). Orexin-A-induced feeding is dependent on nitric oxide. Peptides, 26, 759-765. https://doi.org/10.1016/j.peptides.2004.12.004
Feillet, C. A., Bainier, C., Mateo, M., Blancas-Velazquez, A., Salaberry, N. L., Ripperger, J. A., Albrecht, U., & Mendoza, J. (2017). Rev-erbalpha modulates the hypothalamic orexinergic system to influence pleasurable feeding behaviour in mice. Addiction Biology, 22, 411-422.
Ferry, B., & Duchamp-Viret, P. (2014). The orexin component of fasting triggers memory processes underlying conditioned food selection in the rat. Learning & Memory (Cold Spring Harbor, N.Y.), 21, 185-189.
Fields, H. L., Hjelmstad, G. O., Margolis, E. B., & Nicola, S. M. (2007). Ventral tegmental area neurons in learned appetitive behavior and positive reinforcement. Annual Review of Neuroscience, 30, 289-316. https://doi.org/10.1146/annurev.neuro.30.051606.094341
Ford, G. K., Al-Barazanji, K. A., Wilson, S., Jones, D. N., Harbuz, M. S., & Jessop, D. S. (2005). Orexin expression and function: Glucocorticoid manipulation, stress, and feeding studies. Endocrinology, 146, 3724-3731. https://doi.org/10.1210/en.2005-0496
Frederick-Duus, D., Guyton, M. F., & Fadel, J. (2007). Food-elicited increases in cortical acetylcholine release require orexin transmission. Neuroscience, 149, 499-507. https://doi.org/10.1016/j.neuroscience.2007.07.061
Freeman, L. R., Bentzley, B. S., James, M. H., & Aston-Jones, G. (2021). Sex differences in demand for highly palatable foods: Role of the orexin system. International Journal of Neuropsychopharmacology, 24(1), 54-63.
Fukushima, A., Hagiwara, H., Fujioka, H., Kimura, F., Akema, T., & Funabashi, T. (2015). Sex differences in feeding behavior in rats: The relationship with neuronal activation in the hypothalamus. Frontiers in Neuroscience, 9, 88, https://doi.org/10.3389/fnins.2015.00088
Funabashi, T., Hagiwara, H., Mogi, K., Mitsushima, D., Shinohara, K., & Kimura, F. (2009). Sex differences in the responses of orexin neurons in the lateral hypothalamic area and feeding behavior to fasting. Neuroscience Letters, 463, 31-34. https://doi.org/10.1016/j.neulet.2009.07.035
Furudono, Y., Ando, C., Yamamoto, C., Kobashi, M., & Yamamoto, T. (2006). Involvement of specific orexigenic neuropeptides in sweetener-induced overconsumption in rats. Behavioural Brain Research, 175, 241-248. https://doi.org/10.1016/j.bbr.2006.08.031
Gac, L., Butterick, T. A., Duffy, C. M., Teske, J. A., & Perez-Leighton, C. E. (2016). Role of the non-opioid dynorphin peptide des-Tyr-dynorphin (DYN-A(2-17)) in food intake and physical activity, and its interaction with Orexin-A. Peptides, 76, 14-18. https://doi.org/10.1016/j.peptides.2015.12.001
Garcia-Luna, C., Amaya, M. I., Alvarez-Salas, E., & de Gortari, P. (2010). Prepro-orexin and feeding-related peptide receptor expression in dehydration-induced anorexia. Regulatory Peptides, 159, 54-60. https://doi.org/10.1016/j.regpep.2009.09.011
Gonzalez, J. A., Jensen, L. T., Iordanidou, P., Strom, M., Fugger, L., & Burdakov, D. (2016). Inhibitory interplay between orexin neurons and eating. Current Biology, 26, 2486-2491. https://doi.org/10.1016/j.cub.2016.07.013
Grafe, L. A., Cornfeld, A., Luz, S., Valentino, R., & Bhatnagar, S. (2017). Orexins mediate sex differences in the stress response and in cognitive flexibility. Biological Psychiatry, 81, 683-692. https://doi.org/10.1016/j.biopsych.2016.10.013
Grafe, L. A., Geng, E., Corbett, B., Urban, K., & Bhatnagar, S. (2019). Sex- and stress-dependent effects on dendritic morphology and spine densities in putative orexin neurons. Neuroscience, 418, 266-278. https://doi.org/10.1016/j.neuroscience.2019.08.026
Griffond, B., Risold, P. Y., Jacquemard, C., Colard, C., & Fellmann, D. (1999). Insulin-induced hypoglycemia increases preprohypocretin (orexin) mRNA in the rat lateral hypothalamic area. Neuroscience Letters, 262, 77-80. https://doi.org/10.1016/S0304-3940(98)00976-8
Guerdjikova, A. I., Mori, N., Casuto, L. S., & McElroy, S. L. (2017). Binge eating disorder. The Psychiatric Clinics of North America, 40, 255-266. https://doi.org/10.1016/j.psc.2017.01.003
Hagar, J. M., Macht, V. A., Wilson, S. P., & Fadel, J. R. (2017). Upregulation of orexin/hypocretin expression in aged rats: Effects on feeding latency and neurotransmission in the insular cortex. Neuroscience, 350, 124-132. https://doi.org/10.1016/j.neuroscience.2017.03.021
Haight, J. L., Campus, P., Maria-Rios, C. E., Johnson, A. M., Klumpner, M. S., Kuhn, B. N., Covelo, I. R., Morrow, J. D., & Flagel, S. B. (2020). The lateral hypothalamus and orexinergic transmission in the paraventricular thalamus promote the attribution of incentive salience to reward-associated cues. Psychopharmacology (Berl), 237(12), 3741-3758.
Hara, J., Beuckmann, C. T., Nambu, T., Willie, J. T., Chemelli, R. M., Sinton, C. M., Sugiyama, F., Yagami, K.-I., Goto, K., Yanagisawa, M., & Sakurai, T. (2001). Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity. Neuron, 30, 345-354. https://doi.org/10.1016/S0896-6273(01)00293-8
Harris, G. C., Wimmer, M., & Aston-Jones, G. (2005). A role for lateral hypothalamic orexin neurons in reward seeking. Nature, 437, 556-559. https://doi.org/10.1038/nature04071
Hassani, O. K., Krause, M. R., Mainville, L., Cordova, C. A., & Jones, B. E. (2016). Orexin neurons respond differentially to auditory cues associated with appetitive versus aversive outcomes. Journal of Neuroscience, 36, 1747-1757.
Haynes, A. C., Chapman, H., Taylor, C., Moore, G. B. T., Cawthorne, M. A., Tadayyon, M., Clapham, J. C., & Arch, J. R. S. (2002). Anorectic, thermogenic and anti-obesity activity of a selective orexin-1 receptor antagonist in ob/ob mice. Regulatory Peptides, 104, 153-159. https://doi.org/10.1016/S0167-0115(01)00358-5
Haynes, A. C., Jackson, B., Chapman, H., Tadayyon, M., Johns, A., Porter, R. A., & Arch, J. R. S. (2000). A selective orexin-1 receptor antagonist reduces food consumption in male and female rats. Regulatory Peptides, 96, 45-51. https://doi.org/10.1016/S0167-0115(00)00199-3
Haynes, A. C., Jackson, B., Overend, P., Buckingham, R. E., Wilson, S., Tadayyon, M., & Arch, J. R. S. (1999). Effects of single and chronic intracerebroventricular administration of the orexins on feeding in the rat. Peptides, 20, 1099-1105. https://doi.org/10.1016/S0196-9781(99)00105-9
Hopf, F. W. (2020). Recent perspectives on orexin/hypocretin promotion of addiction-related behaviors. Neuropharmacology, 168, 108013.-https://doi.org/10.1016/j.neuropharm.2020.108013
Hsu, T. M., Hahn, J. D., Konanur, V. R., Noble, E. E., Suarez, A. N., Thai, J., Nakamoto, E. M., & Kanoski, S. E. (2015). Hippocampus ghrelin signaling mediates appetite through lateral hypothalamic orexin pathways. eLife, 4, e11190. https://doi.org/10.7554/eLife.11190
Ida, T., Nakahara, K., Katayama, T., Murakami, N., & Nakazato, M. (1999). Effect of lateral cerebroventricular injection of the appetite-stimulating neuropeptide, orexin and neuropeptide Y, on the various behavioral activities of rats. Brain Research, 821, 526-529. https://doi.org/10.1016/S0006-8993(99)01131-2
Ida, T., Nakahara, K., Kuroiwa, T., Fukui, K., Nakazato, M., Murakami, T., & Murakami, N. (2000). Both corticotropin releasing factor and neuropeptide Y are involved in the effect of orexin (hypocretin) on the food intake in rats. Neuroscience Letters, 293, 119-122. https://doi.org/10.1016/S0304-3940(00)01498-1
Ishii, Y., Blundell, J. E., Halford, J. C., Upton, N., Porter, R., Johns, A., Jeffrey, P., Summerfield, S., & Rodgers, R. J. (2005a). Anorexia and weight loss in male rats 24 h following single dose treatment with orexin-1 receptor antagonist SB-334867. Behavioural Brain Research, 157, 331-341. https://doi.org/10.1016/j.bbr.2004.07.012
Ishii, Y., Blundell, J. E., Halford, J. C. G., Upton, N., Porter, R., Johns, A., & Rodgers, R. J. (2004). Differential effects of the selective orexin-1 receptor antagonist SB-334867 and lithium chloride on the behavioural satiety sequence in rats. Physiology & Behavior, 81, 129-140. https://doi.org/10.1016/j.physbeh.2004.01.009
Ishii, Y., Blundell, J. E., Halford, J. C. G., Upton, N., Porter, R., Johns, A., & Rodgers, R. J. (2005b). Satiety enhancement by selective orexin-1 receptor antagonist SB-334867: Influence of test context and profile comparison with CCK-8S. Behavioural Brain Research, 160, 11-24. https://doi.org/10.1016/j.bbr.2004.11.011
Jain, M. R., Horvath, T. L., Kalra, P. S., & Kalra, S. P. (2000). Evidence that NPY Y1 receptors are involved in stimulation of feeding by orexins (hypocretins) in sated rats. Regulatory Peptides, 87, 19-24. https://doi.org/10.1016/S0167-0115(99)00102-0
James, M. H., Campbell, E. J., & Dayas, C. V. (2017). Role of the orexin/hypocretin system in stress-related psychiatric disorders. Current Topics in Behavioral Neurosciences, 33, 197-219.
Jimenez, A., Caba, M., & Escobar, C. (2013). Food-entrained patterns in orexin cells reveal subregion differential activation. Brain Research, 1513, 41-50. https://doi.org/10.1016/j.brainres.2013.03.031
Jin, T. T., Jiang, Z. X., Luan, X., Qu, Z. L., Guo, F. F., Gao, S. L., Xu, L., & Sun, X. R. (2020). Exogenous Orexin-A microinjected into central nucleus of the amygdala modulates feeding and gastric motility in rats. Frontiers in Neuroscience, 14., https://doi.org/10.3389/fnins.2020.00274
Johnstone, L. E., Fong, T. M., & Leng, G. (2006). Neuronal activation in the hypothalamus and brainstem during feeding in rats. Cell Metabolism, 4, 313-321. https://doi.org/10.1016/j.cmet.2006.08.003
Johren, O., Bruggemann, N., Dendorfer, A., & Dominiak, P. (2003). Gonadal steroids differentially regulate the messenger ribonucleic acid expression of pituitary orexin type 1 receptors and adrenal orexin type 2 receptors. Endocrinology, 144, 1219-1225. https://doi.org/10.1210/en.2002-0030
Jöhren, O., Neidert, S. J., Kummer, M., & Dominiak, P. (2002). Sexually dimorphic expression of prepro-orexin mRNA in the rat hypothalamus. Peptides, 23, 1177-1180. https://doi.org/10.1016/S0196-9781(02)00052-9
Joibari, M. M., & Khazali, H. (2013). Effect of stress on fasting-induced ghrelin, orexin and galanin secretion in male rats fed different levels of their energy requirement. Obesity (Silver Spring, Md.), 21, 130-134.
Jorgensen, E. A., Knigge, U., Watanabe, T., Warberg, J., & Kjaer, A. (2005). Histaminergic neurons are involved in the orexigenic effect of Orexin-A. Neuroendocrinology, 82, 70-77. https://doi.org/10.1159/000090982
Julliard, A. K., Chaput, M. A., Apelbaum, A., Aime, P., Mahfouz, M., & Duchamp-Viret, P. (2007). Changes in rat olfactory detection performance induced by orexin and leptin mimicking fasting and satiation. Behavioural Brain Research, 183, 123-129. https://doi.org/10.1016/j.bbr.2007.05.033
Jupp, B., Krivdic, B., Krstew, E., & Lawrence, A. J. (2011). The orexin(1) receptor antagonist SB-334867 dissociates the motivational properties of alcohol and sucrose in rats. Brain Research, 1391, 54-59. https://doi.org/10.1016/j.brainres.2011.03.045
Karasawa, H., Yakabi, S., Wang, L. X., & Tache, Y. (2014). Orexin-1 receptor mediates the increased food and water intake induced by intracerebroventricular injection of the stable somatostatin pan-agonist, ODT8-SST in rats. Neuroscience Letters, 576, 88-92. https://doi.org/10.1016/j.neulet.2014.05.063
Karteris, E., Machado, R. J., Chen, J., Zervou, S., Hillhouse, E. W., & Randeva, H. S. (2005). Food deprivation differentially modulates orexin receptor expression and signaling in rat hypothalamus and adrenal cortex. American Journal of Physiology-Endocrinology and Metabolism, 288, E1089-1100. https://doi.org/10.1152/ajpendo.00351.2004
Kaur, S., Thankachan, S., Begum, S., Blanco-Centurion, C., Sakurai, T., Yanagisawa, M., & Shiromani, P. J. (2008). Entrainment of temperature and activity rhythms to restricted feeding in orexin knock out mice. Sleep, 31, A361. https://doi.org/10.1016/j.brainres.2008.02.026
Kay, K., Parise, E. M., Lilly, N., & Williams, D. L. (2014). Hindbrain orexin 1 receptors influence palatable food intake, operant responding for food, and food-conditioned place preference in rats. Psychopharmacology (Berl), 231, 419-427. https://doi.org/10.1007/s00213-013-3248-9
Khoo, S.-Y.-S., Clemens, K. J., & McNally, G. P. (2018). Palatable food self-administration and reinstatement are not affected by dual orexin receptor antagonism. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 87, 147-157. https://doi.org/10.1016/j.pnpbp.2017.06.028
Kokare, D. M., Patole, A. M., Carta, A., Chopde, C. T., & Subhedar, N. K. (2006). GABA(A) receptors mediate Orexin-A induced stimulation of food intake. Neuropharmacology, 50, 16-24. https://doi.org/10.1016/j.neuropharm.2005.07.019
Komaki, G., Matsumoto, Y., Nishikata, H., Kawai, K., Nozaki, T., Takii, M., Sogawa, H., & Kubo, C. (2001). Orexin-A and leptin change inversely in fasting non-obese subjects. European Journal of Endocrinology, 144, 645-651. https://doi.org/10.1530/eje.0.1440645
Korotkova, T. M., Sergeeva, O. A., Eriksson, K. S., Haas, H. L., & Brown, R. E. (2003). Excitation of ventral tegmental area dopaminergic and nondopaminergic neurons by orexins/hypocretins. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 23, 7-11. https://doi.org/10.1523/JNEUROSCI.23-01-00007.2003
Kotz, C. M., Mullett, M. A., & Wang, C. F. (2005). Diminished feeding responsiveness to orexin A (hypocretin 1) in aged rats is accompanied by decreased neuronal activation. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 289, R359-R366. https://doi.org/10.1152/ajpregu.00717.2004
Kotz, C. M., Teske, J. A., Levine, J. A., & Wang, C. F. (2002). Feeding and activity induced by orexin A in the lateral hypothalamus in rats. Regulatory Peptides, 104, 27-32. https://doi.org/10.1016/S0167-0115(01)00346-9
Kurose, T., Ueta, Y., Yamamoto, Y., Serino, R., Ozaki, Y., Saito, J., Nagata, S., & Yamashita, H. (2002). Effects of restricted feeding on the activity of hypothalamic Orexin (OX)-A containing neurons and OX2 receptor mRNA level in the paraventricular nucleus of rats. Regulatory Peptides, 104, 145-151. https://doi.org/10.1016/S0167-0115(01)00340-8
Laviano, A., Meguid, M. M., Gleason, J. R., Yang, Z. J., & Renvyle, T. (1996). Comparison of long-term feeding pattern between male and female Fischer 344 rats: Influence of estrous cycle. The American Journal of Physiology, 270, R413-419. https://doi.org/10.1152/ajpregu.1996.270.2.R413
Lebedev, A. A., Bessolova, Y. N., Efimov, N. S., Bychkov, E. R., Droblenkov, A. V., & Shabanov, P. D. (2020). Role of orexin peptide system in emotional overeating induced by brain reward stimulation in fed rats. Research Results in Pharmacology, 6, 81. https://doi.org/10.3897/rrpharmacology.6.52180
Levac, D., Colquhoun, H., & O'Brien, K. K. (2010). Scoping studies: Advancing the methodology. Implementation Science, 5, 1-9. https://doi.org/10.1186/1748-5908-5-69
Li, A. J., Wang, Q., Davis, H., Wang, R., & Ritter, S. (2015). Orexin-A enhances feeding in male rats by activating hindbrain catecholamine neurons. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 309, R358-367. https://doi.org/10.1152/ajpregu.00065.2015
Lu, X. Y., Bagnol, D., Burke, S., Akil, H., & Watson, S. J. (2000). Differential distribution and regulation of OX1 and OX2 orexin/hypocretin receptor messenger RNA in the brain upon fasting. Hormones and Behavior, 37, 335-344. https://doi.org/10.1006/hbeh.2000.1584
Lubkin, M., & Stricker-Krongrad, A. (1998). Independent feeding and metabolic actions of orexins in mice. Biochemical and Biophysical Research Communications, 253, 241-245. https://doi.org/10.1006/bbrc.1998.9750
Mahler, S. V., Moorman, D. E., Smith, R. J., James, M. H., & Aston-Jones, G. (2014). Motivational activation: A unifying hypothesis of orexin/hypocretin function. Nature Neuroscience, 17, 1298-1303. https://doi.org/10.1038/nn.3810
Mahler, S. V., Smith, R. J., Moorman, D. E., Sartor, G. C., & Aston-Jones, G. (2012). Multiple roles for orexin/hypocretin in addiction. Progress in Brain Research, 198, 79-121.
Marcus, J. N., Aschkenasi, C. J., Lee, C. E., Chemelli, R. M., Saper, C. B., Yanagisawa, M., & Elmquist, J. K. (2001). Differential expression of orexin receptors 1 and 2 in the rat brain. The Journal of Comparative Neurology, 435, 6-25. https://doi.org/10.1002/cne.1190
Martin-Fardon, R., Cauvi, G., Kerr, T. M., & Weiss, F. (2018). Differential role of hypothalamic orexin/hypocretin neurons in reward seeking motivated by cocaine versus palatable food. Addiction Biology, 23, 6-15. https://doi.org/10.1111/adb.12441
Martin-Fardon, R., & Weiss, F. (2014a). Blockade of hypocretin receptor-1 preferentially prevents cocaine seeking: Comparison with natural reward seeking. NeuroReport, 25, 485-488. https://doi.org/10.1097/WNR.0000000000000120
Martin-Fardon, R., & Weiss, F. (2014b). N-(2-methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl urea (SB334867), a hypocretin receptor-1 antagonist, preferentially prevents ethanol seeking: Comparison with natural reward seeking. Addiction Biology, 19, 233-236.
Matsuo, E., Mochizuki, A., Nakayama, K., Nakamura, S., Yamamoto, T., Shioda, S., Sakurai, T., Yanagisawa, M., Shiuchi, T., Minokoshi, Y., & Inoue, T. (2011). Decreased intake of sucrose solutions in orexin knockout mice. Journal of Molecular Neuroscience, 43, 217-224. https://doi.org/10.1007/s12031-010-9475-1
Mavanji, V., Perez-Leighton, C. E., Kotz, C. M., Billington, C. J., Parthasarathy, S., Sinton, C. M., & Teske, J. A. (2015). Promotion of wakefulness and energy expenditure by Orexin-A in the ventrolateral preoptic area. Sleep, 38, 1361-1370. https://doi.org/10.5665/sleep.4970
Mayannavar, S., Rashmi, K. S., Rao, Y. D., Yadav, S., & Ganaraja, B. (2014). Effect of Orexin-A infusion in to the nucleus accumbens on consummatory behaviour and alcohol preference in male Wistar rats. Indian Journal of Physiology and Pharmacology, 58, 319-326.
Meffre, J., Sicre, M., Diarra, M., Marchessaux, F., Paleressompoulle, D., & Ambroggi, F. (2019). Orexin in the posterior paraventricular thalamus mediates hunger-related signals in the nucleus accumbens core. Current Biology, 29, 3298-3306.e3294. https://doi.org/10.1016/j.cub.2019.07.069
Mieda, M. (2017). The roles of orexins in sleep/wake regulation. Neuroscience Research, 118, 56-65. https://doi.org/10.1016/j.neures.2017.03.015
Mieda, M., Williams, S. C., Sinton, C. M., Richardson, J. A., Sakurai, T., & Yanagisawa, M. (2004). Orexin neurons function in an efferent pathway of a food-entrainable circadian oscillator in eliciting food-anticipatory activity and wakefulness. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 24, 10493-10501. https://doi.org/10.1523/JNEUROSCI.3171-04.2004
Mistlberger, R. E., Antle, M. C., Kilduff, T. S., & Jones, M. (2003). Food- and light-entrained circadian rhythms in rats with hypocretin-2-saporin ablations of the lateral hypothalamus. Brain Research, 980, 161-168. https://doi.org/10.1016/S0006-8993(03)02755-0
Mitchell, C. S., Fisher, S. D., Yeoh, J. W., Pearl, A. J., Burton, N. J., Bains, J. S., McNally, G. P., Andrews, Z. A., Graham, B. A., & Dayas, C. V. (2020) A ventral striatal-orexin/hypocretin circuit modulates approach but not consumption of food. bioRxiv. https://doi.org/10.1101/2020.03.05.979468
Mizushige, T., Kawai, T., Matsumura, S., Yoneda, T., Kawada, T., Tsuzuki, S., Inoue, K., & Fushiki, T. (2006). POMC and orexin mRNA expressions induced by anticipation of a corn-oil emulsion feeding are maintained at the high levels until oil ingestion. Biomedical Research (Tokyo, Japan), 27, 227-232. https://doi.org/10.2220/biomedres.27.227
Monda, M., Viggiano, A., & De Luca, V. (2003). Parodoxical effect of orexin A: Hypophagia induced by hyperthermia. Brain Research, 961, 220-228. https://doi.org/10.1016/S0006-8993(02)03953-7
Mondal, M. S., Nakazato, M., Date, Y., Murakami, N., Yanagisawa, M., & Matsukura, S. (1999). Widespread distribution of orexin in rat brain and its regulation upon fasting. Biochemical and Biophysical Research Communications, 256, 495-499. https://doi.org/10.1006/bbrc.1999.0362
Moreno, G., Perello, M., Gaillard, R. C., & Spinedi, E. (2005). Orexin a stimulates hypothalamic-pituitary-adrenal (HPA) axis function, but not food intake, in the absence of full hypothalamic NPY-ergic activity. Endocrine, 26, 99-106. https://doi.org/10.1385/ENDO:26:2:099
Morganstern, I., Chang, G. Q., Karatayev, O., & Leibowitz, S. F. (2010). Increased orexin and melanin-concentrating hormone expression in the perifornical lateral hypothalamus of rats prone to overconsuming a fat-rich diet. Pharmacology, Biochemistry and Behavior, 96, 413-422. https://doi.org/10.1016/j.pbb.2010.06.013
Nair, S. G., Golden, S. A., & Shaham, Y. (2008). Differential effects of the hypocretin 1 receptor antagonist SB 334867 on high-fat food self-administration and reinstatement of food seeking in rats. British Journal of Pharmacology, 154, 406-416. https://doi.org/10.1038/bjp.2008.3
Olszewski, P. K., Shaw, T. J., Grace, M. K., Hoglund, C. E., Fredriksson, R., Schioth, H. B., & Levine, A. S. (2009). Complexity of neural mechanisms underlying overconsumption of sugar in scheduled feeding: Involvement of opioids, orexin, oxytocin and NPY. Peptides, 30, 226-233. https://doi.org/10.1016/j.peptides.2008.10.011
Otlivanchik, O., Le Foll, C., & Levin, B. E. (2015). Perifornical hypothalamic orexin and serotonin modulate the counterregulatory response to hypoglycemic and glucoprivic stimuli. Diabetes, 64, 226-235. https://doi.org/10.2337/db14-0671
Park, E. S., Yi, S. J., Kim, J. S., Lee, H. S., Lee, I. S., Seong, J. K., Jin, H. K., & Yoon, Y. S. (2004). Changes in orexin-A and neuropeptide Y expression in the hypothalamus of the fasted and high-fat diet fed rats. Journal of Veterinary Science, 5, 295-302. https://doi.org/10.4142/jvs.2004.5.4.295
Perello, M., Sakata, I., Birnbaum, S., Chuang, J.-C., Osborne-Lawrence, S., Rovinsky, S. A., Woloszyn, J., Yanagisawa, M., Lutter, M., & Zigman, J. M. (2010). Ghrelin increases the rewarding value of high-fat diet in an orexin-dependent manner. Biological Psychiatry, 67, 880-886. https://doi.org/10.1016/j.biopsych.2009.10.030
Petrovich, G. D., Hobin, M. P., & Reppucci, C. J. (2012). Selective Fos induction in hypothalamic orexin/hypocretin, but not melanin-concentrating hormone neurons, by a learned food-cue that stimulates feeding in sated rats. Neuroscience, 224, 70-80. https://doi.org/10.1016/j.neuroscience.2012.08.036
Peyron, C., Tighe, D. K., van den Pol, A. N., de Lecea, L., Heller, H. C., Sutcliffe, J. G., & Kilduff, T. S. (1998). Neurons containing hypocretin (orexin) project to multiple neuronal systems. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 18, 9996-10015. https://doi.org/10.1523/JNEUROSCI.18-23-09996.1998
Piccoli, L., Micioni Di Bonaventura, M. V., Cifani, C., Costantini, V. J. A., Massagrande, M., Montanari, D., Martinelli, P., Antolini, M., Ciccocioppo, R., Massi, M., Merlo-Pich, E., Di Fabio, R., & Corsi, M. (2012). Role of orexin-1 receptor mechanisms on compulsive food consumption in a model of binge eating in female rats. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology, 37, 1999-2011. https://doi.org/10.1038/npp.2012.48
Prud'homme, M. J., Lacroix, M. C., Badonnel, K., Gougis, S., Baly, C., Salesse, R., & Caillol, M. (2009). Nutritional status modulates behavioural and olfactory bulb Fos responses to isoamyl acetate or food odour in rats: Roles of orexins and leptin. Neuroscience, 162, 1287-1298. https://doi.org/10.1016/j.neuroscience.2009.05.043
Rashmi, K. S., Mayannavar, S., Deshpande, K., & Ganaraja, B. (2015). Involvement of neuropeptide Orexin B in basolateral amygdala mediated consummatory behaviour in male Wistar Albino rats. Indian Journal of Physiology and Pharmacology, 59, 175-181.
Richards, J. K., Simms, J. A., Steensland, P., Taha, S. A., Borgland, S. L., Bonci, A., & Bartlett, S. E. (2008). Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long-Evans rats. Psychopharmacology (Berl), 199, 109-117. https://doi.org/10.1007/s00213-008-1136-5
Rodgers, R. J., Halford, J. C. G., Nunes De Souza, R. L. et al (2001). SB-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-A in rats. European Journal of Neuroscience, 13, 1444-1452.
Rodgers, R. J., Halford, J. C. G., Nunes de Souza, R. L., Canto de Souza, A. L., Piper, D. C., Arch, J. R. S., & Blundell, J. E. (2000). Dose-response effects of orexin-A on food intake and the behavioural satiety sequence in rats. Regulatory Peptides, 96, 71-84. https://doi.org/10.1016/S0167-0115(00)00203-2
Rorabaugh, J. M., Stratford, J. M., & Zahniser, N. R. (2014). A relationship between reduced nucleus accumbens shell and enhanced lateral hypothalamic orexin neuronal activation in long-term fructose bingeing behavior. PLoS One, 9, e95019. https://doi.org/10.1371/journal.pone.0095019
Sabetghadam, A., Grabowiecka-Nowak, A., Kania, A., Gugula, A., Blasiak, E., Blasiak, T., Ma, S., Gundlach, A. L., & Blasiak, A. (2018). Melanin-concentrating hormone and orexin systems in rat nucleus incertus: Dual innervation, bidirectional effects on neuron activity, and differential influences on arousal and feeding. Neuropharmacology, 139, 238-256. https://doi.org/10.1016/j.neuropharm.2018.07.004
Sahu, A. (2002). Interactions of neuropeptide Y, hypocretin-I (orexin A) and melanin-concentrating hormone on feeding in rats. Brain Research, 944, 232-238. https://doi.org/10.1016/S0006-8993(02)02941-4
Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., Arch, J. R. S., Buckingham, R. E., Haynes, A. C., Carr, S. A., Annan, R. S., McNulty, D. E., Liu, W.-S., Terrett, J. A., Elshourbagy, N. A., … Yanagisawa, M. (1998). Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell, 92(4), 573-585. https://doi.org/10.1016/S0092-8674(00)80949-6
Sarihi, A., Emam, A. H., Panah, M. H., Komaki, A., Seif, S., Vafaeirad, M., & Alaii, E. (2015). Effects of activation and blockade of orexin A receptors in the medial preoptic area on food intake in male rats. Neuroscience Letters, 604, 157-160. https://doi.org/10.1016/j.neulet.2015.07.050
Semjonous, N. M., Smith, K. L., Parkinson, J. R. C., Gunner, D. J. L., Liu, Y. L., Murphy, K. G., Ghatei, M. A., Bloom, S. R., & Small, C. J. (2009). Coordinated changes in energy intake and expenditure following hypothalamic administration of neuropeptides involved in energy balance. International Journal of Obesity, 33, 775-785.
Sharf, R., Sarhan, M., Brayton, C. E., Guarnieri, D. J., Taylor, J. R., & DiLeone, R. J. (2010). Orexin signaling via the orexin 1 receptor mediates operant responding for food reinforcement. Biological Psychiatry, 67, 753-760. https://doi.org/10.1016/j.biopsych.2009.12.035
Sharf, R., Sarhan, M., & Dileone, R. J. (2010). Role of orexin/hypocretin in dependence and addiction. Brain Research, 1314, 130-138. https://doi.org/10.1016/j.brainres.2009.08.028
Shiraishi, T., Oomura, Y., Sasaki, K., & Wayner, M. J. (2000). Effects of leptin and orexin-A on food intake and feeding related hypothalamic neurons. Physiology and Behavior, 71, 251-261. https://doi.org/10.1016/S0031-9384(00)00341-3
Shoblock, J. R., Welty, N., Aluisio, L., Fraser, I., Motley, S. T., Morton, K., Palmer, J., Bonaventure, P., Carruthers, N. I., Lovenberg, T. W., Boggs, J., & Galici, R. (2011). Selective blockade of the orexin-2 receptor attenuates ethanol self-administration, place preference, and reinstatement. Psychopharmacology (Berl), 215, 191-203. https://doi.org/10.1007/s00213-010-2127-x
Steiner, M. A., Sciarretta, C., Pasquali, A., & Jenck, F. (2013). The selective orexin receptor 1 antagonist ACT-335827 in a rat model of diet-induced obesity associated with metabolic syndrome. Frontiers in Pharmacology, 4, 165. https://doi.org/10.3389/fphar.2013.00165
Sweet, D. C., Levine, A. S., Billington, C. J., & Kotz, C. M. (1999). Feeding response to central orexins. Brain Research, 821, 535-538. https://doi.org/10.1016/S0006-8993(99)01136-1
Sweet, D. C., Levine, A. S., & Kotz, C. M. (2004). Functional opioid pathways are necessary for hypocretin-1 (orexin-A)-induced feeding. Peptides, 25, 307-314. https://doi.org/10.1016/j.peptides.2003.12.014
Takano, S., Kanai, S., Hosoya, H., Ohta, M., Uematsu, H., & Miyasaka, K. (2004). Orexin-A does not stimulate food intake in old rats. American Journal of Physiology-Gastrointestinal and Liver Physiology, 287, G1182-1187. https://doi.org/10.1152/ajpgi.00218.2004
Terrill, S. J., Hyde, K. M., Kay, K. E., Greene, H. E., Maske, C. B., Knierim, A. E., Davis, J. F., & Williams, D. L. (2016). Ventral tegmental area orexin 1 receptors promote palatable food intake and oppose postingestive negative feedback. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 311, R592-599. https://doi.org/10.1152/ajpregu.00097.2016
Thompson, J. L., & Borgland, S. L. (2011). A role for hypocretin/orexin in motivation. Behavioural Brain Research, 217, 446-453. https://doi.org/10.1016/j.bbr.2010.09.028
Thorpe, A. J., Cleary, J. P., Levine, A. S., & Kotz, C. M. (2005). Centrally administered orexin A increases motivation for sweet pellets in rats. Psychopharmacology (Berl), 182, 75-83. https://doi.org/10.1007/s00213-005-0040-5
Thorpe, A. J., Doane, D. F., Sweet, D. C., Beverly, J. L., & Kotz, C. M. (2006). Orexin A in the rostrolateral hypothalamic area induces feeding by modulating GABAergic transmission. Brain Research, 1125, 60-66. https://doi.org/10.1016/j.brainres.2006.09.075
Thorpe, A. J., & Kotz, C. M. (2005). Orexin A in the nucleus accumbens stimulates feeding and locomotor activity. Brain Research, 1050, 156-162. https://doi.org/10.1016/j.brainres.2005.05.045
Thorpe, A. J., Mullett, M. A., Wang, C. F., & Kotz, C. M. (2003). Peptides that regulate food intake - Regional, metabolic, and circadian specificity of lateral hypothalamic orexin A feeding stimulation. The American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 284, R1409-R1417.
Thorpe, A. J., Teske, J. A., & Kotz, C. M. (2005). Orexin A-induced feeding is augmented by caloric challenge. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 289, R367-r372. https://doi.org/10.1152/ajpregu.00737.2004
Trivedi, P., Yu, H., MacNeil, D. J., Van der Ploeg, L. H. T., & Guan, X. M. (1998). Distribution of orexin receptor mRNA in the rat brain. FEBS Letters, 438, 71-75. https://doi.org/10.1016/S0014-5793(98)01266-6
Tsuji, T., Yamamoto, T., Tanaka, S., Bakhshishayan, S., & Kogo, M. (2011). Analyses of the facilitatory effect of orexin on eating and masticatory muscle activity in rats. Journal of Neurophysiology, 106, 3129-3135. https://doi.org/10.1152/jn.01108.2010
Valdivia, S., Patrone, A., Reynaldo, M., & Perello, M. (2014). Acute high fat diet consumption activates the mesolimbic circuit and requires orexin signaling in a mouse model. PLoS One, 9, e87478. https://doi.org/10.1371/journal.pone.0087478
Vickers, S. P., Hackett, D., Murray, F., Hutson, P. H., & Heal, D. J. (2015). Effects of lisdexamfetamine in a rat model of binge-eating. Journal of Psychopharmacology (Oxford, England), 29, 1290-1307. https://doi.org/10.1177/0269881115615107
Wang, C. F., & Kotz, C. M. (2002). Urocortin in the lateral septal area modulates feeding induced by orexin A in the lateral hypothalamus. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 283, R358-R367. https://doi.org/10.1152/ajpregu.00558.2001
Wang, M., Sun, X. R., Guo, F. F., Luan, X., Wang, C., & Xu, L. (2018). Activation of orexin-1 receptors in the amygdala enhances feeding in the diet-induced obesity rats: Blockade with mu-opioid antagonist. Biochemical and Biophysical Research Communications, 503, 3186-3191.
White, C. L., Ishii, Y., Mendoza, T., Upton, N., Stasi, L. P., Bray, G. A., & York, D. A. (2005). Effect of a selective OX1R antagonist on food intake and body weight in two strains of rats that differ in susceptibility to dietary-induced obesity. Peptides, 26, 2331-2338. https://doi.org/10.1016/j.peptides.2005.03.042
Williams, D. L., Coiduras, I. I., Parise, E. M., & Maske, C. B. (2020). Hindbrain orexin 1 receptors blunt intake suppression by gastrointestinal nutrients and cholecystokinin in male rats. Peptides, 133, 170351. https://doi.org/10.1016/j.peptides.2020.170351
Xu, T. R., Yang, Y., Ward, R., Gao, L. H., & Liu, Y. (2013). Orexin receptors: Multi-functional therapeutic targets for sleeping disorders, eating disorders, drug addiction, cancers and other physiological disorders. Cellular Signalling, 25, 2413-2423. https://doi.org/10.1016/j.cellsig.2013.07.025
Yamada, H., Okumura, T., Motomura, W., Kobayashi, Y., & Kohgo, Y. (2000). Inhibition of food intake by central injection of anti-orexin antibody in fasted rats. Biochemical and Biophysical Research Communications, 267, 527-531. https://doi.org/10.1006/bbrc.1999.1998
Yamanaka, A., Beuckmann, C. T., Willie, J. T., Hara, J., Tsujino, N., Mieda, M., Tominaga, M., Yagami, K.-I., Sugiyama, F., Goto, K., Yanagisawa, M., & Sakurai, T. (2003). Hypothalamic orexin neurons regulate arousal according to energy balance in mice. Neuron, 38, 701-713. https://doi.org/10.1016/S0896-6273(03)00331-3
Yamanaka, A., Kunii, K., Nambu, T., Tsujino, N., Sakai, A., Matsuzaki, I., Miwa, Y., Goto, K., & Sakurai, T. (2000). Orexin-induced food intake involves neuropeptide Y pathway. Brain Research, 859, 404-409. https://doi.org/10.1016/S0006-8993(00)02043-6
Yamanaka, A., Sakurai, T., Katsumoto, T., Yanagisawa, M., & Goto, K. (1999). Chronic intracerebroventricular administration of orexin-A to rats increases food intake in daytime, but has no effect on body weight. Brain Research, 849, 248-252. https://doi.org/10.1016/S0006-8993(99)01905-8
Yang, D. D., Xu, L., Guo, F. F., Sun, X. R., Zhang, D., & Wang, M. (2018). Orexin-A and endocannabinoid signaling regulate glucose-responsive arcuate nucleus neurons and feeding behavior in obese rats. Neuropeptides, 69, 26-38. https://doi.org/10.1016/j.npep.2018.04.001
Zheng, H. Y., & Berthoud, H. R. (2007). Eating for pleasure or calories. Current Opinion in Pharmacology, 7, 607-612.
Zheng, H., Patterson, L. M., & Berthoud, H. R. (2005). Orexin-A projections to the caudal medulla and orexin-induced c-Fos expression, food intake, and autonomic function. The Journal of Comparative Neurology, 485, 127-142. https://doi.org/10.1002/cne.20515
Zheng, H., Patterson, L. M., & Berthoud, H. R. (2007). Orexin signaling in the ventral tegmental area is required for high-fat appetite induced by opioid stimulation of the nucleus accumbens. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 27, 11075-11082. https://doi.org/10.1523/JNEUROSCI.3542-07.2007
Zink, A. N., Bunney, P. E., Holm, A. A., Billington, C. J., & Kotz, C. M. (2018). Neuromodulation of orexin neurons reduces diet-induced adiposity. International Journal of Obesity, 42, 737-745.