Prolonged evolution of the human B cell response to SARS-CoV-2 infection.
Adult
Aged
Antibodies, Monoclonal
/ immunology
Antibodies, Neutralizing
/ immunology
Antibodies, Viral
/ immunology
B-Lymphocytes
/ immunology
Binding Sites
COVID-19
/ immunology
Cohort Studies
Cross Reactions
Female
Humans
Immunologic Memory
Longitudinal Studies
Male
Middle Aged
SARS-CoV-2
/ immunology
Journal
Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624
Informations de publication
Date de publication:
23 02 2021
23 02 2021
Historique:
received:
21
01
2021
accepted:
18
02
2021
entrez:
24
2
2021
pubmed:
25
2
2021
medline:
9
3
2021
Statut:
ppublish
Résumé
A comprehensive understanding of the kinetics and evolution of the human B cell response to SARS-CoV-2 infection will facilitate the development of next-generation vaccines and therapies. Here, we longitudinally profiled this response in mild and severe COVID-19 patients over a period of five months. Serum neutralizing antibody (nAb) responses waned rapidly but spike (S)-specific IgG
Identifiants
pubmed: 33622975
pii: 6/56/eabg6916
doi: 10.1126/sciimmunol.abg6916
pmc: PMC8128290
pii:
doi:
Substances chimiques
Antibodies, Monoclonal
0
Antibodies, Neutralizing
0
Antibodies, Viral
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI127521
Pays : United States
Informations de copyright
Copyright © 2021, American Association for the Advancement of Science.
Références
Cell Host Microbe. 2020 Sep 9;28(3):486-496.e6
pubmed: 32738193
Nature. 2020 Jul;583(7815):290-295
pubmed: 32422645
Nat Med. 2021 Apr;27(4):622-625
pubmed: 33654292
PLoS Pathog. 2021 Apr 8;17(4):e1009453
pubmed: 33831132
Annu Rev Immunol. 2017 Apr 26;35:255-284
pubmed: 28142324
Nature. 2021 Apr;592(7855):616-622
pubmed: 33567448
Methods Enzymol. 2002;350:87-96
pubmed: 12073338
Science. 2021 Feb 5;371(6529):
pubmed: 33408181
Cell. 2021 Mar 4;184(5):1201-1213.e14
pubmed: 33571429
Nature. 2019 Feb;566(7744):393-397
pubmed: 30664748
Emerg Infect Dis. 2020 Jun;26(6):1339-1441
pubmed: 32168463
Nature. 2020 Aug;584(7821):437-442
pubmed: 32555388
Science. 2020 Mar 13;367(6483):1260-1263
pubmed: 32075877
Science. 2020 Aug 28;369(6507):1119-1123
pubmed: 32661058
Nat Med. 2020 Sep;26(9):1422-1427
pubmed: 32651581
Cell. 2020 Jul 9;182(1):73-84.e16
pubmed: 32425270
Science. 2021 Feb 19;371(6531):823-829
pubmed: 33495307
Cell. 2019 May 30;177(6):1566-1582.e17
pubmed: 31104840
Cell Host Microbe. 2021 Mar 10;29(3):463-476.e6
pubmed: 33592168
Science. 2020 Aug 7;369(6504):731-736
pubmed: 32540900
Vaccine. 2000 Nov 22;19(7-8):877-85
pubmed: 11115711
Cell. 2021 Jan 7;184(1):169-183.e17
pubmed: 33296701
Cell. 2020 Oct 1;183(1):143-157.e13
pubmed: 32877699
Proc Natl Acad Sci U S A. 2021 Sep 7;118(36):
pubmed: 34417349
Science. 2020 Sep 18;369(6510):1501-1505
pubmed: 32703906
Front Immunol. 2021 Jan 28;11:618685
pubmed: 33584712
Science. 2020 Aug 21;369(6506):956-963
pubmed: 32540903
Cell Host Microbe. 2020 Sep 9;28(3):475-485.e5
pubmed: 32735849
Nat Microbiol. 2020 Apr;5(4):562-569
pubmed: 32094589
Immunity. 2020 Dec 15;53(6):1272-1280.e5
pubmed: 33242394
Nature. 2021 Mar;591(7851):639-644
pubmed: 33461210
Science. 2020 Dec 4;370(6521):1227-1230
pubmed: 33115920
Cell. 2021 Mar 4;184(5):1171-1187.e20
pubmed: 33621484
Nat Rev Immunol. 2014 Jul;14(7):495-504
pubmed: 24948364
Proc Natl Acad Sci U S A. 2020 Mar 24;117(12):6675-6685
pubmed: 32152119
Cell. 2020 Sep 3;182(5):1284-1294.e9
pubmed: 32730807
Nature. 2020 Dec;588(7839):682-687
pubmed: 33045718
Cell. 2020 Aug 20;182(4):828-842.e16
pubmed: 32645326
J Infect Dis. 2021 Feb 3;223(2):197-205
pubmed: 33535236