Recrudescence of a high parasitaemia, severe Plasmodium falciparum malaria episode, treated by artesunate monotherapy.

Aged Antimalarials / therapeutic use Artesunate / therapeutic use Humans Malaria, Falciparum / drug therapy Male Parasitemia / drug therapy Recurrence
Artesunate K13 Parasite clearance time Resistance Severe malaria

Journal

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
ISSN: 1878-3511
Titre abrégé: Int J Infect Dis
Pays: Canada
ID NLM: 9610933

Informations de publication

Date de publication:
Apr 2021
Historique:
received: 03 02 2021
revised: 18 02 2021
accepted: 19 02 2021
pubmed: 27 2 2021
medline: 3 6 2021
entrez: 26 2 2021
Statut: ppublish

Résumé

A patient presenting with severe malaria, with hyperparasitaemia, received 7-day artesunate monotherapy. A severe recrudescence was detected and attributed to hyperparasitaemia, monotherapy and a polyclonal infection without Kelch 13 gene mutation. A second treatment with artesunate, then quinine, followed by artemether-lumefantrine, was successful.

Identifiants

DOI: 10.1016/j.ijid.2021.02.080 PMID: 33636354
pubmed: 33636354
pii: S1201-9712(21)00166-1
doi: 10.1016/j.ijid.2021.02.080
pii:
doi:

Substances chimiques

Antimalarials 0
Artesunate 60W3249T9M

Types de publication

Case Reports

Langues

eng

Sous-ensembles de citation

IM

Pagination

345-348

Informations de copyright

Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.

Auteurs

Sophie Landre (S)

Service des Maladies Infectieuses et Tropicales, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, 69004 Lyon, France.

Anne-Lise Bienvenu (AL)

Service Pharmacie, Groupement Hospitalier Nord, Hospices Civils de Lyon, 69004 Lyon, France.

Patrick Miailhes (P)

Service des Maladies Infectieuses et Tropicales, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, 69004 Lyon, France.

Paul Abraham (P)

Anesthesiology and Critical Care Medicine, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France.

Marie Simon (M)

Service de Médecine Intensive-Réanimation, Hôpital Edouard Herriot, Hospices Civils de Lyon, 69437 Lyon Cedex 03, France.

Agathe Becker (A)

Service des Maladies Infectieuses et Tropicales, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, 69004 Lyon, France.

Anne Conrad (A)

Service des Maladies Infectieuses et Tropicales, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, 69004 Lyon, France.

Guillaume Bonnot (G)

Univ Lyon, Malaria Research Unit, UMR 5246 CNRS-INSA-CPE-University Lyon1, 69100 Villeurbanne, France.

Yobouet Ines Kouakou (YI)

Univ Lyon, Malaria Research Unit, UMR 5246 CNRS-INSA-CPE-University Lyon1, 69100 Villeurbanne, France; Institute of Parasitology and Medical Mycology, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, 69004 Lyon, France.

Christian Chidiac (C)

Service des Maladies Infectieuses et Tropicales, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, 69004 Lyon, France.

Gilles Leboucher (G)

Service Pharmacie, Groupement Hospitalier Nord, Hospices Civils de Lyon, 69004 Lyon, France.

Thomas Rimmelé (T)

Anesthesiology and Critical Care Medicine, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France.

Laurent Argaud (L)

Service de Médecine Intensive-Réanimation, Hôpital Edouard Herriot, Hospices Civils de Lyon, 69437 Lyon Cedex 03, France.

Stephane Picot (S)

Univ Lyon, Malaria Research Unit, UMR 5246 CNRS-INSA-CPE-University Lyon1, 69100 Villeurbanne, France; Institute of Parasitology and Medical Mycology, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, 69004 Lyon, France. Electronic address: stephane.picot@univ-lyon1.fr.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Recrudescence of a high parasitaemia, severe...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiparasitaires › Antiprotozoaires › Antipaludiques › Recrudescence of a high parasitaemia, severe...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Sesquiterpènes › Artémisinines › Artésunate › Recrudescence of a high parasitaemia, severe...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Recrudescence of a high parasitaemia, severe...
questionsmedicales.fr › Infection › Maladies vectorielles › Paludisme › Paludisme à Plasmodium falciparum › Recrudescence of a high parasitaemia, severe...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Sepsie › Parasitémie › Recrudescence of a high parasitaemia, severe...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Récidive › Recrudescence of a high parasitaemia, severe...