Lineage-associated connexin 43 expression in bisphosphonate-exposed rat bones.

Animals Bisphosphonate-Associated Osteonecrosis of the Jaw Bone Density Conservation Agents / adverse effects Connexin 43 Diphosphonates Jaw Rats Tibia
Bisphosphonate Jawbone Medication-related osteonecrosis of the jaw (MRONJ)

Journal

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
ISSN: 1878-4119
Titre abrégé: J Craniomaxillofac Surg
Pays: Scotland
ID NLM: 8704309

Informations de publication

Date de publication:
Aug 2021
Historique:
received: 14 02 2020
revised: 19 11 2020
accepted: 14 02 2021
pubmed: 2 3 2021
medline: 10 8 2021
entrez: 1 3 2021
Statut: ppublish

Résumé

Expression of signaling proteins in bone cells depends on their embryological mesoderm-derived (e.g. tibia) or cranial neural crest (CNC)-derived (e.g. jaw) origin. Connexin 43 (Cx43) is a gap junction protein that plays an essential role in the mode of action of bisphosphonates (BP). This study aimed to investigate Cx43 expression and the influence of BP application on mesoderm- and CNC-derived bone. Using a rat model, molar extraction and tibia osteotomy with (Group 4) or without (Group 3) previous BP application was performed. Untreated (Group 1) and animals selectively treated with BPs (Group 2) served as controls. Cx43 expression was immunohistochemically determined 12 and 16 weeks postoperatively via a labeling index. Cx43 expression in CNC-derived bone was significantly higher compared with mesodermal bone. BP application decreased Cx43 expression; however, detected expression levels were still higher in jawbone (Group 2 tibia vs jaw: 5.83 ± 5.06 vs 23.52 ± 6.42; p = 0.007). During bone healing after surgical intervention (Group 3) there were no expression differences between tibia and jawbone. BP treatment prior to surgery resulted in significantly lower Cx43 expression in CNC-derived compared with tibia bone (Group 4 tibia vs jaw: 56.84 ± 15.57 vs 16.40 ± 5.66; p < 0.01). Increased Cx43 expression in jaw compared with tibia bone is in line with their embryological origins. A significant Cx43 suppression in jawbone after BP application and surgery might contribute to the selectively altered osseous turnover and development of MRONJ in CNC-derived bone.

Identifiants

DOI: 10.1016/j.jcms.2021.02.010 PMID: 33642117
pubmed: 33642117
pii: S1010-5182(21)00064-0
doi: 10.1016/j.jcms.2021.02.010
pii:
doi:

Substances chimiques

Bone Density Conservation Agents 0
Connexin 43 0
Diphosphonates 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

738-747

Informations de copyright

Copyright © 2021 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors of this manuscript have no conflicts of interest to disclose.

Auteurs

Raimund H M Preidl (RHM)

Resident, Department of Oral and Maxillofacial Surgery, University of Erlangen-Nuremberg, Glückstraße 11, 91056, Erlangen, Germany. Electronic address: raimund.preidl@uk-erlangen.de.

Kerstin Amann (K)

Head of Nephropathology, University of Erlangen-Nuremberg, Glückstraße 11, 91056, Erlangen, Germany.

Manuel Weber (M)

Resident, Department of Oral and Maxillofacial Surgery, University of Erlangen-Nuremberg, Glückstraße 11, 91056, Erlangen, Germany.

Martin Schiller (M)

Doctoral Students, Department of Oral and Maxillofacial Surgery, University of Erlangen-Nuremberg, Glückstraße 11, 91056, Erlangen, Germany.

Manuela Ringler (M)

Doctoral Students, Department of Oral and Maxillofacial Surgery, University of Erlangen-Nuremberg, Glückstraße 11, 91056, Erlangen, Germany.

Jutta Ries (J)

Department of Oral and Maxillofacial Surgery, University of Erlangen-Nuremberg, Glückstraße 11, 91056, Erlangen, Germany.

Friedrich W Neukam (FW)

Former Head of Department of Oral and Maxillofacial Surgery, University of Erlangen-Nuremberg, Glückstraße 11, 91056, Erlangen, Germany.

Marco Kesting (M)

Head of Department of Oral and Maxillofacial Surgery, University of Erlangen-Nuremberg, Glückstraße 11, 91056, Erlangen, Germany.

Carol-Immanuel Geppert (CI)

Specialist in Pathology, University of Erlangen-Nuremberg, Glückstraße 11, 91056, Erlangen, Germany.

Falk Wehrhan (F)

Specialist in Oral and Maxillofacial Surgery, Department of Oral and Maxillofacial Surgery, University of Erlangen-Nuremberg, Glückstraße 11, 91056, Erlangen, Germany.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Lineage-associated connexin 43 expression in...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Nécrose › Ostéonécrose › Ostéonécrose de la mâchoire associée aux biphosphonates › Lineage-associated connexin 43 expression in...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents de maintien de la densité osseuse › Lineage-associated connexin 43 expression in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Connexines › Connexine 43 › Lineage-associated connexin 43 expression in...
questionsmedicales.fr › Composés chimiques organiques › Composés organiques du phosphore › Phosphonates › Diphosphonates › Lineage-associated connexin 43 expression in...
questionsmedicales.fr › Système stomatognathique › Mâchoire › Lineage-associated connexin 43 expression in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Lineage-associated connexin 43 expression in...
questionsmedicales.fr › Appareil locomoteur › Squelette › Os du membre inférieur › Os de la jambe › Tibia › Lineage-associated connexin 43 expression in...