Sarantos Kostidis

Affiliations

Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, the Netherlands.

Publications (30)

Altered Patterns of Compositional and Functional Disruption of the Gut Microbiota in Typhoid Fever and Nontyphoidal Febrile Illness.

Open forum infectious diseases

Avec: Bastiaan W Haak , Hanna K de Jong , Sarantos Kostidis , Martin Giera , Rapeephan R Maude , Rasheda Samad , Lalith Wijedoru , Aniruddha Ghose , Mohammed Abul Faiz , Christopher M Parry , W Joost Wiersinga

Lowering the increased intracellular pH of human-induced pluripotent stem cell-derived endothelial cells induces formation of mature Weibel-Palade bodies.

Stem cells translational medicine

Avec: Gesa L Tiemeier , Rozemarijn de Koning , Gangqi Wang , Sarantos Kostidis , Rosalie G J Rietjens , Wendy M P J Sol , Sébastien J Dumas , Martin Giera , Cathelijne W van den Berg , Jeroen C J Eikenboom , Bernard M van den Berg , Peter Carmeliet , Ton J Rabelink

Metabolomic and lipidomic signatures associated with activation of human cDC1 (BDCA3

Immunology

Avec: Farhan Basit , Tom van Oorschot , Jessie van Buggenum , Rico J E Derks , Sarantos Kostidis , Martin Giera , I Jolanda M de Vries

Spatial dynamic metabolomics identifies metabolic cell fate trajectories in human kidney differentiation.

Cell stem cell

Avec: Gangqi Wang , Bram Heijs , Sarantos Kostidis , Rosalie G J Rietjens , Marije Koning , Lushun Yuan , Gesa L Tiemeier , Ahmed Mahfouz , Sébastien J Dumas , Martin Giera , Jesper Kers , Susana M Chuva de Sousa Lopes , Cathelijne W van den Berg , Bernard M van den Berg , Ton J Rabelink

Dietary butyrate ameliorates metabolic health associated with selective proliferation of gut Lachnospiraceae bacterium 28-4.

JCI insight

Avec: Zhuang Li , Enchen Zhou , Cong Liu , Hope Wicks , Sena Yildiz , Farhana Razack , Zhixiong Ying , Sander Kooijman , Debby PY Koonen , Marieke Heijink , Sarantos Kostidis , Martin Giera , Ingrid MJG Sanders , Ed J Kuijper , Wiep Klaas Smits , Ko Willems van Dijk , Patrick CN Rensen , Yanan Wang

Results of an explorative clinical evaluation suggest immediate and persistent post-reperfusion metabolic paralysis drives kidney ischemia reperfusion injury.

Kidney international

Avec: Jan H Lindeman , Leonie G Wijermars , Sarantos Kostidis , Oleg A Mayboroda , Amy C Harms , Thomas Hankemeier , Jörgen Bierau , Karthick B Sai Sankar Gupta , Martin Giera , Marlies E Reinders , Melissa C Zuiderwijk , Sylvia E Le Dévédec , Alexander F Schaapherder , Jaap A Bakker

Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease.

Cell stem cell

Avec: Elisa Giacomelli , Viviana Meraviglia , Giulia Campostrini , Amy Cochrane , Xu Cao , Ruben W J van Helden , Ana Krotenberg Garcia , Maria Mircea , Sarantos Kostidis , Richard P Davis , Berend J van Meer , Carolina R Jost , Abraham J Koster , Hailiang Mei , David G Míguez , Aat A Mulder , Mario Ledesma-Terrón , Giulio Pompilio , Luca Sala , Daniela C F Salvatori , Roderick C Slieker , Elena Sommariva , Antoine A F de Vries , Martin Giera , Stefan Semrau , Leon G J Tertoolen , Valeria V Orlova , Milena Bellin , Christine L Mummery

Urinary metabolites predict prolonged duration of delayed graft function in DCD kidney transplant recipients.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Avec: S Kostidis , J R Bank , D Soonawala , E Nevedomskaya , C van Kooten , O A Mayboroda , J W de Fijter

Integrative Transkingdom Analysis of the Gut Microbiome in Antibiotic Perturbation and Critical Illness.

mSystems

Avec: Bastiaan W Haak , Ricard Argelaguet , Cormac M Kinsella , Robert F J Kullberg , Jacqueline M Lankelma , Martin Deijs , Michelle Klein , Maarten F Jebbink , Floor Hugenholtz , Sarantos Kostidis , Martin Giera , Theodorus B M Hakvoort , Wouter J de Jonge , Marcus J Schultz , Tom van Gool , Tom van der Poll , Willem M de Vos , Lia M van der Hoek , W Joost Wiersinga

Sema7A is crucial for resolution of severe inflammation.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Andreas Körner , Alice Bernard , Julia C Fitzgerald , Juan Carlos Alarcon-Barrera , Sarantos Kostidis , Torsten Kaussen , Martin Giera , Valbona Mirakaj

Fatty acid desaturation and lipoxygenase pathways support trained immunity.

Nature communications

Avec: Anaísa V Ferreira , Juan Carlos Alarcon-Barrera , Jorge Domínguez-Andrés , Özlem Bulut , Gizem Kilic , Priya A Debisarun , Rutger J Röring , Hatice N Özhan , Eva Terschlüsen , Athanasios Ziogas , Sarantos Kostidis , Yassene Mohammed , Vasiliki Matzaraki , George Renieris , Evangelos J Giamarellos-Bourboulis , Mihai G Netea , Martin Giera

Metabolic Analysis of Vitreous/Lens and Retina in Wild Type and Retinal Degeneration Mice.

International journal of molecular sciences

Avec: Elisa Murenu , Sarantos Kostidis , Shibojyoti Lahiri , Anna S Geserich , Axel Imhof , Martin Giera , Stylianos Michalakis

Immune suppression by human thymus-derived effector Tregs relies on glucose/lactate-fueled fatty acid synthesis.

Cell reports

Avec: Sander de Kivit , Mark Mensink , Sarantos Kostidis , Rico J E Derks , Esther A Zaal , Marieke Heijink , Lotte J Verleng , Evert de Vries , Ellen Schrama , Niek Blomberg , Celia R Berkers , Martin Giera , Jannie Borst

A cell-free nutrient-supplemented perfusate allows four-day ex vivo metabolic preservation of human kidneys.

Nature communications

Avec: Marlon J A de Haan , Marleen E Jacobs , Franca M R Witjas , Annemarie M A de Graaf , Elena Sánchez-López , Sarantos Kostidis , Martin Giera , Francisco Calderon Novoa , Tunpang Chu , Markus Selzner , Mehdi Maanaoui , Dorottya K de Vries , Jesper Kers , Ian P J Alwayn , Cees van Kooten , Bram Heijs , Gangqi Wang , Marten A Engelse , Ton J Rabelink

Lipidomics analysis in drug discovery and development.

Current opinion in chemical biology

Avec: Sarantos Kostidis , Elena Sánchez-López , Martin Giera

The two enantiomers of 2-hydroxyglutarate differentially regulate cytotoxic T cell function.

Cell reports

Avec: Iosifina P Foskolou , Pedro P Cunha , Elena Sánchez-López , Eleanor A Minogue , Benoît P Nicolet , Aurélie Guislain , Christian Jorgensen , Sarantos Kostidis , Nordin D Zandhuis , Laura Barbieri , David Bargiela , Demitris Nathanael , Petros A Tyrakis , Asis Palazon , Martin Giera , Monika C Wolkers , Randall S Johnson

Shear Stress Regulation of Endothelial Glycocalyx Structure Is Determined by Glucobiosynthesis.

Arteriosclerosis, thrombosis, and vascular biology

Avec: Gangqi Wang , Sarantos Kostidis , Gesa L Tiemeier , Wendy M P J Sol , Margreet R de Vries , Martin Giera , Peter Carmeliet , Bernard M van den Berg , Ton J Rabelink

Glutathione Metabolism Contributes to the Induction of Trained Immunity.

Cells

Avec: Anaisa V Ferreira , Valerie A C M Koeken , Vasiliki Matzaraki , Sarantos Kostidis , Juan Carlos Alarcon-Barrera , L Charlotte J de Bree , Simone J C F M Moorlag , Vera P Mourits , Boris Novakovic , Martin A Giera , Mihai G Netea , Jorge Domínguez-Andrés

Bone marrow transplantation induces changes in the gut microbiota that chronically increase the cytokine response pattern of splenocytes.

Scientific reports

Avec: Saeed Katiraei , Janna A van Diepen , Luciana P Tavares , Lisa R Hoving , Amanda Pronk , Ineke Verschueren , Patrick C N Rensen , Jaap Jan Zwaginga , Sarantos Kostidis , Martin Giera , Mauro Teixera , Ko Willems van Dijk , Mihai G Netea , Jimmy F P Berbée , Vanessa van Harmelen

Redirected nuclear glutamate dehydrogenase supplies Tet3 with α-ketoglutarate in neurons.

Nature communications

Avec: Franziska R Traube , Dilara Özdemir , Hanife Sahin , Constanze Scheel , Andrea F Glück , Anna S Geserich , Sabine Oganesian , Sarantos Kostidis , Katharina Iwan , René Rahimoff , Grazia Giorgio , Markus Müller , Fabio Spada , Martin Biel , Jürgen Cox , Martin Giera , Stylianos Michalakis , Thomas Carell

Metabolic Reprogramming of Mammary Epithelial Cells during TGF-β-Induced Epithelial-to-Mesenchymal Transition.

Metabolites

Avec: Wan Hua , Sarantos Kostidis , Oleg Mayboroda , Martin Giera , Marten Hornsveld , Peter Ten Dijke

Metabolomic and Lipidomic Analysis of the Colorectal Adenocarcinoma Cell Line HT29 in Hypoxia and Reoxygenation.

Metabolites

Avec: Juan Carlos Alarcon Barrera , Alejandro Ondo-Mendez , Martin Giera , Sarantos Kostidis

TGFβ-induced metabolic reprogramming during epithelial-to-mesenchymal transition in cancer.

Cellular and molecular life sciences : CMLS

Avec: Wan Hua , Peter Ten Dijke , Sarantos Kostidis , Martin Giera , Marten Hornsveld

Analyzing the impact of Mycobacterium tuberculosis infection on primary human macrophages by combined exploratory and targeted metabolomics.

Scientific reports

Avec: Frank Vrieling , Sarantos Kostidis , Herman P Spaink , Mariëlle C Haks , Oleg A Mayboroda , Tom H M Ottenhoff , Simone A Joosten

Metabolic reprogramming related to whole-chromosome instability in models for Hürthle cell carcinoma.

Scientific reports

Avec: Ruben D Addie , Sarantos Kostidis , Willem E Corver , Jan Oosting , Sepideh Aminzadeh-Gohari , René G Feichtinger , Barbara Kofler , Mehtap Derya Aydemirli , Martin Giera , Hans Morreau

Short-Chain Fatty Acids Improve Poststroke Recovery via Immunological Mechanisms.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Avec: Rebecca Sadler , Julia V Cramer , Steffanie Heindl , Sarantos Kostidis , Dene Betz , Kielen R Zuurbier , Bernd H Northoff , Marieke Heijink , Mark P Goldberg , Erik J Plautz , Stefan Roth , Rainer Malik , Martin Dichgans , Lesca M Holdt , Corinne Benakis , Martin Giera , Ann M Stowe , Arthur Liesz

Recent advances in metabolomics analysis for early drug development.

Drug discovery today

Avec: Juan Carlos Alarcon-Barrera , Sarantos Kostidis , Alejandro Ondo-Mendez , Martin Giera

Analyzing cell-type-specific dynamics of metabolism in kidney repair.

Nature metabolism

Avec: Gangqi Wang , Bram Heijs , Sarantos Kostidis , Ahmed Mahfouz , Rosalie G J Rietjens , Roel Bijkerk , Angela Koudijs , Loïs A K van der Pluijm , Cathelijne W van den Berg , Sébastien J Dumas , Peter Carmeliet , Martin Giera , Bernard M van den Berg , Ton J Rabelink

Dimethyl itaconate induces long-term innate immune responses and confers protection against infection.

Cell reports

Avec: Anaísa V Ferreira , Sarantos Kostidis , Laszlo A Groh , Valerie A C M Koeken , Mariolina Bruno , Ilayda Baydemir , Gizem Kilic , Özlem Bulut , Theano Andriopoulou , Victoria Spanou , Kalliopi D Synodinou , Theologia Gkavogianni , Simone J C F M Moorlag , L Charlotte de Bree , Vera P Mourits , Vasiliki Matzaraki , Werner J H Koopman , Frank L van de Veerdonk , Georgios Renieris , Martin Giera , Evangelos J Giamarellos-Bourboulis , Boris Novakovic , Jorge Domínguez-Andrés

Mis-localization of endogenous TDP-43 leads to ALS-like early-stage metabolic dysfunction and progressive motor deficits.

Molecular neurodegeneration

Avec: Yiying Hu , Alexander Hruscha , Chenchen Pan , Martina Schifferer , Michael K Schmidt , Brigitte Nuscher , Martin Giera , Sarantos Kostidis , Özge Burhan , Frauke van Bebber , Dieter Edbauer , Thomas Arzberger , Christian Haass , Bettina Schmid

Réseau de co-auteurs

Martin Giera 27 collaborations

Gangqi Wang 5 collaborations

Ton J Rabelink 5 collaborations

Bernard M van den Berg 4 collaborations

Juan Carlos Alarcon-Barrera 4 collaborations

Gesa L Tiemeier 3 collaborations

Rosalie G J Rietjens 3 collaborations

Sébastien J Dumas 3 collaborations

Cathelijne W van den Berg 3 collaborations

Peter Carmeliet 3 collaborations

Bram Heijs 3 collaborations

Marieke Heijink 3 collaborations

Jorge Domínguez-Andrés 3 collaborations

Vasiliki Matzaraki 3 collaborations

Mihai G Netea 3 collaborations

Elena Sánchez-López 3 collaborations

Bastiaan W Haak 2 collaborations

W Joost Wiersinga 2 collaborations

Wendy M P J Sol 2 collaborations

Rico J E Derks 2 collaborations

Ahmed Mahfouz 2 collaborations

Jesper Kers 2 collaborations

Ko Willems van Dijk 2 collaborations

Oleg A Mayboroda 2 collaborations

Anaísa V Ferreira 2 collaborations

Özlem Bulut 2 collaborations

Gizem Kilic 2 collaborations

Evangelos J Giamarellos-Bourboulis 2 collaborations

Anna S Geserich 2 collaborations

Stylianos Michalakis 2 collaborations

Valerie A C M Koeken 2 collaborations

Simone J C F M Moorlag 2 collaborations

Vera P Mourits 2 collaborations

Boris Novakovic 2 collaborations

Wan Hua 2 collaborations

Marten Hornsveld 2 collaborations

Peter Ten Dijke 2 collaborations

Alejandro Ondo-Mendez 2 collaborations

Hanna K de Jong 1 collaboration

Rapeephan R Maude 1 collaboration

Rasheda Samad 1 collaboration

Lalith Wijedoru 1 collaboration

Aniruddha Ghose 1 collaboration

Mohammed Abul Faiz 1 collaboration

Christopher M Parry 1 collaboration

Rozemarijn de Koning 1 collaboration

Jeroen C J Eikenboom 1 collaboration

Farhan Basit 1 collaboration

Tom van Oorschot 1 collaboration

Jessie van Buggenum 1 collaboration

I Jolanda M de Vries 1 collaboration

Marije Koning 1 collaboration

Lushun Yuan 1 collaboration

Susana M Chuva de Sousa Lopes 1 collaboration

Zhuang Li 1 collaboration

Enchen Zhou 1 collaboration

Cong Liu 1 collaboration

Hope Wicks 1 collaboration

Sena Yildiz 1 collaboration

Farhana Razack 1 collaboration

Zhixiong Ying 1 collaboration

Sander Kooijman 1 collaboration

Debby PY Koonen 1 collaboration

Ingrid MJG Sanders 1 collaboration

Ed J Kuijper 1 collaboration

Wiep Klaas Smits 1 collaboration

Patrick CN Rensen 1 collaboration

Yanan Wang 1 collaboration

Jan H Lindeman 1 collaboration

Leonie G Wijermars 1 collaboration

Amy C Harms 1 collaboration

Thomas Hankemeier 1 collaboration

Jörgen Bierau 1 collaboration

Karthick B Sai Sankar Gupta 1 collaboration

Marlies E Reinders 1 collaboration

Melissa C Zuiderwijk 1 collaboration

Sylvia E Le Dévédec 1 collaboration

Alexander F Schaapherder 1 collaboration

Jaap A Bakker 1 collaboration

Elisa Giacomelli 1 collaboration

Viviana Meraviglia 1 collaboration

Giulia Campostrini 1 collaboration

Amy Cochrane 1 collaboration

Xu Cao 1 collaboration

Ruben W J van Helden 1 collaboration

Ana Krotenberg Garcia 1 collaboration

Maria Mircea 1 collaboration

Richard P Davis 1 collaboration

Berend J van Meer 1 collaboration

Carolina R Jost 1 collaboration

Abraham J Koster 1 collaboration

Hailiang Mei 1 collaboration

David G Míguez 1 collaboration

Aat A Mulder 1 collaboration

Mario Ledesma-Terrón 1 collaboration

Giulio Pompilio 1 collaboration

Luca Sala 1 collaboration

Daniela C F Salvatori 1 collaboration

Roderick C Slieker 1 collaboration

Elena Sommariva 1 collaboration

Antoine A F de Vries 1 collaboration

Stefan Semrau 1 collaboration

Leon G J Tertoolen 1 collaboration

Valeria V Orlova 1 collaboration

Milena Bellin 1 collaboration

Christine L Mummery 1 collaboration

S Kostidis 1 collaboration

J R Bank 1 collaboration

D Soonawala 1 collaboration

E Nevedomskaya 1 collaboration

C van Kooten 1 collaboration

O A Mayboroda 1 collaboration

J W de Fijter 1 collaboration

Ricard Argelaguet 1 collaboration

Cormac M Kinsella 1 collaboration

Robert F J Kullberg 1 collaboration

Jacqueline M Lankelma 1 collaboration

Martin Deijs 1 collaboration

Michelle Klein 1 collaboration

Maarten F Jebbink 1 collaboration

Floor Hugenholtz 1 collaboration

Theodorus B M Hakvoort 1 collaboration

Wouter J de Jonge 1 collaboration

Marcus J Schultz 1 collaboration

Tom van Gool 1 collaboration

Tom van der Poll 1 collaboration

Willem M de Vos 1 collaboration

Lia M van der Hoek 1 collaboration

Andreas Körner 1 collaboration

Alice Bernard 1 collaboration

Julia C Fitzgerald 1 collaboration

Torsten Kaussen 1 collaboration

Valbona Mirakaj 1 collaboration

Priya A Debisarun 1 collaboration

Rutger J Röring 1 collaboration

Hatice N Özhan 1 collaboration

Eva Terschlüsen 1 collaboration

Athanasios Ziogas 1 collaboration

Yassene Mohammed 1 collaboration

George Renieris 1 collaboration

Elisa Murenu 1 collaboration

Shibojyoti Lahiri 1 collaboration

Axel Imhof 1 collaboration

Sander de Kivit 1 collaboration

Mark Mensink 1 collaboration

Esther A Zaal 1 collaboration

Lotte J Verleng 1 collaboration

Evert de Vries 1 collaboration

Ellen Schrama 1 collaboration

Niek Blomberg 1 collaboration

Celia R Berkers 1 collaboration

Jannie Borst 1 collaboration

Marlon J A de Haan 1 collaboration

Marleen E Jacobs 1 collaboration

Franca M R Witjas 1 collaboration

Annemarie M A de Graaf 1 collaboration

Francisco Calderon Novoa 1 collaboration

Tunpang Chu 1 collaboration

Markus Selzner 1 collaboration

Mehdi Maanaoui 1 collaboration

Dorottya K de Vries 1 collaboration

Ian P J Alwayn 1 collaboration

Cees van Kooten 1 collaboration

Marten A Engelse 1 collaboration

Iosifina P Foskolou 1 collaboration

Pedro P Cunha 1 collaboration

Eleanor A Minogue 1 collaboration

Benoît P Nicolet 1 collaboration

Aurélie Guislain 1 collaboration

Christian Jorgensen 1 collaboration

Nordin D Zandhuis 1 collaboration

Laura Barbieri 1 collaboration

David Bargiela 1 collaboration

Demitris Nathanael 1 collaboration

Petros A Tyrakis 1 collaboration

Asis Palazon 1 collaboration

Monika C Wolkers 1 collaboration

Randall S Johnson 1 collaboration

Margreet R de Vries 1 collaboration

Anaisa V Ferreira 1 collaboration

L Charlotte J de Bree 1 collaboration

Martin A Giera 1 collaboration

Saeed Katiraei 1 collaboration

Janna A van Diepen 1 collaboration

Luciana P Tavares 1 collaboration

Lisa R Hoving 1 collaboration

Amanda Pronk 1 collaboration

Ineke Verschueren 1 collaboration

Patrick C N Rensen 1 collaboration

Jaap Jan Zwaginga 1 collaboration

Mauro Teixera 1 collaboration

Jimmy F P Berbée 1 collaboration

Vanessa van Harmelen 1 collaboration

Franziska R Traube 1 collaboration

Dilara Özdemir 1 collaboration

Hanife Sahin 1 collaboration

Constanze Scheel 1 collaboration

Andrea F Glück 1 collaboration

Sabine Oganesian 1 collaboration

Katharina Iwan 1 collaboration

René Rahimoff 1 collaboration

Grazia Giorgio 1 collaboration

Markus Müller 1 collaboration

Fabio Spada 1 collaboration

Martin Biel 1 collaboration

Jürgen Cox 1 collaboration

Thomas Carell 1 collaboration

Oleg Mayboroda 1 collaboration

Juan Carlos Alarcon Barrera 1 collaboration

Frank Vrieling 1 collaboration

Herman P Spaink 1 collaboration

Mariëlle C Haks 1 collaboration

Tom H M Ottenhoff 1 collaboration

Simone A Joosten 1 collaboration

Ruben D Addie 1 collaboration

Willem E Corver 1 collaboration

Jan Oosting 1 collaboration

Sepideh Aminzadeh-Gohari 1 collaboration

René G Feichtinger 1 collaboration

Barbara Kofler 1 collaboration

Mehtap Derya Aydemirli 1 collaboration

Hans Morreau 1 collaboration

Rebecca Sadler 1 collaboration

Julia V Cramer 1 collaboration

Steffanie Heindl 1 collaboration

Dene Betz 1 collaboration

Kielen R Zuurbier 1 collaboration

Bernd H Northoff 1 collaboration

Mark P Goldberg 1 collaboration

Erik J Plautz 1 collaboration

Stefan Roth 1 collaboration

Rainer Malik 1 collaboration

Martin Dichgans 1 collaboration

Lesca M Holdt 1 collaboration

Corinne Benakis 1 collaboration

Ann M Stowe 1 collaboration

Arthur Liesz 1 collaboration

Roel Bijkerk 1 collaboration

Angela Koudijs 1 collaboration

Loïs A K van der Pluijm 1 collaboration

Laszlo A Groh 1 collaboration

Mariolina Bruno 1 collaboration

Ilayda Baydemir 1 collaboration

Theano Andriopoulou 1 collaboration

Victoria Spanou 1 collaboration

Kalliopi D Synodinou 1 collaboration

Theologia Gkavogianni 1 collaboration

L Charlotte de Bree 1 collaboration

Werner J H Koopman 1 collaboration

Frank L van de Veerdonk 1 collaboration

Georgios Renieris 1 collaboration

Yiying Hu 1 collaboration

Alexander Hruscha 1 collaboration

Chenchen Pan 1 collaboration

Martina Schifferer 1 collaboration

Michael K Schmidt 1 collaboration

Brigitte Nuscher 1 collaboration

Özge Burhan 1 collaboration

Frauke van Bebber 1 collaboration

Dieter Edbauer 1 collaboration

Thomas Arzberger 1 collaboration

Christian Haass 1 collaboration

Bettina Schmid 1 collaboration