TGFβ-induced metabolic reprogramming during epithelial-to-mesenchymal transition in cancer.
Cancer
Choline metabolism
EMT
Glycolysis
Lipid metabolism
Mitochondrial metabolism
Signal transduction
TGFβ
Journal
Cellular and molecular life sciences : CMLS
ISSN: 1420-9071
Titre abrégé: Cell Mol Life Sci
Pays: Switzerland
ID NLM: 9705402
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
26
08
2019
accepted:
26
11
2019
revised:
10
11
2019
pubmed:
12
12
2019
medline:
17
6
2020
entrez:
12
12
2019
Statut:
ppublish
Résumé
Metastasis is the most frequent cause of death in cancer patients. Epithelial-to-mesenchymal transition (EMT) is the process in which cells lose epithelial integrity and become motile, a critical step for cancer cell invasion, drug resistance and immune evasion. The transforming growth factor-β (TGFβ) signaling pathway is a major driver of EMT. Increasing evidence demonstrates that metabolic reprogramming is a hallmark of cancer and extensive metabolic changes are observed during EMT. The aim of this review is to summarize and interconnect recent findings that illustrate how changes in glycolysis, mitochondrial, lipid and choline metabolism coincide and functionally contribute to TGFβ-induced EMT. We describe TGFβ signaling is involved in stimulating both glycolysis and mitochondrial respiration. Interestingly, the subsequent metabolic consequences for the redox state and lipid metabolism in cancer cells are found to be in favor of EMT as well. Combined we illustrate that a better understanding of the mechanistic links between TGFβ signaling, cancer metabolism and EMT holds promising strategies for cancer therapy, some of which are already actively being explored in the clinic.
Identifiants
pubmed: 31822964
doi: 10.1007/s00018-019-03398-6
pii: 10.1007/s00018-019-03398-6
pmc: PMC7256023
doi:
Substances chimiques
Transforming Growth Factor beta
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2103-2123Subventions
Organisme : Center for Cancer Genomics
ID : CCG.NL
Organisme : Chinese Scholarship Council
ID : CSC
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