Cancer-Associated Fibroblasts Play an Important Role in Early-Stage Mycosis Fungoides.
Journal
The Journal of investigative dermatology
ISSN: 1523-1747
Titre abrégé: J Invest Dermatol
Pays: United States
ID NLM: 0426720
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
28
07
2020
revised:
07
08
2020
accepted:
07
08
2020
entrez:
23
2
2021
pubmed:
24
2
2021
medline:
25
9
2021
Statut:
ppublish
Résumé
Research in cutaneous T-cell lymphoma has widened from the malignant T cell itself to the tumor microenvironment. In this issue of the Journal of Investigative Dermatology, Aronovich et al. (2020) report the presence of cancer-associated fibroblasts (CAFs) in mycosis fungoides (MFs). They show that CAFs are abundant in early-stage MF and that they differ from normal fibroblasts. Moreover, CAFs are described to promote MF by increasing the motility and chemoresistance of malignant T cells. Thus, targeting CAFs in MF may be of therapeutic value.
Identifiants
pubmed: 33618804
pii: S0022-202X(20)31986-2
doi: 10.1016/j.jid.2020.08.006
pii:
doi:
Types de publication
Journal Article
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
479-480Commentaires et corrections
Type : CommentOn
Informations de copyright
Copyright © 2021 The Author. Published by Elsevier Inc. All rights reserved.