An increase in dendritic plateau potentials is associated with experience-dependent cortical map reorganization.


Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
02 03 2021
Historique:
entrez: 23 2 2021
pubmed: 24 2 2021
medline: 5 8 2021
Statut: ppublish

Résumé

The organization of sensory maps in the cerebral cortex depends on experience, which drives homeostatic and long-term synaptic plasticity of cortico-cortical circuits. In the mouse primary somatosensory cortex (S1) afferents from the higher-order, posterior medial thalamic nucleus (POm) gate synaptic plasticity in layer (L) 2/3 pyramidal neurons via disinhibition and the production of dendritic plateau potentials. Here we address whether these thalamocortically mediated responses play a role in whisker map plasticity in S1. We find that trimming all but two whiskers causes a partial fusion of the representations of the two spared whiskers, concomitantly with an increase in the occurrence of POm-driven

Identifiants

pubmed: 33619110
pii: 2024920118
doi: 10.1073/pnas.2024920118
pmc: PMC7936269
pii:
doi:

Substances chimiques

Excitatory Amino Acid Antagonists 0
GABA Antagonists 0
Receptors, GABA-A 0
Receptors, N-Methyl-D-Aspartate 0
Picrotoxin 124-87-8
Dizocilpine Maleate 6LR8C1B66Q

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2021 the Author(s). Published by PNAS.

Déclaration de conflit d'intérêts

The authors declare no competing interest.

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Auteurs

Stéphane Pagès (S)

Department of Basic Neurosciences and the Center for Neuroscience, Centre Médical Universitaire (CMU), University of Geneva, 1211 Geneva, Switzerland.

Nicolas Chenouard (N)

University of Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, UMR 5297, F-33000 Bordeaux, France.

Ronan Chéreau (R)

Department of Basic Neurosciences and the Center for Neuroscience, Centre Médical Universitaire (CMU), University of Geneva, 1211 Geneva, Switzerland.

Vladimir Kouskoff (V)

University of Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, UMR 5297, F-33000 Bordeaux, France.

Frédéric Gambino (F)

University of Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, UMR 5297, F-33000 Bordeaux, France frederic.gambino@u-bordeaux.fr anthony.holtmaat@unige.ch.

Anthony Holtmaat (A)

Department of Basic Neurosciences and the Center for Neuroscience, Centre Médical Universitaire (CMU), University of Geneva, 1211 Geneva, Switzerland; frederic.gambino@u-bordeaux.fr anthony.holtmaat@unige.ch.

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Classifications MeSH