Adipose triglyceride lipase promotes the proliferation of colorectal cancer cells via enhancing the lipolytic pathway.
Animals
Apoptosis
Biomarkers, Tumor
/ genetics
Cell Proliferation
Colorectal Neoplasms
/ genetics
Female
Gene Expression Regulation, Neoplastic
Humans
Lipase
/ genetics
Lipid Metabolism
Lipolysis
Male
Mice
Mice, Inbred BALB C
Mice, Nude
Middle Aged
Prognosis
Survival Rate
Tumor Cells, Cultured
Xenograft Model Antitumor Assays
adipose triglyceride lipase
colorectal cancer
lipolytic
proliferation
Journal
Journal of cellular and molecular medicine
ISSN: 1582-4934
Titre abrégé: J Cell Mol Med
Pays: England
ID NLM: 101083777
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
revised:
04
01
2021
received:
11
08
2020
accepted:
28
01
2021
pubmed:
24
2
2021
medline:
23
9
2021
entrez:
23
2
2021
Statut:
ppublish
Résumé
Abnormal lipid metabolism is the sign of tumour cells. Previous researches have revealed that the lipolytic pathway may contribute to the progression of colorectal cancer (CRC). However, adipose triglyceride lipase (ATGL) role in CRC cells remains unclear. Here, we find that elevated ATGL positively correlates with CRC clinical stages and negatively associates with overall survival. Overexpression of ATGL significantly promotes CRC cell proliferation, while knockdown of ATGL inhibits the proliferation and promotes the apoptosis of CRC cells in vitro. Moreover, in vivo experiments, ATGL promotes the growth of CRC cells. Mechanistically, ATGL enhances the carcinogenic function of CRC cells via promoting sphingolipid metabolism and CoA biosynthesis pathway-related gene levels by degrading triglycerides, which provides adequate nutrition for the progression of CRC. Our researches clarify for the first time that ATGL is a novel oncogene in CRC and may provide an important prognostic factor and therapeutic target for CRC.
Identifiants
pubmed: 33621408
doi: 10.1111/jcmm.16349
pmc: PMC8051714
doi:
Substances chimiques
Biomarkers, Tumor
0
Lipase
EC 3.1.1.3
PNPLA2 protein, human
EC 3.1.1.3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3963-3975Subventions
Organisme : Natural Science Foundation of Guangdong Province
ID : 2018A030310298
Organisme : Guangzhou Institute of Pediatrics/Guangzhou Women and Children's Medical Center
ID : YIP-2019-021
Organisme : Educational Commission of Guangdong Province
ID : 2017KTSCX155
Organisme : Shenzhen Science and Technology Innovation Commission Basic Research Foundation
ID : JCYJ20180307150637015
Organisme : Guangdong Basic and Applied Basic Research Foundation
ID : 2019A1515011318
Organisme : National Nature Science Foundation of China
ID : 81902693
Informations de copyright
© 2021 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.
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