IgM paraprotein and anti-MAG sensory polyneuropathy associated with Waldenstrom's macroglobulinaemia and medullary carcinoma of the thyroid.
clinical neurophysiology
haematology (incl blood transfusion)
monoclonal gammopathy of undetermined significance associated neuropathy
peripheral nerve disease
thyroid disease
Journal
BMJ case reports
ISSN: 1757-790X
Titre abrégé: BMJ Case Rep
Pays: England
ID NLM: 101526291
Informations de publication
Date de publication:
23 Feb 2021
23 Feb 2021
Historique:
entrez:
24
2
2021
pubmed:
25
2
2021
medline:
15
5
2021
Statut:
epublish
Résumé
A previously fit and well 76-year-old man, presented with distal lower limb sensory symptoms suggestive of peripheral sensory neuropathy, associated with positive anti-MAG antibodies (myelin associated glycoprotein) and IgM paraprotein. Bone marrow biopsy showed lymphoplasmocytoid lymphoma (Waldenstrom's macroglobulinaemia, WM), consequently positive for MYD88 mutation. He subsequently developed medullary carcinoma of the thyroid, most likely secondary to WM. He underwent a successful total thyroidectomy and four treatment doses of rituximab, which proved beneficial. He is currently stable and under multidisciplinary monitoring. His sensory symptoms have improved following rituximab treatment and his WM is under control.
Identifiants
pubmed: 33622752
pii: 14/2/e240242
doi: 10.1136/bcr-2020-240242
pmc: PMC7907858
pii:
doi:
Substances chimiques
Immunoglobulin M
0
Myelin-Associated Glycoprotein
0
Paraproteins
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© BMJ Publishing Group Limited 2021. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
BMJ Case Rep. 2019 Mar 31;12(3):
pubmed: 30936346
Ann Neurol. 2009 Mar;65(3):286-93
pubmed: 19334068
Crit Rev Neurobiol. 1988;3(4):301-32
pubmed: 2458847
J Neurol. 1991 Oct;238(7):383-91
pubmed: 1660064
Curr Neurol Neurosci Rep. 2012 Feb;12(1):102-10
pubmed: 22090258
Rev Neurol Dis. 2008 Winter;5(1):14-22
pubmed: 18418318
Ann Oncol. 2012 Feb;23(2):411-5
pubmed: 21525403
Can J Neurol Sci. 2011 Mar;38(2):289-95
pubmed: 21320835
Cancer. 2015 Jul 1;121(13):2230-6
pubmed: 25757851
J Neurochem. 1982 Nov;39(5):1261-5
pubmed: 6181197
Cochrane Database Syst Rev. 2016 Oct 04;10:CD002827
pubmed: 27701752
J Immunol Res. 2015;2015:450391
pubmed: 26065001
J Neuroimmunol. 2014 Mar 15;268(1-2):89-94
pubmed: 24529728