Positive fluid balance is associated with death and severity of brain injury in neonates with hypoxic-ischemic encephalopathy.
Journal
Journal of perinatology : official journal of the California Perinatal Association
ISSN: 1476-5543
Titre abrégé: J Perinatol
Pays: United States
ID NLM: 8501884
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
16
06
2020
accepted:
03
02
2021
revised:
15
01
2021
pubmed:
3
3
2021
medline:
9
10
2021
entrez:
2
3
2021
Statut:
ppublish
Résumé
To investigate the association between fluid balance during therapeutic hypothermia (TH) and severity of brain injury on magnetic resonance imaging (MRI) in neonates with hypoxic-ischemic encephalopathy (HIE). This is a secondary analysis of data from a prospective observational study in neonates with HIE. Daily net positive fluid balance during TH was investigated for association with the adverse primary outcome of death or moderate-to-severe brain injury on MRI using multivariable logistic regression. Of the 150 neonates included, 50 suffered adverse outcome and had significantly higher net positive fluid balance (53 vs. 19 ml/kg/day, p < 0.01) during first 24 hours of TH. Neonates with a net positive fluid balance (>25 ml/kg/day) at 24 hours of TH had 3.4 (95% CI 1.3-9) times higher odds of adverse outcome. Positive fluid balance during TH in neonates with HIE is independently associated with death or moderate-to-severe brain injury on MRI.
Identifiants
pubmed: 33649446
doi: 10.1038/s41372-021-00988-w
pii: 10.1038/s41372-021-00988-w
pmc: PMC10363283
mid: NIHMS1674773
doi:
Types de publication
Journal Article
Observational Study
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1331-1338Subventions
Organisme : NICHD NIH HHS
ID : U54 HD090257
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000075
Pays : United States
Organisme : NCRR NIH HHS
ID : KL2 RR031987
Pays : United States
Commentaires et corrections
Type : CommentIn
Références
Shankaran S, Laptook AR, Ehrenkranz RA, Tyson JE, McDonald SA, Donovan EF, et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N. Engl J Med. 2005;353:1574–84.
pubmed: 16221780
doi: 10.1056/NEJMcps050929
Jacobs SE, Morley CJ, Inder TE, Stewart MJ, Smith KR, McNamara PJ, et al. Whole-body hypothermia for term and near-term newborns with hypoxic-ischemic encephalopathy: a randomized controlled trial. Arch Pediatr Adolesc Med. 2011;165:692–700.
pubmed: 21464374
doi: 10.1001/archpediatrics.2011.43
Jacobs SE, Berg M, Hunt R, Tarnow-Mordi WO, Inder TE, Davis PG Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst Rev. 2013; (1): CD003311.
Natarajan G, Pappas A, Shankaran S. Outcomes in childhood following therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy (HIE). Semin Perinatol. 2016;40:549–55.
pubmed: 27863707
pmcid: 5370563
doi: 10.1053/j.semperi.2016.09.007
Shankaran S, Natarajan G, Chalak L, Pappas A, McDonald SA, Laptook AR. Hypothermia for neonatal hypoxic-ischemic encephalopathy: NICHD neonatal research network contribution to the field. Semin Perinatol. 2016;40:385–90.
pubmed: 27345952
pmcid: 5065734
doi: 10.1053/j.semperi.2016.05.009
Azzopardi DV, Strohm B, Edwards AD, Dyet L, Halliday HL, Juszczak E, et al. Moderate hypothermia to treat perinatal asphyxial encephalopathy. N Engl J Med. 2009;361:1349–58.
pubmed: 19797281
doi: 10.1056/NEJMoa0900854
Gluckman PD, Wyatt JS, Azzopardi D, Ballard R, Edwards AD, Ferriero DM, et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial. Lancet 2005;365:663–70.
pubmed: 15721471
doi: 10.1016/S0140-6736(05)17946-X
Azzopardi D. Clinical management of the baby with hypoxic ischaemic encephalopathy. Early Hum Dev. 2010;86:345–50.
pubmed: 20605382
doi: 10.1016/j.earlhumdev.2010.05.008
Martinello K, Hart AR, Yap S, Mitra S, Robertson NJ. Management and investigation of neonatal encephalopathy: 2017. update Arch Dis Child Fetal Neonatal Ed. 2017;102:F346–58.
pubmed: 28389438
doi: 10.1136/archdischild-2015-309639
Stola A, Perlman J. Post-resuscitation strategies to avoid ongoing injury following intrapartum hypoxia-ischemia. Semin Fetal Neonatal Med. 2008;13:424–31.
pubmed: 18501692
doi: 10.1016/j.siny.2008.04.011
Alobaidi R, Morgan C, Basu RK, Stenson E, Featherstone R, Majumdar SR, et al. Association between fluid balance and outcomes in critically ill children: a systematic review and meta-analysis. JAMA Pediatr. 2018;172:257–68.
pubmed: 29356810
pmcid: 5885847
doi: 10.1001/jamapediatrics.2017.4540
Bhaskar P, Dhar AV, Thompson M, Quigley R, Modem V. Early fluid accumulation in children with shock and ICU mortality: a matched case-control study. Intensive Care Med. 2015;41:1445–53.
pubmed: 26077052
doi: 10.1007/s00134-015-3851-9
Li Y, Wang J, Bai Z, Chen J, Wang X, Pan J, et al. Early fluid overload is associated with acute kidney injury and PICU mortality in critically ill children. Eur J Pediatr. 2016;175:39–48.
pubmed: 26206387
doi: 10.1007/s00431-015-2592-7
Silva JM, de Oliveira AM, Nogueira FA, Vianna PM, Pereira Filho MC, Dias LF, et al. The effect of excess fluid balance on the mortality rate of surgical patients: a multicenter prospective study. Crit Care. 2013;17:R288.
pubmed: 24326085
pmcid: 4057181
doi: 10.1186/cc13151
Zhao Z, Wang D, Jia Y, Tian Y, Wang Y, Wei Y, et al. Analysis of the association of fluid balance and short-term outcome in traumatic brain injury. J Neurol Sci. 2016;364:12–18.
pubmed: 27084207
doi: 10.1016/j.jns.2016.03.007
Selewski DT, Akcan-Arikan A, Bonachea EM, Gist KM, Goldstein SL, Hanna M, et al. The impact of fluid balance on outcomes in critically ill near-term/term neonates: a report from the AWAKEN study group. Pediatr Res. 2019;85:79–85.
pubmed: 30237572
doi: 10.1038/s41390-018-0183-9
Selewski DT, Cornell TT, Lombel RM, Blatt NB, Han YY, Mottes T, et al. Weight-based determination of fluid overload status and mortality in pediatric intensive care unit patients requiring continuous renal replacement therapy. Intensive Care Med. 2011;37:1166–73.
pubmed: 21533569
pmcid: 3315181
doi: 10.1007/s00134-011-2231-3
Barkovich AJ, Hajnal BL, Vigneron D, Sola A, Partridge JC, Allen F, et al. Prediction of neuromotor outcome in perinatal asphyxia: evaluation of MR scoring systems. AJNR Am J Neuroradiol. 1998;19:143–9.
pubmed: 9432172
Cheong JL, Coleman L, Hunt RW, Lee KJ, Doyle LW, Inder TE, et al. Prognostic utility of magnetic resonance imaging in neonatal hypoxic-ischemic encephalopathy: substudy of a randomized trial. Arch Pediatr Adolesc Med. 2012;166:634–40.
pubmed: 22751877
doi: 10.1001/archpediatrics.2012.284
Sarnat HB, Sarnat MS. Neonatal encephalopathy following fetal distress. A clinical and electroencephalographic study. Arch Neurol. 1976;33:696–705.
pubmed: 987769
doi: 10.1001/archneur.1976.00500100030012
Dell, KR. Fluid, electrolytes, and acid-base homeostasis. In: Martin RJ, Fanaroff AA, Walsh MC (eds). Fanaroff and martin’s neonatal-perinatal medicine, 9th edition: St. Louis, Missouri: Elsevier; 2011. p. 676.
Ultman JS. Computational model for insensible water loss from the newborn. Pediatrics 1987;79:760–65.
pubmed: 3575035
doi: 10.1542/peds.79.5.760
Kelleher MM, O’Carroll M, Gallagher A, Murray DM, Dunn Galvin A, Irvine AD, et al. Newborn transepidermal water loss values: a reference dataset. Pediatr Dermatol. 2013;30:712–16.
pubmed: 23458265
doi: 10.1111/pde.12106
Lindower JB. Water balance in the fetus and neonate. Semin Fetal Neonatal Med. 2017;22:71–75.
pubmed: 28153467
doi: 10.1016/j.siny.2017.01.002
Li AM, Chau V, Poskitt KJ, Sargent MA, Lupton BA, Hill A, et al. White matter injury in term newborns with neonatal encephalopathy. Pediatr Res. 2009;65:85–89.
pubmed: 18787422
doi: 10.1203/PDR.0b013e31818912d2
Selewski DT, Charlton JR, Jetton JG, Guillet R, Mhanna MJ, Askenazi DJ, et al. Neonatal acute kidney injury. Pediatrics 2015;136:e463–73.
pubmed: 26169430
doi: 10.1542/peds.2014-3819
Natarajan G, Mathur A, Zaniletti I, DiGeronimo R, Lee KS, Rao R, et al. Withdrawal of life-support in neonatal hypoxic-ischemic encephalopathy. Pediatr Neurol. 2019;91:20–26.
pubmed: 30559002
doi: 10.1016/j.pediatrneurol.2018.08.027
Anderson JM, Belton NR. Water and electrolyte abnormalities in the human brain after severe intrapartum asphyxia. J Neurol Neurosurg Psychiatry. 1974;37:514–20.
pubmed: 4836746
pmcid: 494695
doi: 10.1136/jnnp.37.5.514
Pryse-Davies J, Beard RW. A necropsy study of brain swelling in the newborn with special reference to cerebellar herniation. J Pathol. 1973;109:51–73.
pubmed: 4737063
doi: 10.1002/path.1711090107
Lupton BA, Hill A, Roland EH, Whitfield MF, Flodmark O. Brain swelling in the asphyxiated term newborn: pathogenesis and outcome. Pediatrics 1988;82:139–46.
pubmed: 3399286
doi: 10.1542/peds.82.2.139
Alaro D, Bashir A, Musoke R, Wanaiana L. Prevalence and outcomes of acute kidney injury in term neonates with perinatal asphyxia. Afr Health Sci. 2014;14:682–88.
pubmed: 25352889
pmcid: 4209658
doi: 10.4314/ahs.v14i3.26
Aggarwal A, Kumar P, Chowdhary G, Majumdar S, Narang A. Evaluation of renal functions in asphyxiated newborns. J Trop Pediatr. 2005;51:295–99.
pubmed: 16000344
doi: 10.1093/tropej/fmi017
Perlman JM, Tack ED. Renal injury in the asphyxiated newborn infant: relationship to neurologic outcome. J Pediatr. 1988;113:875–79.
pubmed: 3054034
doi: 10.1016/S0022-3476(88)80023-4
Cavallin F, Rubin G, Vidal E, Cainelli E, Bonadies L, Suppiej A, et al. Prognostic role of acute kidney injury on long-term outcome in infants with hypoxic-ischemic encephalopathy. Pediatr Nephrol. 2020;35:477–83.
pubmed: 31828471
doi: 10.1007/s00467-019-04406-4
Kaplan SL, Feigin RD. Inappropriate secretion of antidiuretic hormone complicating neonatal hypoxic-ischemic encephalopathy. J Pediatr. 1978;92:431–33.
pubmed: 632985
doi: 10.1016/S0022-3476(78)80437-5
Kecskes Z, Healy G, Jensen A Fluid restriction for term infants with hypoxic-ischaemic encephalopathy following perinatal asphyxia. Cochrane Database Syst Rev. 2005; (3):CD004337.
Kochanek PM, Tasker RC, Bell MJ, Adelson PD, Carney N, Vavilala MS, et al. Management of pediatric severe traumatic brain injury: 2019 consensus and guidelines-based algorithm for first and second tier therapies. Pediatr Crit Care Med. 2019;20:269–79.
pubmed: 30830015
doi: 10.1097/PCC.0000000000001737
Rossi S, Picetti E, Zoerle T, Carbonara M, Zanier ER, Stocchetti N. Fluid management in acute brain injury. Curr Neurol Neurosci Rep. 2018;18:74.
pubmed: 30206730
doi: 10.1007/s11910-018-0885-8
van der Jagt M. Fluid management of the neurological patient: a concise review. Crit Care. 2016;20:126.
pubmed: 27240859
pmcid: 4886412
doi: 10.1186/s13054-016-1309-2
Shenkin HA, Bezier HS, Bouzarth WF. Restricted fluid intake. rational management of the neurosurgical patient. J Neurosurg. 1976;45:432–6.
pubmed: 956879
doi: 10.3171/jns.1976.45.4.0432
Koskinen LO, Olivecrona M, Grände PO. Severe traumatic brain injury management and clinical outcome using the Lund concept. Neuroscience 2014;283:245–55.
pubmed: 24973658
doi: 10.1016/j.neuroscience.2014.06.039
Tanigasalam V, Plakkal N, Vishnu Bhat B, Chinnakali P. Does fluid restriction improve outcomes in infants with hypoxic ischemic encephalopathy? A pilot randomized controlled trial. J Perinatol. 2018;38:1512–7.
pubmed: 30206346
doi: 10.1038/s41372-018-0223-7
Montaldo P, Caredda E, Pugliese U, Zanfardino A, Delehaye C, Inserra E, et al. Continuous glucose monitoring profile during therapeutic hypothermia in encephalopathic infants with unfavorable outcome. Pediatr Res. 2020;88:218–24.
pubmed: 32120381
doi: 10.1038/s41390-020-0827-4
Basu SK, Kaiser JR, Guffey D, Minard CG, Guillet R, Gunn AJ, et al. Hypoglycaemia and hyperglycaemia are associated with unfavourable outcome in infants with hypoxic ischaemic encephalopathy: a post hoc analysis of the CoolCap Study. Arch Dis Child Fetal Neonatal Ed. 2016;101:F149–55.
pubmed: 26283669
doi: 10.1136/archdischild-2015-308733
Kasai M, Lear CA, Davidson JO, Beacom MJ, Drury PP, Maeda Y, et al. Early sinusoidal heart rate patterns and heart rate variability to assess hypoxia-ischaemia in near-term fetal sheep. J Physiol. 2019;597:5535–48.
pubmed: 31529698
doi: 10.1113/JP278523
Lear CA, Kasai M, Drury PP, Davidson JO, Miyagi E, Bennet L, et al. Plasma vasopressin levels are closely associated with fetal hypotension and neuronal injury after hypoxia-ischemia in near-term fetal sheep. Pediatr Res. 2020; e-pub ahead of print.
Summanen M, Bäck S, Voipio J, Kaila K. Surge of peripheral arginine vasopressin in a rat model of birth asphyxia. Front Cell Neurosci. 2018;12:2.
pubmed: 29403357
pmcid: 5780440
doi: 10.3389/fncel.2018.00002
Ayus JC, Achinger SG, Arieff A. Brain cell volume regulation in hyponatremia: role of sex, age, vasopressin, and hypoxia. Am J Physiol Ren Physiol. 2008;295:F619–24.
doi: 10.1152/ajprenal.00502.2007
Evers KS, Wellmann S. Arginine vasopressin and copeptin in perinatology. Front Pediatr. 2016;4:75.
pubmed: 27532032
pmcid: 4969663
doi: 10.3389/fped.2016.00075
Ayus JC, Armstrong D, Arieff AI. Hyponatremia with hypoxia: effects on brain adaptation, perfusion, and histology in rodents. Kidney Int. 2006;69:1319–25.
pubmed: 16614721
doi: 10.1038/sj.ki.5000187
Durkan AM, Alexander RT. Acute kidney injury post neonatal asphyxia. J Pediatr. 2011;158:e29–33.
pubmed: 21238703
doi: 10.1016/j.jpeds.2010.11.010
El-Gamasy MA, Alarabawy R. Relation of serum creatinine to sarnat scoring and brain computerized tomography of neonates with hypoxic ischemic encephalopathy. A single-center experience. J Pediatr Neurosci. 2018;13:437–42.
pubmed: 30937085
pmcid: 6413597
doi: 10.4103/JPN.JPN_64_18
Gupta C, Massaro AN, Ray PE. A new approach to define acute kidney injury in term newborns with hypoxic ischemic encephalopathy. Pediatr Nephrol. 2016;31:1167–78.
pubmed: 26857710
pmcid: 4882244
doi: 10.1007/s00467-016-3317-5
Sarkar S, Askenazi DJ, Jordan BK, Bhagat I, Bapuraj JR, Dechert RE, et al. Relationship between acute kidney injury and brain MRI findings in asphyxiated newborns after therapeutic hypothermia. Pediatr Res. 2014;75:431–5.
pubmed: 24296799
doi: 10.1038/pr.2013.230
Selewski DT, Jordan BK, Askenazi DJ, Dechert RE, Sarkar S. Acute kidney injury in asphyxiated newborns treated with therapeutic hypothermia. J Pediatr. 2013;162:725–9.
pubmed: 23149172
doi: 10.1016/j.jpeds.2012.10.002