Cystathionine-gamma-lyase overexpression in T cells enhances antitumor effect independently of cysteine autonomy.
Adoptive Transfer
/ methods
Animals
CD8-Positive T-Lymphocytes
/ metabolism
Cell Engineering
Cell Line, Tumor
Cell Proliferation
Cystathionine gamma-Lyase
/ metabolism
Cysteine
/ biosynthesis
Extracellular Fluid
/ metabolism
Female
Glycine
/ metabolism
Methionine
/ metabolism
Mice
Mice, Inbred C57BL
Models, Animal
Ovarian Neoplasms
/ therapy
Proline
/ metabolism
Serine
/ metabolism
Tumor Microenvironment
/ immunology
T cell
adoptive cell transfer
amino acid
cysteine
metabolism
Journal
Cancer science
ISSN: 1349-7006
Titre abrégé: Cancer Sci
Pays: England
ID NLM: 101168776
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
revised:
05
02
2021
received:
26
06
2020
accepted:
14
02
2021
pubmed:
21
2
2021
medline:
11
5
2021
entrez:
20
2
2021
Statut:
ppublish
Résumé
T cells could be engineered to overcome the aberrant metabolic milieu of solid tumors and tip the balance in favor of a long-lasting clinical response. Here, we explored the therapeutic potential of stably overexpressing cystathionine-gamma-lyase (CTH, CSE, or cystathionase), a pivotal enzyme of the transsulfuration pathway, in antitumor CD8
Identifiants
pubmed: 33609296
doi: 10.1111/cas.14862
pmc: PMC8088958
doi:
Substances chimiques
Serine
452VLY9402
Proline
9DLQ4CIU6V
Methionine
AE28F7PNPL
Cystathionine gamma-Lyase
EC 4.4.1.1
Cysteine
K848JZ4886
Glycine
TE7660XO1C
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1723-1734Subventions
Organisme : Agence Nationale de la Recherche
ID : ANR-11-LABX-0016-01
Organisme : Fondation pour la Recherche Médicale
ID : ECO20160736078
Informations de copyright
© 2021 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.
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