Genomic epidemiology of COVID-19 in care homes in the east of England.
Aged, 80 and over
COVID-19
/ epidemiology
Disease Outbreaks
England
/ epidemiology
Female
Humans
Infectious Disease Transmission, Patient-to-Professional
Infectious Disease Transmission, Professional-to-Patient
Male
Nursing Homes
Polymorphism, Single Nucleotide
SARS-CoV-2
/ genetics
Sequence Analysis
Time Factors
COVID-19
SARS-CoV-2
epidemiology
genetics
genomics
global health
virus
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
02 03 2021
02 03 2021
Historique:
received:
04
11
2020
accepted:
25
02
2021
pubmed:
3
3
2021
medline:
7
4
2021
entrez:
2
3
2021
Statut:
epublish
Résumé
COVID-19 poses a major challenge to care homes, as SARS-CoV-2 is readily transmitted and causes disproportionately severe disease in older people. Here, 1167 residents from 337 care homes were identified from a dataset of 6600 COVID-19 cases from the East of England. Older age and being a care home resident were associated with increased mortality. SARS-CoV-2 genomes were available for 700 residents from 292 care homes. By integrating genomic and temporal data, 409 viral clusters within the 292 homes were identified, indicating two different patterns - outbreaks among care home residents and independent introductions with limited onward transmission. Approximately 70% of residents in the genomic analysis were admitted to hospital during the study, providing extensive opportunities for transmission between care homes and hospitals. Limiting viral transmission within care homes should be a key target for infection control to reduce COVID-19 mortality in this population.
Identifiants
pubmed: 33650490
doi: 10.7554/eLife.64618
pii: 64618
pmc: PMC7997667
doi:
pii:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Wellcome Trust
ID : COG-UK MC-PC-19027
Pays : United Kingdom
Organisme : Wellcome Trust
ID : Collabrative grant 204870/Z/16/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : COG-UK MC-PC-19027
Pays : United Kingdom
Organisme : Academy of Medical Sciences
ID : Clinician Scientist Fellowship
Pays : United Kingdom
Organisme : Academy of Medical Sciences
ID : Clinician Scientist Fellowship to MET
Pays : United Kingdom
Organisme : Wellcome Trust
ID : Senior Fellowship 097997/Z/11/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : COG-UK grant to SJP
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_19027
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N029399/1
Pays : United Kingdom
Informations de copyright
© 2021, Hamilton et al.
Déclaration de conflit d'intérêts
WH, GT, ES, DA, CH, BW, LM, MH, AJ, MC, SP, LC, SC, FK, AY, GH, TF, MP, IG, YC, CB, SG, RA, EH, NB, MB, MS, DJ, IJ, AA, JS, CL, GD, SP, DK, IG No competing interests declared, MT I have received grant support from the Academy of Medical Sciences, the Health Foundation, and the NIHR Biomedical Research Centre. I have also received book royalties from Oxford University Press and honoraria from the Wellcome Sanger Institute
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