CD1 and MR1 recognition by human γδ T cells.
CD1 glycoproteins
MHC-like molecules
MR1 molecule
γδ T cells
Journal
Molecular immunology
ISSN: 1872-9142
Titre abrégé: Mol Immunol
Pays: England
ID NLM: 7905289
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
received:
13
11
2020
accepted:
03
12
2020
pubmed:
27
2
2021
medline:
23
6
2021
entrez:
26
2
2021
Statut:
ppublish
Résumé
The two main T cell lineages, αβ and γδ T cells, play a central role in immunity. Unlike αβ T cells that recognize antigens bound to the Major Histocompatibility Complex (MHC) or MHC class I-like antigen-presenting molecules, the ligands for γδ T cell receptors (TCRs) are much more diverse. However, it is now clear that γδ TCRs can also recognize MHC class I-like molecules, including CD1b, CD1c, CD1d and the MHC class I-related protein 1 (MR1). Yet, our understanding at the molecular level of γδ T cell immunity to CD1 and MR1 is still very limited. Here, we discuss new molecular paradigms underpinning γδ TCRs recognition of antigens, antigen-presenting molecules or both. The recent discovery of recognition of MR1 by a γδ TCR at a position located underneath the antigen display platform reinforces the view that γδ TCRs can approach their ligands from many directions, unlike αβ TCRs that bind MHC, CD1 and MR1 targets in an aligned, end to end fashion.
Identifiants
pubmed: 33636434
pii: S0161-5890(20)30569-1
doi: 10.1016/j.molimm.2020.12.008
pmc: PMC8075093
mid: NIHMS1687695
pii:
doi:
Substances chimiques
Antigens, CD1
0
Antigens, CD1d
0
CD1C protein, human
0
CD1D protein, human
0
CD1b antigen
0
Glycoproteins
0
Histocompatibility Antigens Class I
0
MR1 protein, human
0
Minor Histocompatibility Antigens
0
Receptors, Antigen, T-Cell, gamma-delta
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
95-100Subventions
Organisme : NIAID NIH HHS
ID : R01 AI049313
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR048632
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI111224
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
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