COVA1-18 neutralizing antibody protects against SARS-CoV-2 in three preclinical models.

Journal

Research square
Titre abrégé: Res Sq
Pays: United States
ID NLM: 101768035

Informations de publication

Date de publication:
15 Feb 2021
Historique:
entrez: 23 2 2021
pubmed: 24 2 2021
medline: 24 2 2021
Statut: epublish

Résumé

One year into the Coronavirus Disease 2019 (COVID-19) pandemic caused by Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), effective treatments are still needed

Identifiants

DOI: 10.21203/rs.3.rs-235272/v1 PMID: 33619476 PMC: PMC7899470
pubmed: 33619476
doi: 10.21203/rs.3.rs-235272/v1
pmc: PMC7899470
pii:
doi:

Types de publication

Preprint

Langues

eng

Commentaires et corrections

Type : UpdateIn

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Auteurs

P Maisonnasse (P)

Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, Paris, France.

Y Aldon (Y)

Departments of Medical Microbiology of the Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105 AZ, Amsterdam, The Netherlands.

A Marc (A)

Université de Paris, INSERM, IAME, F-75018 Paris, France.

R Marlin (R)

Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, Paris, France.

N Dereuddre-Bosquet (N)

Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, Paris, France.

N A Kuzmina (NA)

Department of Pathology, University of Texas Medical Branch at Galveston, Texas, USA.
Galveston National Laboratory, Texas, USA.

A W Freyn (AW)

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York (NY), USA.

J L Snitselaar (JL)

Departments of Medical Microbiology of the Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105 AZ, Amsterdam, The Netherlands.

A Gonçalves (A)

Université de Paris, INSERM, IAME, F-75018 Paris, France.

T G Caniels (TG)

Departments of Medical Microbiology of the Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105 AZ, Amsterdam, The Netherlands.

J A Burger (JA)

Departments of Medical Microbiology of the Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105 AZ, Amsterdam, The Netherlands.

M Poniman (M)

Departments of Medical Microbiology of the Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105 AZ, Amsterdam, The Netherlands.

V Chesnais (V)

Life and Soft, 92350 Le Plessis-Robinson, France.

S Diry (S)

Life and Soft, 92350 Le Plessis-Robinson, France.

A Iershov (A)

Life and Soft, 92350 Le Plessis-Robinson, France.

A J Ronk (AJ)

Department of Pathology, University of Texas Medical Branch at Galveston, Texas, USA.
Galveston National Laboratory, Texas, USA.

S Jangra (S)

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York (NY), USA.

R Rathnasinghe (R)

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York (NY), USA.
Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York (NY), USA.

Pjm Brouwer (P)

Departments of Medical Microbiology of the Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105 AZ, Amsterdam, The Netherlands.

Tpl Bijl (T)

Departments of Medical Microbiology of the Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105 AZ, Amsterdam, The Netherlands.

J van Schooten (J)

Departments of Medical Microbiology of the Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105 AZ, Amsterdam, The Netherlands.

M Brinkkemper (M)

Departments of Medical Microbiology of the Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105 AZ, Amsterdam, The Netherlands.

H Liu (H)

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

M Yuan (M)

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

C E Mire (CE)

Galveston National Laboratory, Texas, USA.
Department of Microbiology, University of Texas Medical Branch at Galveston, Texas, USA.

M J van Breemen (MJ)

Departments of Medical Microbiology of the Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105 AZ, Amsterdam, The Netherlands.

V Contreras (V)

Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, Paris, France.

T Naninck (T)

Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, Paris, France.

J Lemaître (J)

Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, Paris, France.

N Kahlaoui (N)

Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, Paris, France.

F Relouzat (F)

Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, Paris, France.

C Chapon (C)

Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, Paris, France.

R Ho Tsong Fang (R)

Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, Paris, France.

C McDanal (C)

Duke Human Vaccine Institute & Department of Surgery, Durham, NC 27710, USA.

M Osei-Twum (M)

Nexelis, Laval, Québec, Canada.

N St-Amant (N)

Nexelis, Laval, Québec, Canada.

L Gagnon (L)

Nexelis, Laval, Québec, Canada.

D C Montefiori (DC)

Duke Human Vaccine Institute & Department of Surgery, Durham, NC 27710, USA.

I A Wilson (IA)

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

E Ginoux (E)

Life and Soft, 92350 Le Plessis-Robinson, France.

G J de Bree (GJ)

Internal Medicine of the Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105 AZ, Amsterdam, The Netherlands.

A García-Sastre (A)

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York (NY), USA.
Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York (NY), USA.
The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York (NY), USA.
Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York (NY), USA.

M Schotsaert (M)

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York (NY), USA.
Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York (NY), USA.

L Coughlan (L)

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York (NY), USA.
University of Maryland School of Medicine, Department of Microbiology and Immunology and Center for Vaccine Development and Global Health (CVD), 685 W. Baltimore Street, HSF1, Office #380E, Baltimore, MD 21201.

A Bukreyev (A)

Department of Pathology, University of Texas Medical Branch at Galveston, Texas, USA.
Galveston National Laboratory, Texas, USA.
Department of Microbiology, University of Texas Medical Branch at Galveston, Texas, USA.

S van der Werf (S)

Molecular Genetics of RNA Viruses, Department of Virology, Institut Pasteur, CNRS UMR 3569, Université de Paris, Paris, France.
National Reference Center for Respiratory Viruses, Institut Pasteur, Paris, France.

J Guedj (J)

Université de Paris, INSERM, IAME, F-75018 Paris, France.

R W Sanders (RW)

Departments of Medical Microbiology of the Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105 AZ, Amsterdam, The Netherlands.
Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA.

M J van Gils (MJ)

Departments of Medical Microbiology of the Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105 AZ, Amsterdam, The Netherlands.

R Le Grand (R)

Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, Paris, France.

Classifications MeSH