Investigating the association between cancer and the risk of dementia: Results from the Memento cohort.
Alzheimer's disease
cancer
dementia
epidemiology
illness-death model
selection bias
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
revised:
07
01
2021
received:
02
11
2020
accepted:
18
01
2021
pubmed:
4
3
2021
medline:
31
12
2021
entrez:
3
3
2021
Statut:
ppublish
Résumé
Studies on the association of cancer and risk of dementia are inconclusive due to result heterogeneity and concerns of survivor bias and unmeasured confounding. This study uses data from the Memento cohort, a French multicenter cohort following persons with either mild or isolated cognitive complaints for a median of 5 years. Illness-death models (IDMs) were used to estimate transition-specific hazard ratios (HRs) and 95% confidence intervals (CIs) for incident cancer in relation to dementia from time since study entry. The analytical sample (N = 2258) excluded 65 individuals without follow-up information. At the end of follow-up, 286 individuals were diagnosed with dementia, 166 with incident cancer, and 95 died. Incident cancer was associated with a reduced risk of dementia (HR = 0.58, 95% CI = 0.35-0.97), with a corresponding E-value of 2.84 (lower CI = 1.21). This study supports a protective relationship between incident cancer and dementia, encouraging further investigations to understand potential underlying mechanisms.
Identifiants
pubmed: 33656287
doi: 10.1002/alz.12308
pmc: PMC8518910
doi:
Types de publication
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1415-1421Subventions
Organisme : Medical Research Council
ID : MR/L023784/2
Pays : United Kingdom
Informations de copyright
© 2021 The Authors. Alzheimer's & Dementia published by Wiley Periodicals, LLC on behalf of Alzheimer's Association.
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