Quantifying the relationship and contribution of mitochondrial respiration to systemic exercise limitation in heart failure.
Exercise
HFrEF
Lactate threshold
Skeletal muscle
V̇O2peak
Journal
ESC heart failure
ISSN: 2055-5822
Titre abrégé: ESC Heart Fail
Pays: England
ID NLM: 101669191
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
revised:
12
01
2021
received:
30
10
2020
accepted:
04
02
2021
pubmed:
21
2
2021
medline:
2
7
2021
entrez:
20
2
2021
Statut:
ppublish
Résumé
Heart failure with reduced ejection fraction (HFrEF) induces skeletal muscle mitochondrial abnormalities that contribute to exercise limitation; however, specific mitochondrial therapeutic targets remain poorly established. This study quantified the relationship and contribution of distinct mitochondrial respiratory states to prognostic whole-body measures of exercise limitation in HFrEF. Male patients with HFrEF (n = 22) were prospectively enrolled and underwent ramp-incremental cycle ergometry cardiopulmonary exercise testing to determine exercise variables including peak pulmonary oxygen uptake (V̇O Mitochondrial respiratory states from skeletal muscle biopsies of patients with HFrEF were independently correlated to established non-invasive prognostic cycle ergometry cardiopulmonary exercise testing indices including V̇O
Identifiants
pubmed: 33609003
doi: 10.1002/ehf2.13272
pmc: PMC8006730
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
898-907Subventions
Organisme : British Heart Foundation
ID : FS/CRTF/20/24071
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S025472/1
Pays : United Kingdom
Organisme : British Heart Foundation
ID : PG/19/3/34133
Pays : United Kingdom
Informations de copyright
© 2021 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.
Références
Am J Cardiol. 1981 Jan;47(1):33-9
pubmed: 7457405
Circulation. 1992 May;85(5):1751-9
pubmed: 1315220
J Am Coll Cardiol. 1996 Jan;27(1):140-5
pubmed: 8522687
Heart. 2004 Oct;90(10):1144-50
pubmed: 15367509
J Physiol. 2003 Sep 1;551(Pt 2):491-501
pubmed: 12824444
J Am Heart Assoc. 2020 Sep 15;9(18):e017091
pubmed: 32892688
Clin Transplant. 2016 Feb;30(2):161-9
pubmed: 26589579
JAMA. 2009 Apr 8;301(14):1451-9
pubmed: 19351942
Circulation. 2016 Jun 14;133(24):e694-711
pubmed: 27143685
Europace. 2013 Jun;15(6):857-64
pubmed: 23322010
Med Sci Sports Exerc. 2020 Apr;52(4):810-819
pubmed: 31688648
Circulation. 2002 Dec 10;106(24):3079-84
pubmed: 12473555
Exp Physiol. 2007 Mar;92(2):347-55
pubmed: 17185348
Eur Heart J. 2013 Feb;34(7):512-9
pubmed: 23178647
J Appl Physiol (1985). 2015 Sep 15;119(6):739-44
pubmed: 25911681
J Card Fail. 2004 Apr;10(2):141-8
pubmed: 15101026
Circulation. 2019 Mar 12;139(11):1435-1450
pubmed: 30856000
J Am Coll Cardiol. 2016 Feb 23;67(7):780-9
pubmed: 26892413
J Am Coll Cardiol. 2017 Sep 26;70(13):1618-1636
pubmed: 28935040
Circulation. 2001 Jul 31;104(5):544-9
pubmed: 11479251
Respir Med. 2018 Feb;135:29-34
pubmed: 29414450
J Physiol. 2008 Jan 1;586(1):25-34
pubmed: 18006574
Med Sci Sports Exerc. 2000 Jan;32(1):70-84
pubmed: 10647532
J Am Coll Cardiol. 1997 Dec;30(7):1758-64
pubmed: 9385904
ESC Heart Fail. 2021 Apr;8(2):898-907
pubmed: 33609003
J Am Coll Cardiol. 1997 Apr;29(5):1067-73
pubmed: 9120161
Am J Cardiol. 2006 Aug 15;98(4):500-3
pubmed: 16893705
Eur J Prev Cardiol. 2020 Sep;27(13):1369-1385
pubmed: 31581819
Cochrane Database Syst Rev. 2004;(3):CD003331
pubmed: 15266480
J Cardiol. 2016 Nov;68(5):373-378
pubmed: 26867779
J Cachexia Sarcopenia Muscle. 2020 Apr;11(2):394-404
pubmed: 31863644
Med Sci Sports Exerc. 1993 Feb;25(2):191-6
pubmed: 8450720
Eur Heart J. 2002 Aug;23(16):1242-5
pubmed: 12175661
FASEB J. 2005 Jan;19(1):43-52
pubmed: 15629894
Eur J Heart Fail. 2016 Aug;18(8):891-975
pubmed: 27207191
J Cachexia Sarcopenia Muscle. 2020 Feb;11(1):79-88
pubmed: 31430834
Eur J Heart Fail. 2000 Mar;2(1):47-51
pubmed: 10742703
J Am Heart Assoc. 2018 Mar 27;7(7):
pubmed: 29588313
Circulation. 2000 Oct 10;102(15):1847-53
pubmed: 11023942
J Am Heart Assoc. 2019 Feb 19;8(4):e010554
pubmed: 30755074
Eur Heart J. 2002 May;23(10):806-14
pubmed: 12009721
Am J Cardiol. 1979 May;43(5):1009-14
pubmed: 433762
ESC Heart Fail. 2018 Apr;5(2):222-232
pubmed: 29235244
Circulation. 2018 Jan 9;137(2):148-161
pubmed: 28993402
J Appl Physiol (1985). 1986 Jun;60(6):2020-7
pubmed: 3087938
Circulation. 2016 Dec 13;134(24):e653-e699
pubmed: 27881567
Am J Physiol Heart Circ Physiol. 2012 Mar 1;302(5):H1050-63
pubmed: 22101528
Int J Cardiol. 1988 Feb;18(2):187-95
pubmed: 2830194
Eur Heart J. 1997 Jun;18(6):971-80
pubmed: 9183589
Science. 2005 Jan 21;307(5708):418-20
pubmed: 15662013
Expert Rev Respir Med. 2010 Apr;4(2):179-88
pubmed: 20406084
Respir Physiol. 1990 May-Jun;80(2-3):113-27
pubmed: 2218094
Methods Mol Biol. 2012;810:25-58
pubmed: 22057559