Random Peptide Mixtures as Safe and Effective Antimicrobials against
Pseudomonas aeruginosa
Random peptide mixtures
Staphylococcus aureus
acute pneumonia
antibiotic resistance
bacteremia
Journal
ACS infectious diseases
ISSN: 2373-8227
Titre abrégé: ACS Infect Dis
Pays: United States
ID NLM: 101654580
Informations de publication
Date de publication:
12 03 2021
12 03 2021
Historique:
pubmed:
3
3
2021
medline:
24
6
2021
entrez:
2
3
2021
Statut:
ppublish
Résumé
Antibiotic resistance is a daunting challenge in modern medicine, and novel approaches that minimize the emergence of resistant pathogens are desperately needed. Antimicrobial peptides are newer therapeutics that attempt to do this; however, they fall short because of low to moderate antimicrobial activity, low protease stability, susceptibility to resistance development, and high cost of production. The recently developed random peptide mixtures (RPMs) are promising alternatives. RPMs are synthesized by incorporating a defined proportion of two amino acids at each coupling step rather than just one, making them highly variable but still defined in their overall composition, chain length, and stereochemistry. Because RPMs have extreme diversity, it is unlikely that bacteria would be capable of rapidly evolving resistance. However, their efficacy against pathogens in animal models of human infectious diseases remained uncharacterized. Here, we demonstrated that RPMs have strong safety and pharmacokinetic profiles. RPMs rapidly killed both
Identifiants
pubmed: 33650856
doi: 10.1021/acsinfecdis.0c00871
pmc: PMC8880176
mid: NIHMS1780009
doi:
Substances chimiques
Anti-Infective Agents
0
Peptides
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
672-680Subventions
Organisme : NIAID NIH HHS
ID : R01 AI080710
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL090699
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL142626
Pays : United States
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