Genome editing reveals fitness effects of a gene for sexual dichromatism in Sulawesian fishes.
Animal Fins
/ anatomy & histology
Animals
Female
Gene Editing
Gene Expression Regulation
Genetic Association Studies
Genetic Fitness
Indonesia
Macrophage Colony-Stimulating Factor
/ genetics
Male
Mutation
/ genetics
Oryzias
/ genetics
Phylogeny
Pigmentation
/ genetics
Predatory Behavior
Quantitative Trait Loci
/ genetics
Sex Characteristics
Sexual Behavior, Animal
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
01 03 2021
01 03 2021
Historique:
received:
18
08
2020
accepted:
02
02
2021
entrez:
2
3
2021
pubmed:
3
3
2021
medline:
10
3
2021
Statut:
epublish
Résumé
Sexual selection drives rapid phenotypic diversification of mating traits. However, we know little about the causative genes underlying divergence in sexually selected traits. Here, we investigate the genetic basis of male mating trait diversification in the medaka fishes (genus Oryzias) from Sulawesi, Indonesia. Using linkage mapping, transcriptome analysis, and genome editing, we identify csf1 as a causative gene for red pectoral fins that are unique to male Oryzias woworae. A cis-regulatory mutation enables androgen-induced expression of csf1 in male fins. csf1-knockout males have reduced red coloration and require longer for mating, suggesting that coloration can contribute to male reproductive success. Contrary to expectations, non-red males are more attractive to a predatory fish than are red males. Our results demonstrate that integrating genomics with genome editing enables us to identify causative genes underlying sexually selected traits and provides a new avenue for testing theories of sexual selection.
Identifiants
pubmed: 33649298
doi: 10.1038/s41467-021-21697-0
pii: 10.1038/s41467-021-21697-0
pmc: PMC7921647
doi:
Substances chimiques
Macrophage Colony-Stimulating Factor
81627-83-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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