A Burned-Out CD8
Journal
Cancer discovery
ISSN: 2159-8290
Titre abrégé: Cancer Discov
Pays: United States
ID NLM: 101561693
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
03
07
2020
revised:
06
01
2021
accepted:
26
02
2021
pubmed:
5
3
2021
medline:
1
3
2022
entrez:
4
3
2021
Statut:
ppublish
Résumé
Specific mechanisms by which tumor-infiltrating lymphocytes (TIL) become dysfunctional remain poorly understood. Here, we employed a two-pronged approach using single-cell mass cytometry and tissue imaging technologies to dissect TILs from 25 patients with resectable and 35 patients with advanced non-small cell lung cancer (NSCLC). We identified a burned-out CD8
Identifiants
pubmed: 33658301
pii: 2159-8290.CD-20-0962
doi: 10.1158/2159-8290.CD-20-0962
pmc: PMC9421941
mid: NIHMS1682022
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1700-1715Subventions
Organisme : NCATS NIH HHS
ID : KL2 TR001862
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA196530
Pays : United States
Organisme : NCI NIH HHS
ID : R03 CA219603
Pays : United States
Organisme : NCI NIH HHS
ID : R37 CA245154
Pays : United States
Informations de copyright
©2021 American Association for Cancer Research.
Références
Cancer Cell. 2019 Dec 9;36(6):613-629.e7
pubmed: 31761658
Nat Med. 2018 Jul;24(7):986-993
pubmed: 29942092
Nat Biotechnol. 2013 Jun;31(6):545-52
pubmed: 23685480
Nat Commun. 2017 Sep 27;8(1):707
pubmed: 28955032
Cell. 2017 May 4;169(4):750-765.e17
pubmed: 28475900
Nature. 2019 Dec;576(7787):465-470
pubmed: 31827286
Nat Rev Immunol. 2015 Aug;15(8):486-99
pubmed: 26205583
Nat Commun. 2017 Nov 10;8(1):1404
pubmed: 29123081
Immunity. 2019 Feb 19;50(2):477-492.e8
pubmed: 30737146
Nature. 2018 May;557(7706):575-579
pubmed: 29769722
Nature. 2020 Feb;578(7796):615-620
pubmed: 31959985
Nat Commun. 2017 Feb 01;8:14381
pubmed: 28146145
Nature. 2006 Feb 9;439(7077):682-7
pubmed: 16382236
J Immunother Cancer. 2019 Aug 7;7(1):209
pubmed: 31391096
Nat Immunol. 2011 Jun;12(6):492-9
pubmed: 21739672
Nature. 2019 May;569(7756):428-432
pubmed: 31043740
Nat Biotechnol. 2014 Apr;32(4):364-72
pubmed: 24633240
Clin Cancer Res. 2018 Apr 1;24(7):1562-1573
pubmed: 29203588
Nature. 1999 Oct 14;401(6754):708-12
pubmed: 10537110
Cell. 2018 Aug 23;174(5):1293-1308.e36
pubmed: 29961579
Sci Transl Med. 2012 Mar 28;4(127):127ra37
pubmed: 22461641
Annu Rev Anal Chem (Palo Alto Calif). 2019 Jun 12;12(1):411-430
pubmed: 30699035
Nat Methods. 2014 Apr;11(4):417-22
pubmed: 24584193
Genome Biol. 2014;15(12):550
pubmed: 25516281
Cell. 2019 Feb 7;176(4):775-789.e18
pubmed: 30595452
Cancer Res. 2015 Sep 1;75(17):3466-78
pubmed: 26113085
Br J Cancer. 2019 Nov;121(11):979-982
pubmed: 31666667
Immunity. 2019 Jan 15;50(1):195-211.e10
pubmed: 30635237
Cancer Immunol Res. 2016 Mar;4(3):194-203
pubmed: 26787823
Cell. 2017 May 4;169(4):736-749.e18
pubmed: 28475899
Immunity. 2019 Jan 15;50(1):181-194.e6
pubmed: 30635236
Nature. 2014 Nov 27;515(7528):568-71
pubmed: 25428505
Cell. 2018 Oct 4;175(2):313-326
pubmed: 30290139
Nat Biotechnol. 2015 Mar;33(3):290-5
pubmed: 25690850
Nat Commun. 2018 Aug 10;9(1):3196
pubmed: 30097571
Cytometry A. 2013 May;83(5):483-94
pubmed: 23512433
J Clin Invest. 2015 Sep;125(9):3384-91
pubmed: 26325035
Nat Med. 2002 Aug;8(8):793-800
pubmed: 12091876
Nat Med. 2018 Jul;24(7):994-1004
pubmed: 29892065
Cancer Immunol Res. 2018 Jan;6(1):14-24
pubmed: 29097422
Nature. 2016 Sep 15;537(7620):417-421
pubmed: 27501248
Nat Methods. 2015 Apr;12(4):357-60
pubmed: 25751142
Nat Med. 1999 Dec;5(12):1365-9
pubmed: 10581077
Cancer Discov. 2018 Feb;8(2):196-215
pubmed: 29101162
Cell. 2017 Jun 15;169(7):1342-1356.e16
pubmed: 28622514
Nat Med. 2016 Nov;22(11):1351-1357
pubmed: 27723723
Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):E2770-7
pubmed: 24979804
Cell. 2018 Dec 13;175(7):1972-1988.e16
pubmed: 30550791