Gender differences in the prevalence of frailty in heart failure: A systematic review and meta-analysis.
Aging
Frailty
Gender
Heart failure
Meta-analysis
Systematic review
Women
Journal
International journal of cardiology
ISSN: 1874-1754
Titre abrégé: Int J Cardiol
Pays: Netherlands
ID NLM: 8200291
Informations de publication
Date de publication:
15 06 2021
15 06 2021
Historique:
received:
08
12
2020
revised:
29
01
2021
accepted:
22
02
2021
pubmed:
4
3
2021
medline:
1
6
2021
entrez:
3
3
2021
Statut:
ppublish
Résumé
This study quantitatively synthesized literature to identify gender differences in the prevalence of frailty in heart failure (HF). The intersection of frailty and HF continues to garner interest. Almost half of patients with HF are frail; however, gender differences in frailty in HF are poorly understood. We performed a literature search to identify studies that reported prevalence of frailty by gender in HF. Random-effects meta-analysis was used to quantify the relative and absolute risk of frailty in women compared with men with HF, overall, and by Physical and Multidimensional Frailty measures. Meta-regression was performed to examine the influence of study age and functional class on relative risk in HF. Twenty-nine studies involving 8854 adults with HF were included. Overall in HF, women had a 26% higher relative risk of being frail compared with men (95% CI = 1.14-1.38, z = 4.69, p < 0.001, I In HF, frailty affects women significantly more than men. Future work should focus on elucidating potential causes of gender differences in frailty in HF.
Sections du résumé
OBJECTIVES
This study quantitatively synthesized literature to identify gender differences in the prevalence of frailty in heart failure (HF).
BACKGROUND
The intersection of frailty and HF continues to garner interest. Almost half of patients with HF are frail; however, gender differences in frailty in HF are poorly understood.
METHODS
We performed a literature search to identify studies that reported prevalence of frailty by gender in HF. Random-effects meta-analysis was used to quantify the relative and absolute risk of frailty in women compared with men with HF, overall, and by Physical and Multidimensional Frailty measures. Meta-regression was performed to examine the influence of study age and functional class on relative risk in HF.
RESULTS
Twenty-nine studies involving 8854 adults with HF were included. Overall in HF, women had a 26% higher relative risk of being frail compared with men (95% CI = 1.14-1.38, z = 4.69, p < 0.001, I
CONCLUSIONS
In HF, frailty affects women significantly more than men. Future work should focus on elucidating potential causes of gender differences in frailty in HF.
Identifiants
pubmed: 33657397
pii: S0167-5273(21)00371-5
doi: 10.1016/j.ijcard.2021.02.062
pmc: PMC8107129
mid: NIHMS1678636
pii:
doi:
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
133-140Subventions
Organisme : NICHD NIH HHS
ID : K12 HD043488
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest None.
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