Metabolomic and lipidomic signatures associated with activation of human cDC1 (BDCA3
Amino Acids
/ metabolism
Biomarkers
Cytokines
/ metabolism
Dendritic Cells
/ immunology
Humans
Immunophenotyping
Lipid Metabolism
Lipidomics
/ methods
Lipopolysaccharide Receptors
/ metabolism
Metabolic Networks and Pathways
Metabolome
Metabolomics
Oxidative Phosphorylation
Thrombomodulin
/ metabolism
Toll-Like Receptors
/ metabolism
BDCA3
dendritic cell activation
lipid mediators
metabolomics
Journal
Immunology
ISSN: 1365-2567
Titre abrégé: Immunology
Pays: England
ID NLM: 0374672
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
revised:
17
06
2021
received:
07
01
2021
accepted:
06
07
2021
pubmed:
26
8
2021
medline:
22
2
2022
entrez:
25
8
2021
Statut:
ppublish
Résumé
Dendritic cells (DCs) bridge the connection between innate and adaptive immunity. DCs present antigens to T cells and stimulate potent cytotoxic T-cell responses. Metabolic reprogramming is critical for DC development and activation; however, metabolic adaptations and regulation in DC subsets remains largely uncharacterized. Here, we mapped metabolomic and lipidomic signatures associated with the activation phenotype of human conventional DC type 1, a DC subset specialized in cross-presentation and therefore of major importance for the stimulation of CD8
Identifiants
pubmed: 34431087
doi: 10.1111/imm.13409
pmc: PMC9426619
doi:
Substances chimiques
Amino Acids
0
Biomarkers
0
Cytokines
0
Lipopolysaccharide Receptors
0
THBD protein, human
0
Thrombomodulin
0
Toll-Like Receptors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
99-109Informations de copyright
© 2021 The Authors. Immunology published by John Wiley & Sons Ltd.
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