Fatty acid desaturation and lipoxygenase pathways support trained immunity.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
15 Nov 2023
15 Nov 2023
Historique:
received:
14
02
2022
accepted:
06
11
2023
medline:
27
11
2023
pubmed:
16
11
2023
entrez:
15
11
2023
Statut:
epublish
Résumé
Infections and vaccines can induce enhanced long-term responses in innate immune cells, establishing an innate immunological memory termed trained immunity. Here, we show that monocytes with a trained immunity phenotype, due to exposure to the Bacillus Calmette-Guérin (BCG) vaccine, are characterized by an increased biosynthesis of different lipid mediators (LM) derived from long-chain polyunsaturated fatty acids (PUFA). Pharmacological and genetic approaches show that long-chain PUFA synthesis and lipoxygenase-derived LM are essential for the BCG-induced trained immunity responses of human monocytes. Furthermore, products of 12-lipoxygenase activity increase in monocytes of healthy individuals after BCG vaccination. Grasping the underscoring lipid metabolic pathways contributes to our understanding of trained immunity and may help to identify therapeutic tools and targets for the modulation of innate immune responses.
Identifiants
pubmed: 37968313
doi: 10.1038/s41467-023-43315-x
pii: 10.1038/s41467-023-43315-x
pmc: PMC10651900
doi:
Substances chimiques
BCG Vaccine
0
Lipoxygenases
EC 1.13.11.-
Lipids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
7385Informations de copyright
© 2023. The Author(s).
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