Association of obesity with illness severity in hospitalized patients with COVID-19: A retrospective cohort study.
Adult
Age Factors
Aged
Aged, 80 and over
Body Mass Index
COVID-19
/ epidemiology
Comorbidity
Female
Hospital Mortality
Hospitalization
Humans
Intensive Care Units
Intubation
Logistic Models
Male
Middle Aged
Obesity
/ epidemiology
Odds Ratio
Patient Readmission
Retrospective Studies
Risk Factors
SARS-CoV-2
Severity of Illness Index
Sex Factors
COVID-19
Coronavirus
Hospitalization
ICU
Mortality
Obesity
Journal
Obesity research & clinical practice
ISSN: 1871-403X
Titre abrégé: Obes Res Clin Pract
Pays: Netherlands
ID NLM: 101303911
Informations de publication
Date de publication:
Historique:
received:
05
11
2020
revised:
14
02
2021
accepted:
19
02
2021
pubmed:
4
3
2021
medline:
30
3
2021
entrez:
3
3
2021
Statut:
ppublish
Résumé
Although recent studies have shown an association between obesity and adverse coronavirus disease 2019 (COVID-19) patient outcomes, there is a paucity in large studies focusing on hospitalized patients. We aimed to analyze outcomes associated with obesity in a large cohort of hospitalized COVID-19 patients. We performed a retrospective study at a tertiary care health system of adult patients with COVID-19 who were admitted between March 1 and April 30, 2020. Patients were stratified by body mass index (BMI) into obese (BMI ≥ 30 kg/m 2) and non-obese (BMI < 30 kg/m 2) cohorts. Primary outcomes were mortality, intensive care unit (ICU) admission, intubation, and 30-day readmission. A total of 1983 patients were included of whom 1031 (51.9%) had obesity and 952 (48.9%) did not have obesity. Patients with obesity were younger (P < 0.001), more likely to be female (P < 0.001) and African American (P < 0.001) compared to patients without obesity. Multivariable logistic models adjusting for differences in age, sex, race, medical comorbidities, and treatment modalities revealed no difference in 60-day mortality and 30-day readmission between obese and non-obese groups. In these models, patients with obesity had increased odds of ICU admission (adjusted OR, 1.37; 95% CI, 1.07-1.76; P = 0.012) and intubation (adjusted OR, 1.37; 95% CI, 1.04-1.80; P = 0.026). Obesity in patients with COVID-19 is independently associated with increased risk for ICU admission and intubation. Recognizing that obesity impacts morbidity in this manner is crucial for appropriate management of COVID-19 patients.
Sections du résumé
BACKGROUND
Although recent studies have shown an association between obesity and adverse coronavirus disease 2019 (COVID-19) patient outcomes, there is a paucity in large studies focusing on hospitalized patients. We aimed to analyze outcomes associated with obesity in a large cohort of hospitalized COVID-19 patients.
METHODS
We performed a retrospective study at a tertiary care health system of adult patients with COVID-19 who were admitted between March 1 and April 30, 2020. Patients were stratified by body mass index (BMI) into obese (BMI ≥ 30 kg/m 2) and non-obese (BMI < 30 kg/m 2) cohorts. Primary outcomes were mortality, intensive care unit (ICU) admission, intubation, and 30-day readmission.
RESULTS
A total of 1983 patients were included of whom 1031 (51.9%) had obesity and 952 (48.9%) did not have obesity. Patients with obesity were younger (P < 0.001), more likely to be female (P < 0.001) and African American (P < 0.001) compared to patients without obesity. Multivariable logistic models adjusting for differences in age, sex, race, medical comorbidities, and treatment modalities revealed no difference in 60-day mortality and 30-day readmission between obese and non-obese groups. In these models, patients with obesity had increased odds of ICU admission (adjusted OR, 1.37; 95% CI, 1.07-1.76; P = 0.012) and intubation (adjusted OR, 1.37; 95% CI, 1.04-1.80; P = 0.026).
CONCLUSIONS
Obesity in patients with COVID-19 is independently associated with increased risk for ICU admission and intubation. Recognizing that obesity impacts morbidity in this manner is crucial for appropriate management of COVID-19 patients.
Identifiants
pubmed: 33653666
pii: S1871-403X(21)00032-6
doi: 10.1016/j.orcp.2021.02.006
pmc: PMC7904471
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
172-176Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2021 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.