Adam Lauko

Affiliations

Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44106, USA; Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44106, USA; Medical Scientist Training Program, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA.

Publications (22)

SerpinB3 drives cancer stem cell survival in glioblastoma.

Cell reports

Avec: Adam Lauko , Josephine Volovetz , Soumya M Turaga , Defne Bayik , Daniel J Silver , Kelly Mitchell , Erin E Mulkearns-Hubert , Dionysios C Watson , Kiran Desai , Manav Midha , Jing Hao , Kathleen McCortney , Alicia Steffens , Ulhas Naik , Manmeet S Ahluwalia , Shideng Bao , Craig Horbinski , Jennifer S Yu , Justin D Lathia

Accurate de novo design of membrane-traversing macrocycles.

Cell

Avec: Gaurav Bhardwaj , Jacob O'Connor , Stephen Rettie , Yen-Hua Huang , Theresa A Ramelot , Vikram Khipple Mulligan , Gizem Gokce Alpkilic , Jonathan Palmer , Asim K Bera , Matthew J Bick , Maddalena Di Piazza , Xinting Li , Parisa Hosseinzadeh , Timothy W Craven , Roberto Tejero , Anna Lauko , Ryan Choi , Calina Glynn , Linlin Dong , Robert Griffin , Wesley C van Voorhis , Jose Rodriguez , Lance Stewart , Gaetano T Montelione , David Craik , David Baker

Glioblastoma Myeloid-Derived Suppressor Cell Subsets Express Differential Macrophage Migration Inhibitory Factor Receptor Profiles That Can Be Targeted to Reduce Immune Suppression.

Frontiers in immunology

Avec: Tyler J Alban , Defne Bayik , Balint Otvos , Anja Rabljenovic , Lin Leng , Leu Jia-Shiun , Gustavo Roversi , Adam Lauko , Arbaz A Momin , Alireza M Mohammadi , David M Peereboom , Manmeet S Ahluwalia , Kazuko Matsuda , Kyuson Yun , Richard Bucala , Michael A Vogelbaum , Justin D Lathia

Identifying conserved molecular targets required for cell migration of glioblastoma cancer stem cells.

Cell death & disease

Avec: Josephine Volovetz , Artem D Berezovsky , Tyler Alban , Yujun Chen , Adam Lauko , George F Aranjuez , Ashley Burtscher , Kelly Shibuya , Daniel J Silver , John Peterson , Danny Manor , Jocelyn A McDonald , Justin D Lathia

Neutrophil to lymphocyte ratio influences impact of steroids on efficacy of immune checkpoint inhibitors in lung cancer brain metastases.

Scientific reports

Avec: Adam Lauko , Bicky Thapa , Mayur Sharma , Baha'eddin Muhsen , Addison Barnett , Yasmeen Rauf , Hamid Borghei-Razavi , Vineeth Tatineni , Pradnya Patil , Alireza Mohammadi , Samuel Chao , Erin S Murphy , Lilyana Angelov , John Suh , Gene H Barnett , Amy S Nowacki , Nathan Pennell , Manmeet S Ahluwalia

Distinct Cell Adhesion Signature Defines Glioblastoma Myeloid-Derived Suppressor Cell Subsets.

Cancer research

Avec: Defne Bayik , Cynthia F Bartels , Katreya Lovrenert , Dionysios C Watson , Duo Zhang , Kristen Kay , Juyeun Lee , Adam Lauko , Sadie Johnson , Alice Lo , Daniel J Silver , Mary McGraw , Matthew Grabowski , Alireza M Mohammadi , Filippo Veglia , Yi Fan , Michael A Vogelbaum , Peter Scacheri , Justin D Lathia

Deep learning enables the atomic structure determination of the Fanconi Anemia core complex from cryoEM.

IUCrJ

Avec: Daniel P Farrell , Ivan Anishchenko , Shabih Shakeel , Anna Lauko , Lori A Passmore , David Baker , Frank DiMaio

De novo design of protein structure and function with RFdiffusion.

Nature

Avec: Joseph L Watson , David Juergens , Nathaniel R Bennett , Brian L Trippe , Jason Yim , Helen E Eisenach , Woody Ahern , Andrew J Borst , Robert J Ragotte , Lukas F Milles , Basile I M Wicky , Nikita Hanikel , Samuel J Pellock , Alexis Courbet , William Sheffler , Jue Wang , Preetham Venkatesh , Isaac Sappington , Susana Vázquez Torres , Anna Lauko , Valentin De Bortoli , Emile Mathieu , Sergey Ovchinnikov , Regina Barzilay , Tommi S Jaakkola , Frank DiMaio , Minkyung Baek , David Baker

The MIF promoter SNP rs755622 is associated with immune activation in glioblastoma.

JCI insight

Avec: Tyler J Alban , Matthew M Grabowski , Balint Otvos , Defne Bayik , Wesley Wang , Ajay Zalavadia , Vlad Makarov , Katie Troike , Mary McGraw , Anja Rabljenovic , Adam Lauko , Chase Neumann , Gustavo Roversi , Kristin A Waite , Gino Cioffi , Nirav Patil , Thuy T Tran , Kathleen McCortney , Alicia Steffens , C Marcela Diaz , J Mark Brown , Kathleen M Egan , Craig M Horbinski , Jill S Barnholtz-Sloan , Prajwal Rajappa , Michael A Vogelbaum , Richard Bucala , Timothy A Chan , Manmeet S Ahluwalia , Justin D Lathia

Myeloid-Derived Suppressor Cell Subsets Drive Glioblastoma Growth in a Sex-Specific Manner.

Cancer discovery

Avec: Defne Bayik , Yadi Zhou , Chihyun Park , Changjin Hong , Daniel Vail , Daniel J Silver , Adam Lauko , Gustavo Roversi , Dionysios C Watson , Alice Lo , Tyler J Alban , Mary McGraw , Mia Sorensen , Matthew M Grabowski , Balint Otvos , Michael A Vogelbaum , Craig Horbinski , Bjarne Winther Kristensen , Ahmad M Khalil , Tae Hyun Hwang , Manmeet S Ahluwalia , Feixiong Cheng , Justin D Lathia

Junctional Adhesion Molecules in Cancer: A Paradigm for the Diverse Functions of Cell-Cell Interactions in Tumor Progression.

Cancer research

Avec: Adam Lauko , Zhaomei Mu , David H Gutmann , Ulhas P Naik , Justin D Lathia

Cancer cell heterogeneity & plasticity in glioblastoma and brain tumors.

Seminars in cancer biology

Avec: Adam Lauko , Alice Lo , Manmeet S Ahluwalia , Justin D Lathia

WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma.

Genes & development

Avec: Kelly Mitchell , Samuel A Sprowls , Sonali Arora , Sajina Shakya , Daniel J Silver , Christopher M Goins , Lisa Wallace , Gustavo Roversi , Rachel E Schafer , Kristen Kay , Tyler E Miller , Adam Lauko , John Bassett , Anjali Kashyap , Jonathan D'Amato Kass , Erin E Mulkearns-Hubert , Sadie Johnson , Joseph Alvarado , Jeremy N Rich , Eric C Holland , Patrick J Paddison , Anoop P Patel , Shaun R Stauffer , Christopher G Hubert , Justin D Lathia

GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumorigenicity.

Nature cancer

Avec: Dionysios C Watson , Defne Bayik , Simon Storevik , Shannon Sherwin Moreino , Samuel A Sprowls , Jianhua Han , Mina Thue Augustsson , Adam Lauko , Palavalasa Sravya , Gro Vatne Røsland , Katie Troike , Karl Johan Tronstad , Sabrina Wang , Katharina Sarnow , Kristen Kay , Taral R Lunavat , Daniel J Silver , Sahil Dayal , Justin Vareecal Joseph , Erin Mulkearns-Hubert , Lars Andreas Rømo Ystaas , Gauravi Deshpande , Joris Guyon , Yadi Zhou , Capucine R Magaut , Juliana Seder , Laura Neises , Sarah E Williford , Johannes Meiser , Andrew J Scott , Peter Sajjakulnukit , Jason A Mears , Rolf Bjerkvig , Abhishek Chakraborty , Thomas Daubon , Feixiong Cheng , Costas A Lyssiotis , Daniel R Wahl , Anita B Hjelmeland , Jubayer A Hossain , Hrvoje Miletic , Justin D Lathia

Modeling protein-small molecule conformational ensembles with ChemNet.

bioRxiv : the preprint server for biology

Avec: Ivan Anishchenko , Yakov Kipnis , Indrek Kalvet , Guangfeng Zhou , Rohith Krishna , Samuel J Pellock , Anna Lauko , Gyu Rie Lee , Linna An , Justas Dauparas , Frank DiMaio , David Baker

JAM-A functions as a female microglial tumor suppressor in glioblastoma.

Neuro-oncology

Avec: Soumya M Turaga , Daniel J Silver , Defne Bayik , Evi Paouri , Sen Peng , Adam Lauko , Tyler J Alban , Nozha Borjini , Sarah Stanko , Ulhas P Naik , Ruth A Keri , James R Connor , Jill S Barnholtz-Sloan , Joshua B Rubin , Michael Berens , Dimitrios Davalos , Justin D Lathia

Medical management of brain metastases.

Neuro-oncology advances

Avec: Adam Lauko , Yasmeen Rauf , Manmeet S Ahluwalia

Safety of allogeneic hematopoietic stem cell transplantation in beta-thalassemia patients with chronic hepatitis C infections treated at a pediatric center.

Pediatric transplantation

Avec: Archana Ramgopal , Adam Lauko , Seth Rotz , Rabi Hanna

Impact of KRAS mutation status on the efficacy of immunotherapy in lung cancer brain metastases.

Scientific reports

Avec: Adam Lauko , Rupesh Kotecha , Addison Barnett , Hong Li , Vineeth Tatineni , Assad Ali , Pradnya Patil , Alireza M Mohammadi , Samuel T Chao , Erin S Murphy , Lilyana Angelov , John H Suh , Gene H Barnett , Nathan A Pennell , Manmeet S Ahluwalia

Spatial immunosampling of MRI-defined glioblastoma regions reveals immunologic fingerprint of non-contrast enhancing, infiltrative tumor margins.

medRxiv : the preprint server for health sciences

Avec: Matthew M Grabowski , Dionysios C Watson , Kunho Chung , Juyeun Lee , Defne Bayik , Adam Lauko , Tyler Alban , Jan Joseph Melenhorst , Timothy Chan , Justin D Lathia , Manmeet S Ahluwalia , Alireza M Mohammadi

Sex-Biased T-cell Exhaustion Drives Differential Immune Responses in Glioblastoma.

Cancer discovery

Avec: Juyeun Lee , Michael Nicosia , Ellen S Hong , Daniel J Silver , Cathy Li , Defne Bayik , Dionysios C Watson , Adam Lauko , Kristen E Kay , Sabrina Z Wang , Sadie Johnson , Mary McGraw , Matthew M Grabowski , Danielle D Kish , Amar B Desai , Wendy A Goodman , Scott J Cameron , Hideho Okada , Anna Valujskikh , Robert L Fairchild , Manmeet S Ahluwalia , Justin D Lathia

Computational design of serine hydrolases.

bioRxiv : the preprint server for biology

Avec: Anna Lauko , Samuel J Pellock , Ivan Anischanka , Kiera H Sumida , David Juergens , Woody Ahern , Alex Shida , Andrew Hunt , Indrek Kalvet , Christoffer Norn , Ian R Humphreys , Cooper Jamieson , Alex Kang , Evans Brackenbrough , Asim K Bera , Banumathi Sankaran , K N Houk , David Baker

Réseau de co-auteurs

Justin D Lathia 13 collaborations

Manmeet S Ahluwalia 10 collaborations

Defne Bayik 9 collaborations

Daniel J Silver 8 collaborations

Dionysios C Watson 6 collaborations

Anna Lauko 5 collaborations

David Baker 5 collaborations

Tyler J Alban 4 collaborations

Gustavo Roversi 4 collaborations

Alireza M Mohammadi 4 collaborations

Michael A Vogelbaum 4 collaborations

Mary McGraw 4 collaborations

Matthew M Grabowski 4 collaborations

Balint Otvos 3 collaborations

Kristen Kay 3 collaborations

Juyeun Lee 3 collaborations

Sadie Johnson 3 collaborations

Alice Lo 3 collaborations

Frank DiMaio 3 collaborations

Samuel J Pellock 3 collaborations

Josephine Volovetz 2 collaborations

Soumya M Turaga 2 collaborations

Kelly Mitchell 2 collaborations

Erin E Mulkearns-Hubert 2 collaborations

Kathleen McCortney 2 collaborations

Alicia Steffens 2 collaborations

Craig Horbinski 2 collaborations

Asim K Bera 2 collaborations

Anja Rabljenovic 2 collaborations

Richard Bucala 2 collaborations

Tyler Alban 2 collaborations

Addison Barnett 2 collaborations

Yasmeen Rauf 2 collaborations

Vineeth Tatineni 2 collaborations

Pradnya Patil 2 collaborations

Erin S Murphy 2 collaborations

Lilyana Angelov 2 collaborations

Gene H Barnett 2 collaborations

Ivan Anishchenko 2 collaborations

David Juergens 2 collaborations

Woody Ahern 2 collaborations

Katie Troike 2 collaborations

Jill S Barnholtz-Sloan 2 collaborations

Yadi Zhou 2 collaborations

Feixiong Cheng 2 collaborations

Ulhas P Naik 2 collaborations

Samuel A Sprowls 2 collaborations

Indrek Kalvet 2 collaborations

Kiran Desai 1 collaboration

Manav Midha 1 collaboration

Jing Hao 1 collaboration

Ulhas Naik 1 collaboration

Shideng Bao 1 collaboration

Jennifer S Yu 1 collaboration

Gaurav Bhardwaj 1 collaboration

Jacob O'Connor 1 collaboration

Stephen Rettie 1 collaboration

Yen-Hua Huang 1 collaboration

Theresa A Ramelot 1 collaboration

Vikram Khipple Mulligan 1 collaboration

Gizem Gokce Alpkilic 1 collaboration

Jonathan Palmer 1 collaboration

Matthew J Bick 1 collaboration

Maddalena Di Piazza 1 collaboration

Xinting Li 1 collaboration

Parisa Hosseinzadeh 1 collaboration

Timothy W Craven 1 collaboration

Roberto Tejero 1 collaboration

Ryan Choi 1 collaboration

Calina Glynn 1 collaboration

Linlin Dong 1 collaboration

Robert Griffin 1 collaboration

Wesley C van Voorhis 1 collaboration

Jose Rodriguez 1 collaboration

Lance Stewart 1 collaboration

Gaetano T Montelione 1 collaboration

David Craik 1 collaboration

Lin Leng 1 collaboration

Leu Jia-Shiun 1 collaboration

Arbaz A Momin 1 collaboration

David M Peereboom 1 collaboration

Kazuko Matsuda 1 collaboration

Kyuson Yun 1 collaboration

Artem D Berezovsky 1 collaboration

Yujun Chen 1 collaboration

George F Aranjuez 1 collaboration

Ashley Burtscher 1 collaboration

Kelly Shibuya 1 collaboration

John Peterson 1 collaboration

Danny Manor 1 collaboration

Jocelyn A McDonald 1 collaboration

Bicky Thapa 1 collaboration

Mayur Sharma 1 collaboration

Baha'eddin Muhsen 1 collaboration

Hamid Borghei-Razavi 1 collaboration

Alireza Mohammadi 1 collaboration

Samuel Chao 1 collaboration

John Suh 1 collaboration

Amy S Nowacki 1 collaboration

Nathan Pennell 1 collaboration

Cynthia F Bartels 1 collaboration

Katreya Lovrenert 1 collaboration

Duo Zhang 1 collaboration

Matthew Grabowski 1 collaboration

Filippo Veglia 1 collaboration

Yi Fan 1 collaboration

Peter Scacheri 1 collaboration

Daniel P Farrell 1 collaboration

Shabih Shakeel 1 collaboration

Lori A Passmore 1 collaboration

Joseph L Watson 1 collaboration

Nathaniel R Bennett 1 collaboration

Brian L Trippe 1 collaboration

Jason Yim 1 collaboration

Helen E Eisenach 1 collaboration

Andrew J Borst 1 collaboration

Robert J Ragotte 1 collaboration

Lukas F Milles 1 collaboration

Basile I M Wicky 1 collaboration

Nikita Hanikel 1 collaboration

Alexis Courbet 1 collaboration

William Sheffler 1 collaboration

Jue Wang 1 collaboration

Preetham Venkatesh 1 collaboration

Isaac Sappington 1 collaboration

Susana Vázquez Torres 1 collaboration

Valentin De Bortoli 1 collaboration

Emile Mathieu 1 collaboration

Sergey Ovchinnikov 1 collaboration

Regina Barzilay 1 collaboration

Tommi S Jaakkola 1 collaboration

Minkyung Baek 1 collaboration

Wesley Wang 1 collaboration

Ajay Zalavadia 1 collaboration

Vlad Makarov 1 collaboration

Chase Neumann 1 collaboration

Kristin A Waite 1 collaboration

Gino Cioffi 1 collaboration

Nirav Patil 1 collaboration

Thuy T Tran 1 collaboration

C Marcela Diaz 1 collaboration

J Mark Brown 1 collaboration

Kathleen M Egan 1 collaboration

Craig M Horbinski 1 collaboration

Prajwal Rajappa 1 collaboration

Timothy A Chan 1 collaboration

Chihyun Park 1 collaboration

Changjin Hong 1 collaboration

Daniel Vail 1 collaboration

Mia Sorensen 1 collaboration

Bjarne Winther Kristensen 1 collaboration

Ahmad M Khalil 1 collaboration

Tae Hyun Hwang 1 collaboration

Zhaomei Mu 1 collaboration

David H Gutmann 1 collaboration

Sonali Arora 1 collaboration

Sajina Shakya 1 collaboration

Christopher M Goins 1 collaboration

Lisa Wallace 1 collaboration

Rachel E Schafer 1 collaboration

Tyler E Miller 1 collaboration

John Bassett 1 collaboration

Anjali Kashyap 1 collaboration

Jonathan D'Amato Kass 1 collaboration

Joseph Alvarado 1 collaboration

Jeremy N Rich 1 collaboration

Eric C Holland 1 collaboration

Patrick J Paddison 1 collaboration

Anoop P Patel 1 collaboration

Shaun R Stauffer 1 collaboration

Christopher G Hubert 1 collaboration

Simon Storevik 1 collaboration

Shannon Sherwin Moreino 1 collaboration

Jianhua Han 1 collaboration

Mina Thue Augustsson 1 collaboration

Palavalasa Sravya 1 collaboration

Gro Vatne Røsland 1 collaboration

Karl Johan Tronstad 1 collaboration

Sabrina Wang 1 collaboration

Katharina Sarnow 1 collaboration

Taral R Lunavat 1 collaboration

Sahil Dayal 1 collaboration

Justin Vareecal Joseph 1 collaboration

Erin Mulkearns-Hubert 1 collaboration

Lars Andreas Rømo Ystaas 1 collaboration

Gauravi Deshpande 1 collaboration

Joris Guyon 1 collaboration

Capucine R Magaut 1 collaboration

Juliana Seder 1 collaboration

Laura Neises 1 collaboration

Sarah E Williford 1 collaboration

Johannes Meiser 1 collaboration

Andrew J Scott 1 collaboration

Peter Sajjakulnukit 1 collaboration

Jason A Mears 1 collaboration

Rolf Bjerkvig 1 collaboration

Abhishek Chakraborty 1 collaboration

Thomas Daubon 1 collaboration

Costas A Lyssiotis 1 collaboration

Daniel R Wahl 1 collaboration

Anita B Hjelmeland 1 collaboration

Jubayer A Hossain 1 collaboration

Hrvoje Miletic 1 collaboration

Yakov Kipnis 1 collaboration

Guangfeng Zhou 1 collaboration

Rohith Krishna 1 collaboration

Gyu Rie Lee 1 collaboration

Linna An 1 collaboration

Justas Dauparas 1 collaboration

Evi Paouri 1 collaboration

Sen Peng 1 collaboration

Nozha Borjini 1 collaboration

Sarah Stanko 1 collaboration

Ruth A Keri 1 collaboration

James R Connor 1 collaboration

Joshua B Rubin 1 collaboration

Michael Berens 1 collaboration

Dimitrios Davalos 1 collaboration

Archana Ramgopal 1 collaboration

Seth Rotz 1 collaboration

Rabi Hanna 1 collaboration

Rupesh Kotecha 1 collaboration

Hong Li 1 collaboration

Assad Ali 1 collaboration

Samuel T Chao 1 collaboration

John H Suh 1 collaboration

Nathan A Pennell 1 collaboration

Kunho Chung 1 collaboration

Jan Joseph Melenhorst 1 collaboration

Timothy Chan 1 collaboration

Michael Nicosia 1 collaboration

Ellen S Hong 1 collaboration

Cathy Li 1 collaboration

Kristen E Kay 1 collaboration

Sabrina Z Wang 1 collaboration

Danielle D Kish 1 collaboration

Amar B Desai 1 collaboration

Wendy A Goodman 1 collaboration

Scott J Cameron 1 collaboration

Hideho Okada 1 collaboration

Anna Valujskikh 1 collaboration

Robert L Fairchild 1 collaboration

Ivan Anischanka 1 collaboration

Kiera H Sumida 1 collaboration

Alex Shida 1 collaboration

Andrew Hunt 1 collaboration

Christoffer Norn 1 collaboration

Ian R Humphreys 1 collaboration

Cooper Jamieson 1 collaboration

Alex Kang 1 collaboration

Evans Brackenbrough 1 collaboration

Banumathi Sankaran 1 collaboration

K N Houk 1 collaboration