Placental mobilization of free fatty acids contributes to altered materno-fetal transfer in obesity.
Journal
International journal of obesity (2005)
ISSN: 1476-5497
Titre abrégé: Int J Obes (Lond)
Pays: England
ID NLM: 101256108
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
received:
24
04
2020
accepted:
01
02
2021
revised:
08
01
2021
pubmed:
28
2
2021
medline:
24
12
2021
entrez:
27
2
2021
Statut:
ppublish
Résumé
Metabolic changes in obese pregnant women, such as changes of plasma lipids beyond physiological levels, may subsequently affect fetal development in utero. These metabolic derangements may remain in the offspring and continue throughout life. The placenta mediates bidirectional exchange of nutrients between mother and fetus. The impact of prepregnancy obesity on placental transfer of lipids is still unknown. We aimed to examine materno-to-fetal free fatty acid (FFA) transfer by a combined experimental and modeling approach. Flux of Obesity was strongly associated with elevated materno-to-fetal transfer of applied Besides direct materno-to-fetal FFA transfer, placental mobilization accounts for the fetal FA supply. Together, with metabolic changes in the mother and an elevated materno-fetal FFA transfer shown in obesity, these changes suggest that they may be transmitted to the fetus, with yet unknown consequences.
Sections du résumé
BACKGROUND
Metabolic changes in obese pregnant women, such as changes of plasma lipids beyond physiological levels, may subsequently affect fetal development in utero. These metabolic derangements may remain in the offspring and continue throughout life. The placenta mediates bidirectional exchange of nutrients between mother and fetus. The impact of prepregnancy obesity on placental transfer of lipids is still unknown.
OBJECTIVE
We aimed to examine materno-to-fetal free fatty acid (FFA) transfer by a combined experimental and modeling approach. Flux of
RESULTS
Obesity was strongly associated with elevated materno-to-fetal transfer of applied
CONCLUSION
Besides direct materno-to-fetal FFA transfer, placental mobilization accounts for the fetal FA supply. Together, with metabolic changes in the mother and an elevated materno-fetal FFA transfer shown in obesity, these changes suggest that they may be transmitted to the fetus, with yet unknown consequences.
Identifiants
pubmed: 33637949
doi: 10.1038/s41366-021-00781-x
pii: 10.1038/s41366-021-00781-x
pmc: PMC8081658
doi:
Substances chimiques
Fatty Acids, Nonesterified
0
Docosahexaenoic Acids
25167-62-8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1114-1123Références
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