Evaluation of a nanoflow interface based on the triple-tube coaxial sheath-flow sprayer for capillary electrophoresis-mass spectrometry coupling in metabolomics.

Amino Acids / blood Electrophoresis, Capillary / instrumentation Metabolomics / instrumentation Nanotechnology / instrumentation Reference Standards Signal Processing, Computer-Assisted
Amino acids CE-ESI-MS Capillary electrophoresis Mass spectrometry Nanoflow interface

Journal

Journal of chromatography. A
ISSN: 1873-3778
Titre abrégé: J Chromatogr A
Pays: Netherlands
ID NLM: 9318488

Informations de publication

Date de publication:
29 Mar 2021
Historique:
received: 21 12 2020
revised: 03 02 2021
accepted: 07 02 2021
pubmed: 22 2 2021
medline: 7 4 2021
entrez: 21 2 2021
Statut: ppublish

Résumé

The performance of an original CE-MS interface that allows the in-axis positioning of the electrospray with respect to the MS inlet was evaluated. The variations in the geometrical alignment of this configuration in the absence of a nebulizing gas afforded a significant reduction in the sheath-liquid flow rate from 3 µL/min to as low as 300 nL/min. The sheath liquid and BGE were respectively composed of H

Identifiants

DOI: 10.1016/j.chroma.2021.461982 PMID: 33611118
pubmed: 33611118
pii: S0021-9673(21)00106-0
doi: 10.1016/j.chroma.2021.461982
pii:
doi:

Substances chimiques

Amino Acids 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

461982

Informations de copyright

Copyright © 2021. Published by Elsevier B.V.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Sabrina Ferré (S)

School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland.

Nicolas Drouin (N)

School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland.

Víctor González-Ruiz (V)

School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland; Swiss Centre for Applied Human Toxicology (SCAHT), Switzerland.

Serge Rudaz (S)

School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland; Swiss Centre for Applied Human Toxicology (SCAHT), Switzerland. Electronic address: serge.rudaz@unige.ch.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Evaluation of a nanoflow interface based on...
questionsmedicales.fr › Techniques d'investigation › Techniques électrochimiques › Électrophorèse › Électrophorèse capillaire › Evaluation of a nanoflow interface based on...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Métabolomique › Evaluation of a nanoflow interface based on...
questionsmedicales.fr › Technologie, industrie et agriculture › Technologie › Miniaturisation › Nanotechnologie › Evaluation of a nanoflow interface based on...
questionsmedicales.fr › Techniques d'investigation › Poids et mesures › Normes de référence › Evaluation of a nanoflow interface based on...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Traitement du signal assisté par ordinateur › Evaluation of a nanoflow interface based on...