A supercritical fluid workflow for the quality assessment of herbal drugs and commercial preparations from Rhodiola rosea.
Rhodiola rosea
SFC
SFE
commercial product
herbal drug
quality control
Journal
Phytochemical analysis : PCA
ISSN: 1099-1565
Titre abrégé: Phytochem Anal
Pays: England
ID NLM: 9200492
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
revised:
12
02
2021
received:
19
11
2020
accepted:
12
02
2021
pubmed:
28
2
2021
medline:
13
10
2021
entrez:
27
2
2021
Statut:
ppublish
Résumé
Preparations from the Rhodiola rosea are experiencing an increase in popularity: extracts of dried roots and rhizomes are used as adaptogen to treat stress, fatigue, and weakness. To meet high pharmaceutical standards, fast and reliable methods to assess phytochemical variations in respect of quality control are needed. The aim of this study was to extract and quantify seven characteristic secondary metabolites of R. rosea, namely p-tyrosol (1), rosin (2), rosiridin (3), salidroside (4), rosarin (5), rosavin (6), and tricin-5-O-β-d-glucopyranoside (7) in 24 herbal drugs and seven commercial preparations using a newly established supercritical fluid workflow. The developed protocol allowed for an exhaustive extraction of compounds 1-7 using 60% carbon dioxide (CO The seven compounds were separated in a remarkably short time (< 3.5 minutes). For their quantitation, good results in terms of selectivity, linearity (R The quantitative analysis of the investigated herbal drugs showed a highly differing metabolite pattern which was also observed in the investigated commercial products. None of the commercial dietary products met the declared content of rosavins and salidroside. The developed and validated protocol offers a novel and reliable method to assess the quantitative composition of Rhodiola herbal drugs and preparations.
Identifiants
pubmed: 33638206
doi: 10.1002/pca.3040
pmc: PMC8596633
doi:
Substances chimiques
Plant Extracts
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
982-991Subventions
Organisme : Wilhelm Doerenkamp Foundation, Chur, Switzerland
ID : Natvantage Grant 2018
Informations de copyright
© 2021 The Authors. Phytochemical Analysis published by John Wiley & Sons Ltd.
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