The MIF promoter SNP rs755622 is associated with immune activation in glioblastoma.
Brain cancer
Cellular immune response
Immunology
Immunotherapy
Oncology
Journal
JCI insight
ISSN: 2379-3708
Titre abrégé: JCI Insight
Pays: United States
ID NLM: 101676073
Informations de publication
Date de publication:
10 07 2023
10 07 2023
Historique:
received:
09
03
2022
accepted:
25
05
2023
medline:
11
7
2023
pubmed:
30
5
2023
entrez:
30
5
2023
Statut:
epublish
Résumé
Intratumoral heterogeneity is a defining hallmark of glioblastoma, driving drug resistance and ultimately recurrence. Many somatic drivers of microenvironmental change have been shown to affect this heterogeneity and, ultimately, the treatment response. However, little is known about how germline mutations affect the tumoral microenvironment. Here, we find that the single-nucleotide polymorphism (SNP) rs755622 in the promoter of the cytokine macrophage migration inhibitory factor (MIF) is associated with increased leukocyte infiltration in glioblastoma. Furthermore, we identified an association between rs755622 and lactotransferrin expression, which could also be used as a biomarker for immune-infiltrated tumors. These findings demonstrate that a germline SNP in the promoter region of MIF may affect the immune microenvironment and further reveal a link between lactotransferrin and immune activation.
Identifiants
pubmed: 37252795
pii: 160024
doi: 10.1172/jci.insight.160024
pmc: PMC10371339
doi:
pii:
Substances chimiques
Lactoferrin
EC 3.4.21.-
Macrophage Migration-Inhibitory Factors
0
MIF protein, human
EC 5.3.2.1
Intramolecular Oxidoreductases
EC 5.3.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCI NIH HHS
ID : R35 CA232097
Pays : United States
Organisme : NCI NIH HHS
ID : K12 CA215110
Pays : United States
Organisme : NCI NIH HHS
ID : F30 CA250254
Pays : United States
Organisme : NCI NIH HHS
ID : K99 CA248611
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA059366
Pays : United States
Organisme : NINDS NIH HHS
ID : F31 NS101771
Pays : United States
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