Physcion, a novel inhibitor of 5α-reductase that promotes hair growth in vitro and in vivo.
5α-reductase
Androgenic alopecia
Hair
Physcion
Journal
Archives of dermatological research
ISSN: 1432-069X
Titre abrégé: Arch Dermatol Res
Pays: Germany
ID NLM: 8000462
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
received:
21
07
2020
accepted:
06
02
2021
revised:
16
11
2020
pubmed:
27
2
2021
medline:
22
3
2022
entrez:
26
2
2021
Statut:
ppublish
Résumé
Androgenic alopecia (AGA) has a high incidence. Excess dihydrotestosterone in blood capillaries, which is converted from testosterone by 5α-reductase, is an AGA causative factor. We identified the inhibitory activity of four Polygonum multiflorum compounds against 5α-reductase via high-performance liquid chromatography, and the results showed that Physcion was a potent 5α-reductase inhibitor. Additionally, we found that through inhibiting 5α-reductase expression, Physcion could shorten the time of dorsal skin darkening and hair growth, improve hair follicle morphology, and significantly increase hair follicle count. Eventually, through molecular docking study, we found the binding energy and molecular interactions between Physcion and 5α-reductase type II. These results suggested that Physcion is a potent 5α-reductase inhibitor, as well as a new natural medicine for treating AGA.
Identifiants
pubmed: 33635414
doi: 10.1007/s00403-021-02195-1
pii: 10.1007/s00403-021-02195-1
doi:
Substances chimiques
5-alpha Reductase Inhibitors
0
Plant Extracts
0
physcione
H6PT94IV61
Emodin
KA46RNI6HN
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
41-51Subventions
Organisme : Special Innovation Project of Guangdong Provincial Education Department
ID : 2018KTSCX036
Organisme : Science and Technology Planning Project of Nansha District, Guangdong Province
ID : 2016CX003
Organisme : Science and Technology Planning Project of Nansha District, Guangdong Province
ID : 2017CX005
Organisme : Science & Technology Planning Project of Guangdong Province Office of Education
ID : 2014GKXM032
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature.
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