Metabolic Analysis of Vitreous/Lens and Retina in Wild Type and Retinal Degeneration Mice.
degeneration
eye opening
metabolism
physiology
retina
vitreous/lens
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
26 Feb 2021
26 Feb 2021
Historique:
received:
29
01
2021
revised:
19
02
2021
accepted:
23
02
2021
entrez:
3
3
2021
pubmed:
4
3
2021
medline:
20
4
2021
Statut:
epublish
Résumé
Photoreceptors are the light-sensing cells of the retina and the major cell type affected in most inherited retinal degenerations. Different metabolic pathways sustain their high energetic demand in physiological conditions, particularly aerobic glycolysis. The principal metabolome of the mature retina has been studied, but only limited information is available on metabolic adaptations in response to key developmental events, such as eye opening. Moreover, dynamic metabolic changes due to retinal degeneration are not well understood. Here, we aimed to explore and map the ocular metabolic dynamics induced by eye opening in healthy (wild type) or
Identifiants
pubmed: 33652907
pii: ijms22052345
doi: 10.3390/ijms22052345
pmc: PMC7956175
pii:
doi:
Substances chimiques
Cyclic Nucleotide Phosphodiesterases, Type 6
EC 3.1.4.35
Pde6b protein, mouse
EC 3.1.4.35
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : EXC114
Organisme : Deutsche Forschungsgemeinschaft
ID : CRC1309
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.
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