M Brinkkemper

Affiliations

Departments of Medical Microbiology of the Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105 AZ, Amsterdam, The Netherlands.

Publications (16)

A third SARS-CoV-2 spike vaccination improves neutralization of variants-of-concern.

NPJ vaccines

Avec: Mitch Brinkkemper , Philip J M Brouwer , Pauline Maisonnasse , Marloes Grobben , Tom G Caniels , Meliawati Poniman , Judith A Burger , Ilja Bontjer , Melissa Oomen , Joey H Bouhuijs , Cynthia A van der Linden , Julien Villaudy , Yme U van der Velden , Kwinten Sliepen , Marit J van Gils , Roger Le Grand , Rogier W Sanders

Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection.

Cell

Avec: Philip J M Brouwer , Mitch Brinkkemper , Pauline Maisonnasse , Nathalie Dereuddre-Bosquet , Marloes Grobben , Mathieu Claireaux , Marlon de Gast , Romain Marlin , Virginie Chesnais , Ségolène Diry , Joel D Allen , Yasunori Watanabe , Julia M Giezen , Gius Kerster , Hannah L Turner , Karlijn van der Straten , Cynthia A van der Linden , Yoann Aldon , Thibaut Naninck , Ilja Bontjer , Judith A Burger , Meliawati Poniman , Anna Z Mykytyn , Nisreen M A Okba , Edith E Schermer , Marielle J van Breemen , Rashmi Ravichandran , Tom G Caniels , Jelle van Schooten , Nidhal Kahlaoui , Vanessa Contreras , Julien Lemaître , Catherine Chapon , Raphaël Ho Tsong Fang , Julien Villaudy , Kwinten Sliepen , Yme U van der Velden , Bart L Haagmans , Godelieve J de Bree , Eric Ginoux , Andrew B Ward , Max Crispin , Neil P King , Sylvie van der Werf , Marit J van Gils , Roger Le Grand , Rogier W Sanders

Nanoparticle Vaccines for Inducing HIV-1 Neutralizing Antibodies.

Vaccines

Avec: Mitch Brinkkemper , Kwinten Sliepen

A spike virosome vaccine induces pan-sarbecovirus antibody responses in mice.

iScience

Avec: Mitch Brinkkemper , Meliawati Poniman , Esther Siteur-van Rijnstra , Widad Ait Iddouch , Tom P L Bijl , Denise Guerra , Khadija Tejjani , Marloes Grobben , Farien Bhoelan , Denzel Bemelman , Ronald Kempers , Marit J van Gils , Kwinten Sliepen , Toon Stegmann , Yme U van der Velden , Rogier W Sanders

COVA1-18 neutralizing antibody protects against SARS-CoV-2 in three preclinical models.

Nature communications

Avec: Pauline Maisonnasse , Yoann Aldon , Aurélien Marc , Romain Marlin , Nathalie Dereuddre-Bosquet , Natalia A Kuzmina , Alec W Freyn , Jonne L Snitselaar , Antonio Gonçalves , Tom G Caniels , Judith A Burger , Meliawati Poniman , Ilja Bontjer , Virginie Chesnais , Ségolène Diry , Anton Iershov , Adam J Ronk , Sonia Jangra , Raveen Rathnasinghe , Philip J M Brouwer , Tom P L Bijl , Jelle van Schooten , Mitch Brinkkemper , Hejun Liu , Meng Yuan , Chad E Mire , Mariëlle J van Breemen , Vanessa Contreras , Thibaut Naninck , Julien Lemaître , Nidhal Kahlaoui , Francis Relouzat , Catherine Chapon , Raphaël Ho Tsong Fang , Charlene McDanal , Mary Osei-Twum , Natalie St-Amant , Luc Gagnon , David C Montefiori , Ian A Wilson , Eric Ginoux , Godelieve J de Bree , Adolfo García-Sastre , Michael Schotsaert , Lynda Coughlan , Alexander Bukreyev , Sylvie van der Werf , Jérémie Guedj , Rogier W Sanders , Marit J van Gils , Roger Le Grand

SARS-CoV-2 infection activates dendritic cells via cytosolic receptors rather than extracellular TLRs.

European journal of immunology

Avec: Lieve E H van der Donk , Julia Eder , John L van Hamme , Philip J M Brouwer , Mitch Brinkkemper , Ad C van Nuenen , Marit J van Gils , Rogier W Sanders , Neeltje A Kootstra , Marta Bermejo-Jambrina , Teunis B H Geijtenbeek

A public antibody class recognizes an S2 epitope exposed on open conformations of SARS-CoV-2 spike.

Nature communications

Avec: Mathieu Claireaux , Tom G Caniels , Marlon de Gast , Julianna Han , Denise Guerra , Gius Kerster , Barbera D C van Schaik , Aldo Jongejan , Angela I Schriek , Marloes Grobben , Philip J M Brouwer , Karlijn van der Straten , Yoann Aldon , Joan Capella-Pujol , Jonne L Snitselaar , Wouter Olijhoek , Aafke Aartse , Mitch Brinkkemper , Ilja Bontjer , Judith A Burger , Meliawati Poniman , Tom P L Bijl , Jonathan L Torres , Jeffrey Copps , Isabel Cuella Martin , Steven W de Taeye , Godelieve J de Bree , Andrew B Ward , Kwinten Sliepen , Antoine H C van Kampen , Perry D Moerland , Rogier W Sanders , Marit J van Gils

Antigen- and scaffold-specific antibody responses to protein nanoparticle immunogens.

Cell reports. Medicine

Avec: John C Kraft , Minh N Pham , Laila Shehata , Mitch Brinkkemper , Seyhan Boyoglu-Barnum , Kaitlin R Sprouse , Alexandra C Walls , Suna Cheng , Mike Murphy , Deleah Pettie , Maggie Ahlrichs , Claire Sydeman , Max Johnson , Alyssa Blackstone , Daniel Ellis , Rashmi Ravichandran , Brooke Fiala , Samuel Wrenn , Marcos Miranda , Kwinten Sliepen , Philip J M Brouwer , Aleksandar Antanasijevic , David Veesler , Andrew B Ward , Masaru Kanekiyo , Marion Pepper , Rogier W Sanders , Neil P King

Broadening sarbecovirus neutralization with bispecific antibodies combining distinct conserved targets on the receptor binding domain.

Human vaccines & immunotherapeutics

Avec: Denise Guerra , Laura Radić , Mitch Brinkkemper , Meliawati Poniman , Lara van der Maas , Jonathan L Torres , Andrew B Ward , Kwinten Sliepen , Janke Schinkel , Rogier W Sanders , Marit J van Gils , Tim Beaumont

Mosaic and mixed HIV-1 glycoprotein nanoparticles elicit antibody responses to broadly neutralizing epitopes.

PLoS pathogens

Avec: Mitch Brinkkemper , Gius Kerster , Philip J M Brouwer , Andy S Tran , Jonathan L Torres , Roos A Ettema , Haye Nijhuis , Joel D Allen , Wenwen Zhu , Hongmei Gao , Wen-Hsin Lee , Tom P L Bijl , Jonne L Snitselaar , Judith A Burger , Ilja Bontjer , Wouter Olijhoek , Rashmi Ravichandran , Marielle J van Breemen , Iván Del Moral-Sánchez , Ronald Derking , Kwinten Sliepen , Gabriel Ozorowski , Max Crispin , David C Montefiori , Mathieu Claireaux , Andrew B Ward , Marit J van Gils , Neil P King , Rogier W Sanders

Cross-reactive antibodies after SARS-CoV-2 infection and vaccination.

eLife

Avec: Marloes Grobben , Karlijn van der Straten , Philip Jm Brouwer , Mitch Brinkkemper , Pauline Maisonnasse , Nathalie Dereuddre-Bosquet , Brent Appelman , Ah Ayesha Lavell , Lonneke A van Vught , Judith A Burger , Meliawati Poniman , Melissa Oomen , Dirk Eggink , Tom Pl Bijl , Hugo Dg van Willigen , Elke Wynberg , Bas J Verkaik , Orlane Ja Figaroa , Peter J de Vries , Tessel M Boertien , Auteur inconnu , Marije K Bomers , Jonne J Sikkens , Roger Le Grand , Menno D de Jong , Maria Prins , Amy W Chung , Godelieve J de Bree , Rogier W Sanders , Marit J van Gils

Probing Affinity, Avidity, Anticooperativity, and Competition in Antibody and Receptor Binding to the SARS-CoV-2 Spike by Single Particle Mass Analyses.

ACS central science

Avec: Victor Yin , Szu-Hsueh Lai , Tom G Caniels , Philip J M Brouwer , Mitch Brinkkemper , Yoann Aldon , Hejun Liu , Meng Yuan , Ian A Wilson , Rogier W Sanders , Marit J van Gils , Albert J R Heck

COVA1-18 neutralizing antibody protects against SARS-CoV-2 in three preclinical models.

Research square

Avec: P Maisonnasse , Y Aldon , A Marc , R Marlin , N Dereuddre-Bosquet , N A Kuzmina , A W Freyn , J L Snitselaar , A Gonçalves , T G Caniels , J A Burger , M Poniman , V Chesnais , S Diry , A Iershov , A J Ronk , S Jangra , R Rathnasinghe , Pjm Brouwer , Tpl Bijl , J van Schooten , M Brinkkemper , H Liu , M Yuan , C E Mire , M J van Breemen , V Contreras , T Naninck , J Lemaître , N Kahlaoui , F Relouzat , C Chapon , R Ho Tsong Fang , C McDanal , M Osei-Twum , N St-Amant , L Gagnon , D C Montefiori , I A Wilson , E Ginoux , G J de Bree , A García-Sastre , M Schotsaert , L Coughlan , A Bukreyev , S van der Werf , J Guedj , R W Sanders , M J van Gils , R Le Grand

Co-display of diverse spike proteins on nanoparticles broadens sarbecovirus neutralizing antibody responses.

iScience

Avec: Mitch Brinkkemper , Tim S Veth , Philip J M Brouwer , Hannah Turner , Meliawati Poniman , Judith A Burger , Joey H Bouhuijs , Wouter Olijhoek , Ilja Bontjer , Jonne L Snitselaar , Tom G Caniels , Cynthia A van der Linden , Rashmi Ravichandran , Julien Villaudy , Yme U van der Velden , Kwinten Sliepen , Marit J van Gils , Andrew B Ward , Neil P King , Albert J R Heck , Rogier W Sanders

Bispecific antibodies combine breadth, potency, and avidity of parental antibodies to neutralize sarbecoviruses.

iScience

Avec: Laura Radić , Kwinten Sliepen , Victor Yin , Mitch Brinkkemper , Joan Capella-Pujol , Angela I Schriek , Jonathan L Torres , Sandhya Bangaru , Judith A Burger , Meliawati Poniman , Ilja Bontjer , Joey H Bouhuijs , David Gideonse , Dirk Eggink , Andrew B Ward , Albert J R Heck , Marit J Van Gils , Rogier W Sanders , Janke Schinkel

Triple tandem trimer immunogens for HIV-1 and influenza nucleic acid-based vaccines.

NPJ vaccines

Avec: Iván Del Moral-Sánchez , Edmund G Wee , Yuejiao Xian , Wen-Hsin Lee , Joel D Allen , Alba Torrents de la Peña , Rebeca Fróes Rocha , James Ferguson , André N León , Sylvie Koekkoek , Edith E Schermer , Judith A Burger , Sanjeev Kumar , Robby Zwolsman , Mitch Brinkkemper , Aafke Aartse , Dirk Eggink , Julianna Han , Meng Yuan , Max Crispin , Gabriel Ozorowski , Andrew B Ward , Ian A Wilson , Tomáš Hanke , Kwinten Sliepen , Rogier W Sanders

Réseau de co-auteurs

Mitch Brinkkemper 15 collaborations

Rogier W Sanders 14 collaborations

Kwinten Sliepen 11 collaborations

Marit J van Gils 11 collaborations

Philip J M Brouwer 9 collaborations

Meliawati Poniman 9 collaborations

Judith A Burger 9 collaborations

Andrew B Ward 8 collaborations

Ilja Bontjer 7 collaborations

Tom G Caniels 6 collaborations

Marloes Grobben 5 collaborations

Pauline Maisonnasse 4 collaborations

Yme U van der Velden 4 collaborations

Roger Le Grand 4 collaborations

Yoann Aldon 4 collaborations

Rashmi Ravichandran 4 collaborations

Godelieve J de Bree 4 collaborations

Neil P King 4 collaborations

Tom P L Bijl 4 collaborations

Jonne L Snitselaar 4 collaborations

Jonathan L Torres 4 collaborations

Joey H Bouhuijs 3 collaborations

Cynthia A van der Linden 3 collaborations

Julien Villaudy 3 collaborations

Nathalie Dereuddre-Bosquet 3 collaborations

Mathieu Claireaux 3 collaborations

Joel D Allen 3 collaborations

Gius Kerster 3 collaborations

Karlijn van der Straten 3 collaborations

Max Crispin 3 collaborations

Denise Guerra 3 collaborations

Meng Yuan 3 collaborations

Ian A Wilson 3 collaborations

Wouter Olijhoek 3 collaborations

Dirk Eggink 3 collaborations

Albert J R Heck 3 collaborations

Melissa Oomen 2 collaborations

Marlon de Gast 2 collaborations

Romain Marlin 2 collaborations

Virginie Chesnais 2 collaborations

Ségolène Diry 2 collaborations

Thibaut Naninck 2 collaborations

Edith E Schermer 2 collaborations

Marielle J van Breemen 2 collaborations

Jelle van Schooten 2 collaborations

Nidhal Kahlaoui 2 collaborations

Vanessa Contreras 2 collaborations

Julien Lemaître 2 collaborations

Catherine Chapon 2 collaborations

Raphaël Ho Tsong Fang 2 collaborations

Eric Ginoux 2 collaborations

Sylvie van der Werf 2 collaborations

Hejun Liu 2 collaborations

David C Montefiori 2 collaborations

Julianna Han 2 collaborations

Angela I Schriek 2 collaborations

Joan Capella-Pujol 2 collaborations

Aafke Aartse 2 collaborations

Laura Radić 2 collaborations

Janke Schinkel 2 collaborations

Wen-Hsin Lee 2 collaborations

Iván Del Moral-Sánchez 2 collaborations

Gabriel Ozorowski 2 collaborations

Victor Yin 2 collaborations

Yasunori Watanabe 1 collaboration

Julia M Giezen 1 collaboration

Hannah L Turner 1 collaboration

Anna Z Mykytyn 1 collaboration

Nisreen M A Okba 1 collaboration

Bart L Haagmans 1 collaboration

Esther Siteur-van Rijnstra 1 collaboration

Widad Ait Iddouch 1 collaboration

Khadija Tejjani 1 collaboration

Farien Bhoelan 1 collaboration

Denzel Bemelman 1 collaboration

Ronald Kempers 1 collaboration

Toon Stegmann 1 collaboration

Aurélien Marc 1 collaboration

Natalia A Kuzmina 1 collaboration

Alec W Freyn 1 collaboration

Antonio Gonçalves 1 collaboration

Anton Iershov 1 collaboration

Adam J Ronk 1 collaboration

Sonia Jangra 1 collaboration

Raveen Rathnasinghe 1 collaboration

Chad E Mire 1 collaboration

Mariëlle J van Breemen 1 collaboration

Francis Relouzat 1 collaboration

Charlene McDanal 1 collaboration

Mary Osei-Twum 1 collaboration

Natalie St-Amant 1 collaboration

Luc Gagnon 1 collaboration

Adolfo García-Sastre 1 collaboration

Michael Schotsaert 1 collaboration

Lynda Coughlan 1 collaboration

Alexander Bukreyev 1 collaboration

Jérémie Guedj 1 collaboration

Lieve E H van der Donk 1 collaboration

Julia Eder 1 collaboration

John L van Hamme 1 collaboration

Ad C van Nuenen 1 collaboration

Neeltje A Kootstra 1 collaboration

Marta Bermejo-Jambrina 1 collaboration

Teunis B H Geijtenbeek 1 collaboration

Barbera D C van Schaik 1 collaboration

Aldo Jongejan 1 collaboration

Jeffrey Copps 1 collaboration

Isabel Cuella Martin 1 collaboration

Steven W de Taeye 1 collaboration

Antoine H C van Kampen 1 collaboration

Perry D Moerland 1 collaboration

John C Kraft 1 collaboration

Minh N Pham 1 collaboration

Laila Shehata 1 collaboration

Seyhan Boyoglu-Barnum 1 collaboration

Kaitlin R Sprouse 1 collaboration

Alexandra C Walls 1 collaboration

Suna Cheng 1 collaboration

Mike Murphy 1 collaboration

Deleah Pettie 1 collaboration

Maggie Ahlrichs 1 collaboration

Claire Sydeman 1 collaboration

Max Johnson 1 collaboration

Alyssa Blackstone 1 collaboration

Daniel Ellis 1 collaboration

Brooke Fiala 1 collaboration

Samuel Wrenn 1 collaboration

Marcos Miranda 1 collaboration

Aleksandar Antanasijevic 1 collaboration

David Veesler 1 collaboration

Masaru Kanekiyo 1 collaboration

Marion Pepper 1 collaboration

Lara van der Maas 1 collaboration

Tim Beaumont 1 collaboration

Andy S Tran 1 collaboration

Roos A Ettema 1 collaboration

Haye Nijhuis 1 collaboration

Wenwen Zhu 1 collaboration

Hongmei Gao 1 collaboration

Ronald Derking 1 collaboration

Philip Jm Brouwer 1 collaboration

Brent Appelman 1 collaboration

Ah Ayesha Lavell 1 collaboration

Lonneke A van Vught 1 collaboration

Tom Pl Bijl 1 collaboration

Hugo Dg van Willigen 1 collaboration

Elke Wynberg 1 collaboration

Bas J Verkaik 1 collaboration

Orlane Ja Figaroa 1 collaboration

Peter J de Vries 1 collaboration

Tessel M Boertien 1 collaboration

None None 1 collaboration

Marije K Bomers 1 collaboration

Jonne J Sikkens 1 collaboration

Menno D de Jong 1 collaboration

Maria Prins 1 collaboration

Amy W Chung 1 collaboration

Szu-Hsueh Lai 1 collaboration

P Maisonnasse 1 collaboration

Y Aldon 1 collaboration

A Marc 1 collaboration

R Marlin 1 collaboration

N Dereuddre-Bosquet 1 collaboration

N A Kuzmina 1 collaboration

A W Freyn 1 collaboration

J L Snitselaar 1 collaboration

A Gonçalves 1 collaboration

T G Caniels 1 collaboration

J A Burger 1 collaboration

M Poniman 1 collaboration

V Chesnais 1 collaboration

S Diry 1 collaboration

A Iershov 1 collaboration

A J Ronk 1 collaboration

S Jangra 1 collaboration

R Rathnasinghe 1 collaboration

Pjm Brouwer 1 collaboration

Tpl Bijl 1 collaboration

J van Schooten 1 collaboration

H Liu 1 collaboration

M Yuan 1 collaboration

C E Mire 1 collaboration

M J van Breemen 1 collaboration

V Contreras 1 collaboration

T Naninck 1 collaboration

J Lemaître 1 collaboration

N Kahlaoui 1 collaboration

F Relouzat 1 collaboration

C Chapon 1 collaboration

R Ho Tsong Fang 1 collaboration

C McDanal 1 collaboration

M Osei-Twum 1 collaboration

N St-Amant 1 collaboration

L Gagnon 1 collaboration

D C Montefiori 1 collaboration

I A Wilson 1 collaboration

E Ginoux 1 collaboration

G J de Bree 1 collaboration

A García-Sastre 1 collaboration

M Schotsaert 1 collaboration

L Coughlan 1 collaboration

A Bukreyev 1 collaboration

S van der Werf 1 collaboration

J Guedj 1 collaboration

R W Sanders 1 collaboration

M J van Gils 1 collaboration

R Le Grand 1 collaboration

Tim S Veth 1 collaboration

Hannah Turner 1 collaboration

Sandhya Bangaru 1 collaboration

David Gideonse 1 collaboration

Marit J Van Gils 1 collaboration

Edmund G Wee 1 collaboration

Yuejiao Xian 1 collaboration

Alba Torrents de la Peña 1 collaboration

Rebeca Fróes Rocha 1 collaboration

James Ferguson 1 collaboration

André N León 1 collaboration

Sylvie Koekkoek 1 collaboration

Sanjeev Kumar 1 collaboration

Robby Zwolsman 1 collaboration

Tomáš Hanke 1 collaboration