Up-regulation of miR-34b/c by JNK and FOXO3 protects from liver fibrosis.
FOXO3
JNK
liver fibrosis
miR-34b/c
α1 antitrypsin deficiency
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
09 03 2021
09 03 2021
Historique:
entrez:
2
3
2021
pubmed:
3
3
2021
medline:
17
8
2021
Statut:
ppublish
Résumé
α1-Antitrypsin (AAT) deficiency is a common genetic disease presenting with lung and liver diseases. AAT deficiency results from pathogenic variants in the
Identifiants
pubmed: 33649241
pii: 2025242118
doi: 10.1073/pnas.2025242118
pmc: PMC7958360
pii:
doi:
Substances chimiques
Forkhead Box Protein O3
0
FoxO3 protein, mouse
0
MIRN34b microRNA, mouse
0
MIRN34c microRNA, mouse
0
MicroRNAs
0
Serpina1a protein, mouse
0
alpha 1-Antitrypsin
0
MAP Kinase Kinase 4
EC 2.7.12.2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001453
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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