Sema7A is crucial for resolution of severe inflammation.
Adolescent
Animals
Antigens, CD
/ genetics
Biomarkers
Cell Plasticity
Child
Child, Preschool
Disease Models, Animal
Disease Susceptibility
Energy Metabolism
Humans
Immunomodulation
Infant
Infant, Newborn
Inflammation
/ etiology
Macrophage Activation
/ immunology
Macrophages
/ immunology
Metabolic Networks and Pathways
Mice
Mice, Knockout
Phagocytosis
/ immunology
Prognosis
Semaphorins
/ genetics
Severity of Illness Index
Signal Transduction
Semaphorin 7A
inflammation
lipid mediator
metabolism
resolution
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
02 03 2021
02 03 2021
Historique:
entrez:
27
2
2021
pubmed:
28
2
2021
medline:
10
8
2021
Statut:
ppublish
Résumé
Endogenous mediators regulating acute inflammatory responses in both the induction and resolution phases of inflammatory processes are pivotal in host defense and tissue homeostasis. Recent studies have identified neuronal guidance proteins characterized in axonal development that display immunomodulatory functions. Here, we identify the neuroimmune guidance cue Semaphorin 7A (Sema7A), which appears to link macrophage (MΦ) metabolic remodeling to inflammation resolution. Sema7A orchestrated MΦ chemotaxis and chemokinesis, activated MΦ differentiation and polarization toward the proresolving M2 phenotype, and promoted leukocyte clearance. Peritoneal MΦ
Identifiants
pubmed: 33637648
pii: 2017527118
doi: 10.1073/pnas.2017527118
pmc: PMC7936270
pii:
doi:
Substances chimiques
Antigens, CD
0
Biomarkers
0
Sema7a protein, mouse
0
Semaphorins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2021 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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