Cell-type-specific recruitment of GABAergic interneurons in the primary somatosensory cortex by long-range inputs.
Animals
Female
GABAergic Neurons
/ metabolism
Interneurons
/ metabolism
Male
Mice, Transgenic
Neural Inhibition
Neural Pathways
/ cytology
Neuroanatomical Tract-Tracing Techniques
Parvalbumins
/ metabolism
Pyramidal Cells
/ metabolism
Somatosensory Cortex
/ cytology
Synaptic Transmission
Vasoactive Intestinal Peptide
/ metabolism
Vibrissae
/ innervation
gamma-Aminobutyric Acid
/ metabolism
GABAergic interneurons
PV interneuron
SST interneurons
VIP interneuron
cortical circuits
cortical feedback
corticocortical interaction
disinhibition
feedforward inhibition
primary somatosensory cortex
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
23 02 2021
23 02 2021
Historique:
received:
08
04
2020
revised:
12
10
2020
accepted:
29
01
2021
entrez:
24
2
2021
pubmed:
25
2
2021
medline:
27
1
2022
Statut:
ppublish
Résumé
Extensive hierarchical yet highly reciprocal interactions among cortical areas are fundamental for information processing. However, connectivity rules governing the specificity of such corticocortical connections, and top-down feedback projections in particular, are poorly understood. We analyze synaptic strength from functionally relevant brain areas to diverse neuronal types in the primary somatosensory cortex (S1). Long-range projections from different areas preferentially engage specific sets of GABAergic neurons in S1. Projections from other somatosensory cortices strongly recruit parvalbumin (PV)-positive GABAergic neurons and lead to PV neuron-mediated feedforward inhibition of pyramidal neurons in S1. In contrast, inputs from whisker-related primary motor cortex are biased to vasoactive intestinal peptide (VIP)-positive GABAergic neurons and potentially result in VIP neuron-mediated disinhibition. Regardless of the input areas, somatostatin-positive neurons receive relatively weak long-range inputs. Computational analyses suggest that a characteristic combination of synaptic inputs to different GABAergic IN types in S1 represents a specific long-range input area.
Identifiants
pubmed: 33626343
pii: S2211-1247(21)00087-5
doi: 10.1016/j.celrep.2021.108774
pmc: PMC7995594
mid: NIHMS1677110
pii:
doi:
Substances chimiques
Parvalbumins
0
Vasoactive Intestinal Peptide
37221-79-7
gamma-Aminobutyric Acid
56-12-2
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
108774Subventions
Organisme : Intramural NIH HHS
ID : ZIA MH002959
Pays : United States
Informations de copyright
Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
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