Cancer cell heterogeneity & plasticity in glioblastoma and brain tumors.
Epigenetics
Glioblastoma
Heterogeneity
Plasticity
Tumor microenvironment
Journal
Seminars in cancer biology
ISSN: 1096-3650
Titre abrégé: Semin Cancer Biol
Pays: England
ID NLM: 9010218
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
received:
01
12
2020
accepted:
22
02
2021
pubmed:
1
3
2021
medline:
18
5
2022
entrez:
28
2
2021
Statut:
ppublish
Résumé
Brain tumors remain one of the most difficult tumors to treat and, depending on the diagnosis, have a poor prognosis. Of brain tumors, glioblastoma (GBM) is the most common malignant glioma and has a dismal prognosis, with only about 5% of patients alive five years after diagnosis. While advances in targeted therapies and immunotherapies are rapidly improving outcomes in a variety of other cancers, the standard of care for GBM has largely remained unaltered since 2005. There are many well-studied challenges that are either unique to brain tumors (i.e., blood-brain barrier and immunosuppressive environment) or amplified within GBM (i.e., tumor heterogeneity at the cellular and molecular levels, plasticity, and cancer stem cells) that make this disease particularly difficult to treat. While we touch on all these concepts, the focus of this review is to discuss the immense inter- and intra-tumoral heterogeneity and advances in our understanding of tumor cell plasticity and epigenetics in GBM. With each improvement in technology, our understanding of the complexity of tumoral heterogeneity and plasticity improves and we gain more clarity on the causes underlying previous therapeutic failures. However, these advances are unlocking new therapeutic opportunities that scientists and physicians are currently exploiting and have the potential for new breakthroughs.
Identifiants
pubmed: 33640445
pii: S1044-579X(21)00049-3
doi: 10.1016/j.semcancer.2021.02.014
pmc: PMC9618157
mid: NIHMS1842981
pii:
doi:
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
162-175Subventions
Organisme : NCI NIH HHS
ID : F30 CA250254
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA245705
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS109742
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS117104
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
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