Antiviral activity of different extracts of standardized propolis preparations against HSV.
Journal
Antiviral therapy
ISSN: 2040-2058
Titre abrégé: Antivir Ther
Pays: England
ID NLM: 9815705
Informations de publication
Date de publication:
2020
2020
Historique:
accepted:
04
02
2021
pubmed:
24
2
2021
medline:
7
5
2022
entrez:
23
2
2021
Statut:
ppublish
Résumé
Viral infections are among the most common problems in health-care practice. Natural products offer great promise as potentially effective antiviral drugs. Propolis is a honeybee product with biological properties and therapeutic applications. We aimed to investigate the antiviral activity of different extracts of Standardized Propolis Preparations (M.E.D.®) with glycol, ethanol, glycerol and soya oil, against herpes simplex type-1 (HSV-1) and type 2 (HSV-2) viruses. Chemical composition and antiviral activity of each extract were determined. The selective index (SI=CC SI values of glycol, ethanol, glycerol, soya oil extracts and acyclovir were determined as 6.8, 4.1, 2.2, 3.3 and 6.3 against HSV-1, and as 6.4, 7.7, 1.9, 4.2 and 2.9 against HSV-2, respectively. Glycolic propolis extract was found to possess a greater antiviral activity than acyclovir for both HSV-1 and 2, while glycolic, ethanolic and soya oil preparations were found to have more significant activity than acyclovir for HSV-2. It was determined that standardized propolis preparations have antiviral bioactivity against HSV.
Sections du résumé
BACKGROUND
Viral infections are among the most common problems in health-care practice. Natural products offer great promise as potentially effective antiviral drugs. Propolis is a honeybee product with biological properties and therapeutic applications. We aimed to investigate the antiviral activity of different extracts of Standardized Propolis Preparations (M.E.D.®) with glycol, ethanol, glycerol and soya oil, against herpes simplex type-1 (HSV-1) and type 2 (HSV-2) viruses.
METHODS
Chemical composition and antiviral activity of each extract were determined. The selective index (SI=CC
RESULTS
SI values of glycol, ethanol, glycerol, soya oil extracts and acyclovir were determined as 6.8, 4.1, 2.2, 3.3 and 6.3 against HSV-1, and as 6.4, 7.7, 1.9, 4.2 and 2.9 against HSV-2, respectively. Glycolic propolis extract was found to possess a greater antiviral activity than acyclovir for both HSV-1 and 2, while glycolic, ethanolic and soya oil preparations were found to have more significant activity than acyclovir for HSV-2.
CONCLUSIONS
It was determined that standardized propolis preparations have antiviral bioactivity against HSV.
Substances chimiques
Antiviral Agents
0
Glycols
0
Plant Extracts
0
Ethanol
3K9958V90M
Soybean Oil
8001-22-7
Propolis
9009-62-5
Glycerol
PDC6A3C0OX
Acyclovir
X4HES1O11F
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM