Endothelin-1 drives invadopodia and interaction with mesothelial cells through ILK.
Actin Depolymerizing Factors
/ genetics
Animals
Antineoplastic Agents
/ pharmacology
Cell Adhesion
/ drug effects
Cell Line, Tumor
Cell Movement
/ drug effects
Coculture Techniques
Databases, Genetic
Endothelin A Receptor Antagonists
/ pharmacology
Endothelin-1
/ pharmacology
Epithelial Cells
/ enzymology
Female
Gene Expression Regulation, Neoplastic
Humans
Mice, Inbred NOD
Mice, SCID
Neoplasm Invasiveness
Ovarian Neoplasms
/ drug therapy
Peritoneum
/ enzymology
Phenylpropionates
/ pharmacology
Phosphorylation
Podosomes
/ drug effects
Protein Serine-Threonine Kinases
/ genetics
Pyridazines
/ pharmacology
Receptor, Endothelin A
/ drug effects
Rho Guanine Nucleotide Exchange Factors
/ genetics
Signal Transduction
Tumor Microenvironment
Xenograft Model Antitumor Assays
beta-Arrestin 1
/ genetics
p21-Activated Kinases
/ genetics
rac GTP-Binding Proteins
/ genetics
ILK
PAK1
Rac3
endothelin A receptor
endothelin-1
invadopodia
mesothelial cells
serous ovarian cancer
β-arr1
βPIX
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
02 03 2021
02 03 2021
Historique:
received:
21
04
2020
revised:
02
01
2021
accepted:
05
02
2021
entrez:
3
3
2021
pubmed:
4
3
2021
medline:
27
1
2022
Statut:
ppublish
Résumé
Cancer cells use actin-based membrane protrusions, invadopodia, to degrade stroma and invade. In serous ovarian cancer (SOC), the endothelin A receptor (ET
Identifiants
pubmed: 33657382
pii: S2211-1247(21)00114-5
doi: 10.1016/j.celrep.2021.108800
pii:
doi:
Substances chimiques
ARHGEF7 protein, human
0
ARRB1 protein, human
0
Actin Depolymerizing Factors
0
Antineoplastic Agents
0
EDNRA protein, human
0
Endothelin A Receptor Antagonists
0
Endothelin-1
0
Phenylpropionates
0
Pyridazines
0
RAC3 protein, human
0
Receptor, Endothelin A
0
Rho Guanine Nucleotide Exchange Factors
0
beta-Arrestin 1
0
integrin-linked kinase
EC 2.7.1.-
PAK1 protein, human
EC 2.7.11.1
Protein Serine-Threonine Kinases
EC 2.7.11.1
p21-Activated Kinases
EC 2.7.11.1
rac GTP-Binding Proteins
EC 3.6.5.2
ambrisentan
HW6NV07QEC
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
108800Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.